当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling.

The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling.

Abstract：

:Oxytocin (OT) plays an important role in the onset of human labour by stimulating uterine contractions and promoting prostaglandin/inflammatory cytokine synthesis in amnion via oxytocin receptor (OTR) coupling. The OTR-antagonist, Atosiban, is widely used as a tocolytic for the management of acute preterm labour. We found that in primary human amniocytes, Atosiban (10 μM) signals via PTX-sensitive Gαi to activate transcription factor NF-κB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p < 0.05, ANOVA). Moreover, Atosiban treatment increased expression and excretion of the inflammatory cytokines, IL-6 and CCL5. We also showed that OT-simulated activation of NF-κB, ERK1/2, and p38 and subsequent prostaglandin and inflammatory cytokine synthesis is via Gαi-2 and Gαi-3 but not Gαq, and is not inhibited by Atosiban. Activation or exacerbation of inflammation is not a desirable effect of tocolytics. Therefore therapeutic modulation of the OT/OTR system for clinical management of term/preterm labour should consider the effects of differential G-protein coupling of the OTR and the role of OT or selective OTR agonists/antagonists in activating proinflammatory pathways.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Kim SH,MacIntyre DA,Hanyaloglu AC,Blanks AM,Thornton S,Bennett PR,Terzidou V

doi

10.1016/j.mce.2015.11.012

subject

Has Abstract

pub_date

2016-01-15 00:00:00

pages

11-23

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(15)30137-4

journal_volume

420

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiat

    abstract：:Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and r...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.10.014

    authors： Ichijo T,Chrousos GP,Kino T

    更新日期：2008-02-13 00:00:00

  • Interleukin 6 inhibits the differentiation of rat stem Leydig cells.

    abstract：:Inflammation causes male hypogonadism. Several inflammatory cytokines, including interleukin 6 (IL-6), are released into the blood and may suppress Leydig cell development. The objective of the present study was to investigate whether IL-6 affected the proliferation and differentiation of rat stem Leydig cells. Leydig...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2017.11.016

    authors： Wang Y,Chen L,Xie L,Li L,Li X,Li H,Liu J,Chen X,Mao B,Song T,Lian Q,Ge RS

    更新日期：2018-09-05 00:00:00

  • Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor γ in diabetic cardiomyopathy.

    abstract：:Diabetic cardiomyopathy is characterized by an abnormal oxidative metabolism, but the underlying mechanisms remain to be defined. To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression profiling study in hearts of diabetic db/db mice. Diabetic hearts ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.04.004

    authors： Lasheras J,Vilà M,Zamora M,Riu E,Pardo R,Poncelas M,Cases I,Ruiz-Meana M,Hernández C,Feliu JE,Simó R,García-Dorado D,Villena JA

    更新日期：2016-07-15 00:00:00

  • Peroxisome proliferator-activated receptor-α agonists modulate CXCL9 and CXCL11 chemokines in Graves' ophthalmopathy fibroblasts and preadipocytes.

    abstract：:Peroxisome proliferator-activated receptors (PPAR)α have been shown to exert immunomodulatory effects in autoimmune disorders; no study evaluated the effect of PPARα activation in Graves' ophthalmopathy (GO). We show the presence of PPARα, δ and γ in GO fibroblasts and preadipocytes. PPARα activators have a potent inh...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.11.001

    authors： Antonelli A,Ferrari SM,Frascerra S,Ruffilli I,Gelmini S,Minuto M,Pupilli C,Miccoli P,Sellari-Franceschini S,Ferrannini E,Fallahi P

    更新日期：2012-02-26 00:00:00

  • A monoclonal antibody which inhibits the biological activity of rat prolactin, but not prolactin from other species.

    abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90249-8

    authors： Scammell JG,Wear LB,Von Haven R

    更新日期：1990-06-18 00:00:00

  • Human corticotropin-releasing factor type 1 receptor analysis with white blood cells mRNAs and DNA.

    abstract：:The human corticotropin-releasing factor receptor type 1 (hCRF-R1) functional transcript is mainly expressed in the anterior pituitary corticotrophs, a tissue usually not available for clinical investigation. Splice variants translated into defective isoforms of the receptor have been described in few peripheral tissu...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00359-3

    authors： Ben Simon E,Besancon R,Benetollo C,Nicolino M,Saez JM,Li JY

    更新日期：2003-01-31 00:00:00

  • Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells.

    abstract：:The distribution of the steroidogenic acute regulatory protein (StAR) inside thecal and granulosa-lutein cells of human corpus luteum (CL) was assessed by immunoelectron microscopy. We found greater levels of StAR immunolabeling in steroidogenic cells from early- and mid-than in late luteal phase CL and lower levels i...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.08.003

    authors： Sierralta WD,Kohen P,Castro O,Muñoz A,Strauss JF 3rd,Devoto L

    更新日期：2005-10-20 00:00:00

  • Estrogen receptor mutations.

    abstract：:The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(98)00170-1

    authors： Taylor JA,Lewis KJ,Lubahn DB

    更新日期：1998-10-25 00:00:00

  • Point mutations abolish 11 beta-hydroxysteroid dehydrogenase type II activity in three families with the congenital syndrome of apparent mineralocorticoid excess.

    abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol into mineralocorticoid receptor inactive cortisone, thus preventing occupation of the non-selective mineralocorticoid receptor by glucocorticoids in the kidney. Mutations generating inactive enzymes have been described in the HSD1...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03787-2

    authors： Ferrari P,Obeyesekere VR,Li K,Wilson RC,New MI,Funder JW,Krozowski ZS

    更新日期：1996-05-17 00:00:00

  • Relaxin-like factor (RLF) mRNA expression in the fallow deer.

    abstract：:Employing RT- and RACE-PCR on RNA isolated from testicular tissue, we have cloned the coding cDNA sequence for the RLF, also known as Insl3, of the fallow deer. The RLF coding sequence consisted of 396 bp encoding a peptide of 131 amino acids and shared highest homology with bovine, sheep and goat RLF. Northern analys...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00190-2

    authors： Hombach-Klonisch S,Kauffold J,Rautenberg T,Steger K,Tetens F,Fischer B,Klonisch T

    更新日期：2000-01-25 00:00:00

  • Partial characterization of somatomedin C-like immunoreactivity secreted by breast cancer cells in vitro.

    abstract：:The in vitro secretion of immunoreactive somatomedin C/insulin-like growth factor I (IR Sm-C/IGF-I) by two human breast cancer cell lines, MCF-7 and EVSA-T has been studied. IR Sm-C/IGF-I concentration showed a linear increase in serum-free culture media over 72 h of incubation for both cell lines, and a close correla...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90155-9

    authors： Minuto F,Del Monte P,Barreca A,Nicolin A,Giordano G

    更新日期：1987-12-01 00:00:00

  • Participation of NADPH 4 oxidase in thyroid regulation.

    abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.10.012

    authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

    更新日期：2019-01-15 00:00:00

  • Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells.

    abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90260-d

    authors： Patel KV,Schrey MP

    更新日期：1992-06-01 00:00:00

  • A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway.

    abstract：:Adipose tissue-derived adipokines play important roles as regulators of skeletal growth and development. CTRP1, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. It is expressed at high levels in adipose tissue and has recently emerged as a novel adipo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.01.002

    authors： Akiyama H,Otani M,Sato S,Toyosawa S,Furukawa S,Wakisaka S,Maeda T

    更新日期：2013-04-30 00:00:00

  • Immunocytochemical localization of inhibin in rat and human reproductive tissues.

    abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90162-6

    authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

    更新日期：1987-12-01 00:00:00

  • Somatostatin signaling and the regulation of growth and metabolism in fish.

    abstract：:The study of the somatostatins (SS) signaling system in fish has provided important information about the structure, function, and evolution of SSs and their receptors. The SS signaling system elicits widespread biological actions via multiple hormone variants, numerous receptor subtypes, and a variety of signal trans...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2007.08.010

    authors： Klein SE,Sheridan MA

    更新日期：2008-05-14 00:00:00

  • Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation.

    abstract：:alpha-Fetoprotein (AFP) is a serum protein expressed during fetal life, the expression of which is shut off after birth. The activity of the mouse Afp gene promoter region comprised between -80 and -38 bp is regulated by the thyroid hormone receptor (T3R): negatively in the presence of T3 and positively in the absence...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00739-0

    authors： Van Reeth T,Gabant P,Szpirer C,Szpirer J

    更新日期：2002-02-25 00:00:00

  • GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant.

    abstract：:The introduction of a targeted insertion mutation into exon 2 of the gene coding for the glucocorticoid receptor (GR) enabled production of glucocorticoid receptor knock-out (GRKO) mice. GRKO mice on a C57BL/6/129sv mixed genetic background show a variable phenotype, with 90% of -/- mice dying at birth with respirator...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00407-x

    authors： Cole TJ,Myles K,Purton JF,Brereton PS,Solomon NM,Godfrey DI,Funder JW

    更新日期：2001-02-28 00:00:00

  • Specificity of the cyclic GMP-binding activity and of a cyclic GMP-dependent cyclic GMP phosphodiesterase in Dictyostelium discoideum.

    abstract：:The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90050-8

    authors： van Haastert PJ,van Walsum H,van der Meer RC,Bulgakov R,Konijn TM

    更新日期：1982-02-01 00:00:00

  • Retinoic acid induction of the tissue transglutaminase promoter is mediated by a novel response element.

    abstract：:We recently cloned and sequenced two kilobases of the upstream flanking region of the mouse tissue transglutaminase gene. Transfection experiments showed that this region of the transglutaminase flanking sequence was sufficient to mediate a 4-fold induction in reporter gene expression by retinoic acid. The goal of the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03826-9

    authors： Yan ZH,Noonan S,Nagy L,Davies PJ,Stein JP

    更新日期：1996-07-01 00:00:00

  • Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis.

    abstract：:Our previous studies have provided evidence for the existence of an intrinsic renin-angiotensin system (RAS) in the rat pancreas, which may play a role in the regulation of pancreatic microcirculation and ductal secretion. Such a pancreatic RAS has recently shown to be activated by chronic hypoxia. The activation of a...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00275-6

    authors： Leung PS,Chan WP,Nobiling R

    更新日期：2000-08-30 00:00:00

  • Glucocorticoid receptor gene expression in rat pituitary gland intermediate lobe following ovariectomy.

    abstract：:Using hybridization techniques and Northern blots we have identified a approximately 6.5 kb glucocorticoid receptor mRNA species in rat pituitary intermediate lobe. Glucocorticoid receptor mRNA concentrations, which are barely detectable or undetectable in normal animals, were greatly increased following ovariectomy. ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90125-6

    authors： Pfeiffer A,Barden N

    更新日期：1988-02-01 00:00:00

  • Is human chorionic gonadotropin directly involved in the regulation of human implantation?

    abstract：:The regulation of human implantation is not fully understood. hCG as one of the earliest embryonal signals may be a major regulator in the parakrine embryo-endometrial communication. The expression of full-length hCG/LH-receptor mRNA could be demonstrated in human endometrium throughout the follicular and secretory ph...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2006.09.016

    authors： Licht P,Fluhr H,Neuwinger J,Wallwiener D,Wildt L

    更新日期：2007-04-15 00:00:00

  • Developmental programming: Adipose depot-specific changes and thermogenic adipocyte distribution in the female sheep.

    abstract：:Prenatal testosterone (T)-treated female sheep exhibit an enhanced inflammatory and oxidative stress state in the visceral adipose tissue (VAT) but not in the subcutaneous (SAT), while surprisingly maintaining insulin sensitivity in both depots. In adult sheep, adipose tissue is predominantly composed of white adipocy...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2019.110691

    authors： Puttabyatappa M,Ciarelli JN,Chatoff AG,Singer K,Padmanabhan V

    更新日期：2020-03-01 00:00:00

  • Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice.

    abstract：:Apolipoprotein E (APOE) deficient mice exhibit unexplained hypercorticosteronemia. Given that APOE is also produced locally within the adrenals, we evaluated the effect of adrenal-specific APOE deficiency on the glucocorticoid function. Hereto, one adrenal containing or lacking APOE was transplanted into adrenalectomi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2019.04.001

    authors： van der Sluis RJ,Depuydt MAC,Verwilligen RAF,Hoekstra M,Van Eck M

    更新日期：2019-06-15 00:00:00

  • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells.

    abstract：:While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00254-3

    authors： Thoennes SR,Tate PL,Price TM,Kilgore MW

    更新日期：2000-02-25 00:00:00

  • The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes.

    abstract：:Recently fibroblast growth factor 21 (FGF21) has been identified as a potent regulator in glucose and lipid homeostasis. Here, we firstly investigated the metabolic role of FGF21 in human liver-derived HepG2 cells, and suggested that overexpression of FGF21 suppressed triglyceride accumulation by inhibiting the transc...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.05.003

    authors： Zhang Y,Lei T,Huang JF,Wang SB,Zhou LL,Yang ZQ,Chen XD

    更新日期：2011-08-06 00:00:00

  • Osmolytes improve the reconstitution of luteinizing hormone/human chorionic gonadotropin receptors into proteoliposomes.

    abstract：:Rat ovarian membrane luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor was reconstituted into proteoliposomes. The ability of sodium cholate to extract and reconstitute hCG binding activity was dependent on the protein/detergent ratio. Trypsinization of the LH/hCG receptor containing proteoliposomes i...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90160-8

    authors： Kolena J,Matejcíková K,Srenkelová G

    更新日期：1992-02-01 00:00:00

  • Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.

    abstract：:We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps deliv...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00681-5

    authors： Haberkorn V,Heydel JM,Mounie J,Artur Y,Goudonnet H

    更新日期：2002-04-25 00:00:00

  • Elements involved in the regulation of the StAR gene.

    abstract：:The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(01)00423-3

    authors： Stocco DM,Clark BJ,Reinhart AJ,Williams SC,Dyson M,Dassi B,Walsh LP,Manna PR,Wang XJ,Zeleznik AJ,Orly J

    更新日期：2001-05-25 00:00:00