Elements involved in the regulation of the StAR gene.

abstract：:The seminal vesicles of male rat secrete tissue-specific proteins under androgenic control. The effects of testosterone on the rough endoplasmic reticulum (RER) and Golgi-system of this tissue have been quantified using specific antibodies. Castration was followed within 2 weeks by a 10-fold reduction in RER-specific ...

journal_title：Molecular and cellular endocrinology

authors： Fawell SE,Higgins SJ

更新日期：1984-08-01 00:00:00

abstract：:When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accum...

journal_title：Molecular and cellular endocrinology

authors： Verhoeven G,Cailleau J,de Moor P

更新日期：1980-11-01 00:00:00

abstract：:A cell culture line has been derived from lymphosarcoma P1798. Cells will not divide in the prescence of 10(-8) M dexamethasone. Half-maximal inhibition of proliferation occurs at about 10(-9) M. Half-maximal inhibition of [3H] thymidine incorporation occurs at somewhat higher concentrations of dexamethasone. When cel...

journal_title：Molecular and cellular endocrinology

authors： Thompson EA Jr

更新日期：1980-02-01 00:00:00

abstract：:Transcription elongation of many eukaryotic genes is regulated. Two negative transcription elongation factors, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) are known to stall collaboratively RNA polymerase II promoter proximally. We dis...

journal_title：Molecular and cellular endocrinology

authors： Fujita T,Piuz I,Schlegel W

更新日期：2010-05-05 00:00:00

abstract：:To fully evaluate the advantages of a cryopreservation program a method needs to be established to express the additional patients pregnant from cryopreservation. The patient specific method considers cryopreservation as augmentation only among patients without a pregnancy from the fresh transfer, or from previously t...

journal_title：Molecular and cellular endocrinology

authors： Schnorr JA,Muasher SJ,Jones HW Jr

更新日期：2000-11-27 00:00:00

abstract：:Thyroid hormone receptor alpha (TRalpha) and the oncoprotein v-erbA (a mutated form of TRalpha incapable of binding T3) bind as heterodimers with retinoid X receptor (RXR) to DNA sequences with different orientations of AGGTCA half sites. v-erbA can also form homodimers, whereas, TRalpha1 homodimerizes poorly. Therefo...

journal_title：Molecular and cellular endocrinology

authors： Zubkova I,Subauste JS

更新日期：2003-01-31 00:00:00

abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is essential for the biosynthesis of all active steroid hormones. The 3beta-HSD enzyme consists in multiple isoforms, each the product of a distinct gene. In the mouse, six tissue-specific isoforms have been identified. These isoforms are expressed in...

journal_title：Molecular and cellular endocrinology

authors： Peng L,Arensburg J,Orly J,Payne AH

更新日期：2002-02-22 00:00:00

abstract：:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to m...

journal_title：Molecular and cellular endocrinology

authors： Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

更新日期：2011-12-05 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00

abstract：:Subjects with androgen insensitivity syndromes (AIS) are characterized by a 46, XY karyotype, presence of testes, normal or elevated androgen levels in blood, and impairment of the usual response to androgens associated with various aberrations of male differentiation and virilization ranging from slightly undervirili...

journal_title：Molecular and cellular endocrinology

authors： Peters I,Weidemann W,Romalo G,Knorr D,Schweikert HU,Spindler KD

更新日期：1999-02-25 00:00:00

abstract：:Corticotropin-releasing factor (CRF) receptor type 1 (CRF(1) receptor) mRNA levels are down-regulated by CRF via the cyclic AMP-protein kinase A (PKA) pathway. In this study, we focused on the involvement of both the mitogen-activated protein (MAP) kinase pathway and PKA in this regulation. Real-time PCR (RT-PCR) reve...

journal_title：Molecular and cellular endocrinology

authors： Moriyama T,Kageyama K,Kasagi Y,Iwasaki Y,Nigawara T,Sakihara S,Suda T

更新日期：2005-11-24 00:00:00

abstract：:Several lines of evidence indicate that the number of GnRH receptors (GnRH-R) and therefore, gonadotrope responsiveness to GnRH, is highly dependent upon the level of GnRH-R mRNA. To explore this aspect of regulation, we have isolated a 3.3 kb fragment encompassing the promoter region of the rat GnRH-R gene. Primer ex...

journal_title：Molecular and cellular endocrinology

authors： Pincas H,Forraï Z,Chauvin S,Laverrière JN,Counis R

更新日期：1998-09-25 00:00:00

abstract：:The identification of estrogen-responsive genes in the heart, is necessary to understand estrogen-induced changes in cardiac function. Using Delta RNA fingerprinting, we demonstrate that a single injection of estradiol benzoate (50 microg, s.c.) revealed mRNA species that were elevated, down-regulated, or were unaffec...

journal_title：Molecular and cellular endocrinology

authors： Too CK,Giles A,Wilkinson M

更新日期：1999-04-25 00:00:00

abstract：:Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation emb...

journal_title：Molecular and cellular endocrinology

authors： You JL,Wang W,Tang MY,Ye YH,Liu AX,Zhu YM

更新日期：2018-07-15 00:00:00

abstract：:Adrenocortical tumor (ACT), a rare tumor with a heterogeneous presentation, incompletely understood pathogenesis, and generally poor prognosis, occurs in 1-2 people per million and is even more uncommon in the pediatric population. Such rare cancers are a challenge to clinical practice. Exchange of experience, informa...

journal_title：Molecular and cellular endocrinology

authors： Ribeiro RC,Pinto EM,Zambetti GP,Rodriguez-Galindo C

更新日期：2012-03-31 00:00:00

abstract：:The human choriocarcinoma cell line, BeWo, synthesizes the glycoprotein hormone, human chorionic gonadotropin (hCG). We have undertaken this study to compare the synthesized and secreted forms of hCG and their alpha- and beta-subunits in cell cultures of BeWo cells to those forms of normal placental cells by immunobin...

journal_title：Molecular and cellular endocrinology

authors： Takeuchi Y,Sakakibara R,Ishiguro M

更新日期：1990-03-05 00:00:00

abstract：:Glucocorticoids play a major role in attenuation of the inflammatory response. These steroid hormones are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages and T-lymphocytes that are involved in the inflammation reaction. In contrast, it was discovered recently that in glandu...

journal_title：Molecular and cellular endocrinology

authors： Amsterdam A,Sasson R

更新日期：2002-03-28 00:00:00

abstract：:Photo-affinity labelling of MSH receptors on tail-fin melanophores of Xenopus tadpoles with p-azidophenylalanine 13-alpha-MSH (Pap13)-alpha-MSH) or p-azidophenylacetyl-serine1-alpha-MSH ([Apac-Ser1]-alpha-MSH) resulted in a long-lasting stimulation of the melanophores which cannot be reversed despite continuous washin...

journal_title：Molecular and cellular endocrinology

authors： de Graan PN,Eberle AN,van de Veerdonk FC

更新日期：1982-05-01 00:00:00

abstract：:Human type II iodothyronine deiodinase (hDII) belongs to a family of selenoproteins. It catalyzes 5'-deiodination of thyroxine to generate an active thyroid hormone, 3,3',5-triiodothyronine. Two novel splice variants of hDII gene transcript; namely hDII-b and hDII-c, were identified. Three distinct DNA fragments (hDII...

journal_title：Molecular and cellular endocrinology

authors： Ohba K,Yoshioka T,Muraki T

更新日期：2001-02-14 00:00:00

abstract：:Environmental conditions in early life permanently alter the development of glucocorticoid receptor gene expression in the hippocampus and hypothalamic-pituitary-adrenal responses to acute or chronic stress. In part, these effects can involve an activation of ascending serotonergic pathways and subsequent changes in t...

journal_title：Molecular and cellular endocrinology

authors： Weaver IC,La Plante P,Weaver S,Parent A,Sharma S,Diorio J,Chapman KE,Seckl JR,Szyf M,Meaney MJ

更新日期：2001-12-20 00:00:00

abstract：:Adenomas and nodules of the human adrenal cortex are common, whereas adrenocortical carcinomas are rare. Genes such as IGF2 have been suggested to be important in human adrenocortical tumorigenesis but their role has not been directly investigated. We describe here elements of a system in which hypotheses concerning t...

journal_title：Molecular and cellular endocrinology

authors： Cardoso CC,Bornstein SR,Hornsby PJ

更新日期：2009-03-05 00:00:00

abstract：:Phospholipase C (PHL-C) activity determined in homogenates of fat cells treated with physiological concentrations of insulin showed a 2-3-fold increase as compared to controls in the absence of insulin. The changes of PHL-C and pyruvate dehydrogenase (PDH) activity which was measured concomitantly exhibited very simil...

journal_title：Molecular and cellular endocrinology

authors： Koepfer-Hobelsberger B,Wieland OH

更新日期：1984-06-01 00:00:00

abstract：:Osteoblastic metastases are common in patients with advanced prostate cancer. The pathophysiology of the new bone formation at metastatic sites is not currently known, but it is hypothesized that growth factors secreted by the prostate may be involved. Unfortunately, most rodent models of prostate cancer with metastas...

journal_title：Molecular and cellular endocrinology

authors： LeRoy BE,Bahnson RR,Rosol TJ

更新日期：2002-11-29 00:00:00

abstract：:We recently cloned and sequenced two kilobases of the upstream flanking region of the mouse tissue transglutaminase gene. Transfection experiments showed that this region of the transglutaminase flanking sequence was sufficient to mediate a 4-fold induction in reporter gene expression by retinoic acid. The goal of the...

journal_title：Molecular and cellular endocrinology

authors： Yan ZH,Noonan S,Nagy L,Davies PJ,Stein JP

更新日期：1996-07-01 00:00:00

abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

journal_title：Molecular and cellular endocrinology

authors： Kurosu H,Kuro-O M

更新日期：2009-02-05 00:00:00

abstract：:Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II). These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I). Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to bind...

journal_title：Molecular and cellular endocrinology

authors： Koeffler HP,Bishop JE,Reichel H,Singer F,Nagler A,Tobler A,Walka M,Norman AW

更新日期：1990-03-26 00:00:00

abstract：:The synthesis and phosphorylation of H1 histones were studied in organ cultures of midpregnant mouse mammary glands exposed to various combinations of insulin, cortisol and prolactin over a 48-h period. The synthesis of specific H1 histone subtypes was changed only when all three hormones were present, and the effect ...

journal_title：Molecular and cellular endocrinology

authors： Hohmann P,Hughes C

更新日期：1987-11-01 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00

abstract：:The rate of dissociation of recombinant, purified human estrogen receptor alpha (ERalpha) from a fluorescein-labeled DNA containing the consensus vitellogenin ERE sequence (F-vitERE) was determined in real time using fluorescence anisotropy. The complex of estradiol-occupied ERalpha with F-vitERE had an apparent disso...

journal_title：Molecular and cellular endocrinology

authors： Szatkowski Ozers M,Hill JJ,Ervin K,Royer CA,Gorski J

更新日期：2001-04-25 00:00:00

abstract：:Adiponectin, an adipose-secreted adipocytokine, exhibits various metabolic functions but has no known effect on bone development through the growth plate and specifically, in chondrocytes. Using the mouse ATDC5 cell line, a widely used in vitro model of chondrogenesis, we demonstrated the expression of adiponectin and...

journal_title：Molecular and cellular endocrinology

authors： Challa TD,Rais Y,Ornan EM

更新日期：2010-07-29 00:00:00