当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > ATP-induced entry of calcium in thyroid FRTL-5 cells. Studies with phorbol myristate acetate and thapsigargin.

ATP-induced entry of calcium in thyroid FRTL-5 cells. Studies with phorbol myristate acetate and thapsigargin.

Abstract：

:Receptor-mediated Ca2+ entry was investigated in fura-2-loaded thyroid FRTL-5 cells. Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) attenuated the ATP-induced increase in intracellular free Ca2+ ([Ca2+]i). In PKC down-regulated cells, the ATP-induced increase in [Ca2+]i was increased compared with control cells. This enhanced increase in [Ca2+]i was apparently dependent on extracellular Ca2+, as no difference was observed between control cells and PKC down-regulated cells in Ca(2+)-free buffer. Addition of Ca2+ to cells stimulated with ATP in Ca(2+)-free buffer rapidly increased [Ca2+]i. The increase was blocked by PMA. However, PKC down-regulation had no effect on the [Ca2+]i response. Stimulating FRTL-5 cells with thapsigargin increased [Ca2+]i. Addition of ATP after thapsigargin had almost no effect on [Ca2+]i. In PKC down-regulated cells, addition of ATP after thapsigargin evoked a substantial increase in [Ca2+]i which was dependent on extracellular Ca2+. The results indicate that PKC has a modulatory effect on the ATP-induced entry of Ca2+ in FRTL-5 cells.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Törnquist K

doi

10.1016/0303-7207(93)90134-6

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

17-21

issue

1

eissn

0303-7207

issn

1872-8057

journal_volume

93

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Immunocytochemical localization of inhibin in rat and human reproductive tissues.

    abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90162-6

    authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

    更新日期：1987-12-01 00:00:00

  • Auto-regulation of estrogen receptor subtypes and gene expression profiling of 17beta-estradiol action in the neuroendocrine axis of male goldfish.

    abstract：:Auto-regulation of the three goldfish estrogen receptor (ER) subtypes was examined simultaneously in multiple tissues, in relation to mRNA levels of liver vitellogenin (VTG) and brain transcripts. Male goldfish were implanted with a silastic implant containing either no steroid or 17beta-estradiol (E2) (100 microg/g b...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.10.013

    authors： Marlatt VL,Martyniuk CJ,Zhang D,Xiong H,Watt J,Xia X,Moon T,Trudeau VL

    更新日期：2008-02-13 00:00:00

  • Role of metal ions in ligand-receptor interaction: insights from structural studies.

    abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.11.023

    authors： Ananthanarayanan VS,Kerman A

    更新日期：2006-02-26 00:00:00

  • Relevance of coexpression of somatostatin and dopamine D2 receptors in pituitary adenomas.

    abstract：:Dopamine and somatostatin are both involved in the negative control of normal pituitary cells. Dopamine subtype 2 receptor (D2DR) and somatostatin receptor (sst) agonists, mainly directed to sst2, are used in the treatment of pituitary adenomas. Nevertheless, a majority of corticotroph and gonadotroph adenomas and a t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2007.12.008

    authors： Saveanu A,Jaquet P,Brue T,Barlier A

    更新日期：2008-05-14 00:00:00

  • Patterns of LHbetacf among women in health and disease.

    abstract：:Urine based gonadotropin assays provide a practical means of analyzing hormone secretion patterns. While research protocols have revealed pulsatile patterns of gonadotropins such as LH in the blood, these assays are of limited clinical use since daily venipuncture sampling is not feasible outside of a research environ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.02.020

    authors： Birken S,McChesney R,Yershova O,Gaughan J,Pettersson K,Rechenberg G,Wu CH,Taliadouros G

    更新日期：2007-01-02 00:00:00

  • Hypospadias: interactions between environment and genetics.

    abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2011.01.006

    authors： Kalfa N,Philibert P,Baskin LS,Sultan C

    更新日期：2011-03-30 00:00:00

  • The steroidogenic effect of single-chain bovine LH analogs in cultured bovine follicular cells.

    abstract：:Single-chain gonadotropin analogs had been constructed for the purpose of structure-function studies and analog design. Incorporation of a spacer derived from the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit between the tethered subunit domains of the human gonadotropins is beneficial fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.03.011

    authors： Braw-Tal R,Pen S,Grinberg M,Nakav S,Ben-Menahem D

    更新日期：2006-06-27 00:00:00

  • Bisphenol A stimulates differentiation of rat stem Leydig cells in vivo and in vitro.

    abstract：:Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration mo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.03.003

    authors： Chen L,Zhao Y,Li L,Xie L,Chen X,Liu J,Li X,Jin L,Li X,Ge RS

    更新日期：2018-10-15 00:00:00

  • Stromal cells from the rat prostate secrete androgen-regulated factors which modulate Sertoli cell function.

    abstract：:Testicular peritubular cells produce paracrine mediators which modulate Sertoli cell function. The production of these mediators (P Mod-S) is controlled by androgens suggesting that mesenchymal-epithelial interactions play an important role in androgen action in the testis. We investigated whether mesenchymal cells fr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90124-x

    authors： Swinnen K,Cailleau J,Heyns W,Verhoeven G

    更新日期：1989-03-01 00:00:00

  • Administration of growth hormone modulates the gene expression of basic fibroblast growth factor in rat costal cartilage, both in vivo and in vitro.

    abstract：:We examined the effect of growth hormone on local growth factor mRNA expression in male Sprague-Dawley rats. Repetitive systemic administration of growth hormone (0.4 IU every 4 h) increased the expression of IGF-I mRNA up to 2.8-fold in costal cartilage tissue compared with controls. Basic FGF (bFGF) mRNA expression ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03591-t

    authors： Izumi T,Shida J,Jingushi S,Hotokebuchi T,Sugioka Y

    更新日期：1995-07-01 00:00:00

  • Marsupial models for understanding evolution of thyroid hormone distributor proteins.

    abstract：:Marsupials are a group of mammals that are under-exploited, in particular in developmental and evolutionary studies of biological systems. In this review, the roles that marsupials have played in elucidating the evolution of thyroid hormone distribution systems are summarised. Marsupials are born at very early develop...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.04.002

    authors： Richardson SJ

    更新日期：2008-10-10 00:00:00

  • An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells.

    abstract：:Individual variation in sensitivity to glucocorticoids (GCs) poses a dilemma to the clinician. Currently available assays to determine individual sensitivity to GCs either seem imprecise, or they are based on mitogen-activated lymphocytes, although mitogens themselves may affect cellular GC sensitivity. To avoid these...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.12.011

    authors： Vermeer H,Hendriks-Stegeman BI,van Suylekom D,Rijkers GT,van Buul-Offers SC,Jansen M

    更新日期：2004-04-15 00:00:00

  • Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors.

    abstract：:Recently, we have identified three distinct types of gonadotropin-releasing hormone receptor (GnRHR) in the bullfrog (designated bfGnRHR-1, bfGnRHR-2, and bfGnRHR-3). In the present study, we compared G protein coupling preference of mammalian and nonmammalian GnRHRs. In a transient expression system, stimulation of e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(03)00204-1

    authors： Oh DY,Wang L,Ahn RS,Park JY,Seong JY,Kwon HB

    更新日期：2003-07-31 00:00:00

  • Fibroblast growth factor-21, energy balance and obesity.

    abstract：:Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes. In addition to its effects improving insulin sensitivity, FGF21 causes weight loss by increasing energy ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2015.09.018

    authors： Giralt M,Gavaldà-Navarro A,Villarroya F

    更新日期：2015-12-15 00:00:00

  • Differential expression of vitelline membrane outer layer protein 1: hormonal regulation of expression in the oviduct and in ovarian carcinomas from laying hens.

    abstract：:Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. Although VMO1 is expressed in the o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.10.015

    authors： Lim W,Song G

    更新日期：2015-01-05 00:00:00

  • 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation.

    abstract：:Although well-established, the underlying mechanisms involved in obesity-related plasma adiponectin decline remain elusive. Oxidative stress is associated with obesity and insulin resistance and considered to contribute to the progression toward obesity-related metabolic disorders. In this study, we investigated the e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.10.027

    authors： Wang Z,Dou X,Gu D,Shen C,Yao T,Nguyen V,Braunschweig C,Song Z

    更新日期：2012-02-26 00:00:00

  • Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor.

    abstract：:Human breast cancer cells selected for multidrug resistance frequently overexpress ligands and receptors in the epidermal growth factor (EGF) receptor family. To determine whether this overexpression contributes to the drug resistant phenotype, EGF receptor transfected ZR75B human breast cancer cells were examined. Tw...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03535-f

    authors： Dickstein BM,Wosikowski K,Bates SE

    更新日期：1995-04-28 00:00:00

  • Evaluating the effects on steroidogenesis of estragole and trans-anethole in a feto-placental co-culture model.

    abstract：:In this study, we determined whether estragole and its isomer trans-anethole interfered with feto-placental steroidogenesis in a human co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. Estragole and trans-anethole are considered the biologically active compound...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2019.110583

    authors： Yancu D,Vaillancourt C,Sanderson JT

    更新日期：2019-12-01 00:00:00

  • Estradiol modulates TGF-β1 expression and its signaling pathway in thyroid stromal cells.

    abstract：:The higher prevalence of thyroid disease in women suggests that estrogen (E2) might be involved in the pathophysiology of thyroid dysfunction. To approach the question of the effect of stromal cells in the modulation of thyroid epithelial cells activity, we established and characterized a homogeneous stromal cell popu...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.02.001

    authors： Gantus MA,Alves LM,Stipursky J,Souza EC,Teodoro AJ,Alves TR,Carvalho DP,Martinez AM,Gomes FC,Nasciutti LE

    更新日期：2011-04-30 00:00:00

  • Directional secretion and transport of leptin and expression of leptin receptor isoforms in human placental BeWo cells.

    abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.05.003

    authors： Wyrwoll CS,Mark PJ,Waddell BJ

    更新日期：2005-09-28 00:00:00

  • Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells.

    abstract：:Corticotropin-releasing factor (CRF) receptor type 1 (CRF(1) receptor) mRNA levels are down-regulated by CRF via the cyclic AMP-protein kinase A (PKA) pathway. In this study, we focused on the involvement of both the mitogen-activated protein (MAP) kinase pathway and PKA in this regulation. Real-time PCR (RT-PCR) reve...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.09.010

    authors： Moriyama T,Kageyama K,Kasagi Y,Iwasaki Y,Nigawara T,Sakihara S,Suda T

    更新日期：2005-11-24 00:00:00

  • Proteasome inhibitor enhances growth hormone-binding protein release.

    abstract：:We used murine Ba/F3 cells transfected with human growth hormone receptor (hGHR) cDNA to investigate the regulatory mechanisms of human growth hormone-binding protein (hGH-BP) release. The extracellular domain of hGHRs were cleaved and released as hGH-BPs (a soluble form of hGHR). The hGH-BP release was enhanced by ph...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00583-4

    authors： Takagi K,Saito Y,Sawada J

    更新日期：2001-09-01 00:00:00

  • Cyclic AMP inhibits the synthesis and release of prolactin from human decidual cells.

    abstract：:Exposure of human decidual cells for 0.5 h to dibutyryl cAMP, isobutyl-methylxanthine (IBMX), cholera toxin or forskolin caused a dose-dependent inhibition of prolactin release with maximal inhibition by each agent of 50-60%. Dibutyryl cAMP (5 mM), IBMX (0.5 mM), and cholera toxin (10 micrograms/ml) also inhibited pro...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90081-5

    authors： Handwerger S,Harman I,Costello A,Markoff E

    更新日期：1987-03-01 00:00:00

  • cAMP signalling in the normal and tumorigenic pituitary gland.

    abstract：:cAMP signalling plays a key role in the normal physiology of the pituitary gland, regulating cellular growth and proliferation, hormone production and release. Deregulation of the cAMP signalling pathway has been reported to be a common occurrence in pituitary tumorigenesis. Several mechanisms have been implicated inc...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2014.05.004

    authors： Formosa R,Vassallo J

    更新日期：2014-07-05 00:00:00

  • Characterization of a corticotropin releasing hormone responsive region in the murine proopiomelanocortin gene.

    abstract：:The most potent, physiologic activator of proopiomelanocortin (POMC) gene transcription is corticotropin releasing hormone (CRH) and increased intracellular cAMP is critical for this effect. The 5'-flanking region of the murine POMC gene has several potential binding sites for regulatory proteins. To characterize the ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(93)90224-8

    authors： Bishop JF,Mouradian MM

    更新日期：1993-11-01 00:00:00

  • Calcium-dependent actions of gonadotropin-releasing hormone agonist and luteinizing hormone upon cyclic AMP and progesterone production in rat ovarian granulosa cells.

    abstract：:The Ca2+ dependency of the direct stimulatory effect of the gonadotropin-releasing hormone (GnRH) agonist analog [D-Ser(t-Bu)6]des-Gly10-GnRH-N-ethylamide (GnRHa) on progesterone production was investigated and compared to that of luteinizing hormone (LH) in rat granulosa cells from preovulatory follicles. Removal of ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90019-5

    authors： Eckstein N,Eshel A,Eli Y,Ayalon D,Naor Z

    更新日期：1986-09-01 00:00:00

  • A selective biotinylated probe for V1a vasopressin receptors.

    abstract：:We have designed and synthesized a biotinylated vasopressin antagonist which is a selective probe for studying the V1a subtype of vasopressin receptor. Initially we synthesized the novel vasopressin analogue d(CH2)5Tyr(Me)2LysNH2(9)AVP (ALVP). Biotinamidocaproate was subsequently coupled to the epsilon-amino group of ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(91)90066-2

    authors： Howl J,Kerr ID,Chan CH,Wheatley M

    更新日期：1991-05-01 00:00:00

  • Gonadotropins and inhibins along the development of a luteinized rat ovarian tumor.

    abstract：:Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-linked immunosorbent as...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(03)00085-6

    authors： Hockl P,Sorianello E,Chamson-Reig A,Ballerini G,Campo S,Groome N,Lux-Lantos V,Libertun C

    更新日期：2003-05-30 00:00:00

  • VIP induces the decidualization program and conditions the immunoregulation of the implantation process.

    abstract：:The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo impl...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2017.07.006

    authors： Grasso E,Gori S,Paparini D,Soczewski E,Fernández L,Gallino L,Salamone G,Martinez G,Irigoyen M,Ruhlmann C,Pérez Leirós C,Ramhorst R

    更新日期：2018-01-15 00:00:00

  • The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling.

    abstract：:Oxytocin (OT) plays an important role in the onset of human labour by stimulating uterine contractions and promoting prostaglandin/inflammatory cytokine synthesis in amnion via oxytocin receptor (OTR) coupling. The OTR-antagonist, Atosiban, is widely used as a tocolytic for the management of acute preterm labour. We f...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.11.012

    authors： Kim SH,MacIntyre DA,Hanyaloglu AC,Blanks AM,Thornton S,Bennett PR,Terzidou V

    更新日期：2016-01-15 00:00:00