当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Desensitization of cultured rat Sertoli cells by follicle-stimulating hormone and by L-isoproterenol.

Desensitization of cultured rat Sertoli cells by follicle-stimulating hormone and by L-isoproterenol.

Abstract：

:When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accumulates in the medium and in the cells. The extent of desensitization depends on the concentration of FSH or L-isoproterenol to which the cells have been exposed and on the duration of this previous contact. Pre-incubation with FSH results in cross-desensitization for L-isoproterenol. Comparable heterologous desensitization is not observed after pre-incubation with L-isoproterenol. This suggests that down-regulation of the respective receptors cannot be the only explanation. Refractoriness can also be induced by dbcAMP. This opens the possibility that cAMP itself contributes to the homologous and heterologous desensitization process.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Verhoeven G,Cailleau J,de Moor P

doi

10.1016/0303-7207(80)90075-1

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

113-26

issue

2

eissn

0303-7207

issn

1872-8057

pii

0303-7207(80)90075-1

journal_volume

20

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Upstream open reading frames regulate cannabinoid receptor 1 expression under baseline conditions and during cellular stress.

    abstract：:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.09.019

    authors： Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

    更新日期：2015-01-05 00:00:00

  • Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells.

    abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90260-d

    authors： Patel KV,Schrey MP

    更新日期：1992-06-01 00:00:00

  • Coordinate estrogen induction of vitellogenin and a small serum protein mRNA in Xenopus laevis liver.

    abstract：:We have used plus-minus hybridization to identify Xenopus liver cDNA clones of mRNAs whose levels are regulated by estrogen. One clone identified in this way was shown to be a nearly full-length cDNA clone of the mRNA coding for a small 22 000 dalton estrogen-inducible serum protein (EISP). Quantitation of EISP mRNA l...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(85)90124-8

    authors： Hayward MA,Barton MC,Shapiro DJ

    更新日期：1985-02-01 00:00:00

  • Effects of GH/IGF axis on bone and cartilage.

    abstract：:Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have been studied in many tissues and organs over decades. GH and IGF-1 are part of the hypothalamic/pituitary somatotrophic axis that consists of man...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2020.111052

    authors： Dixit M,Poudel SB,Yakar S

    更新日期：2021-01-01 00:00:00

  • Parathyroid hormone acute vascular effect is mediated by decreased Ca2+ uptake and enhanced cAMP level.

    abstract：:Cardiovascular effects of parathyroid hormone (PTH) have been recently described. Pharmacological doses of PTH both reduce arterial pressure and increase blood flow of vascular beds. Two possible cellular mechanisms were investigated: (a) transmembrane Ca2+ fluxes and (b) cyclic AMP response in vascular smooth muscle....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90231-1

    authors： Schleiffer R,Bergmann C,Pernot F,Gairard A

    更新日期：1989-11-01 00:00:00

  • Src enhances osteogenic differentiation through phosphorylation of Osterix.

    abstract：:Osterix, a zinc-finger transcription factor, is required for osteoblast differentiation and new bone formation during embryonic development. The c-Src of tyrosine kinase is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganizati...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.03.010

    authors： Choi YH,Han Y,Lee SH,Cheong H,Chun KH,Yeo CY,Lee KY

    更新日期：2015-05-15 00:00:00

  • Characterization of 17 beta-hydroxysteroid dehydrogenase type 1 in choriocarcinoma cells: regulation by basic fibroblast growth factor.

    abstract：:17 beta-Hydroxysteroid dehydrogenase type 1 (17-HSD type 1) is a steroidogenic enzyme catalyzing reversible interconversion of estradiol and estrone. 17-HSD type 1 is actively expressed in human placenta. We characterized 17-HSD type 1 expression and its regulation by basic fibroblast growth factor (bFGF) in JAR, JEG-...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(94)90045-0

    authors： Lewintre EJ,Orava M,Peltoketo H,Vihko R

    更新日期：1994-08-01 00:00:00

  • The Klotho gene family as a regulator of endocrine fibroblast growth factors.

    abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.10.052

    authors： Kurosu H,Kuro-O M

    更新日期：2009-02-05 00:00:00

  • Hormonal regulation of early follicle development in the rat ovary.

    abstract：:Although earlier studies focused on the hormonal regulation of antral and preovulatory follicles, recent studies indicate the importance of the hormonal control mechanism for preantral follicles. The endocrine hormone FSH is not only a survival factor for early antral follicles but also a potent growth and differentia...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(99)00245-2

    authors： Hsueh AJ,McGee EA,Hayashi M,Hsu SY

    更新日期：2000-05-25 00:00:00

  • Adrenal deficiency alters mechanisms of neutrophil mobilization.

    abstract：:Deficiency of adrenal hormones promotes exacerbated neutrophil influx into inflammatory sites. We investigated the effect of adrenal deficiency on neutrophil mobilization comparing adrenalectomized (ADX) male Wistar rats to sham-operated (SO) or non-manipulated (N) animals, as controls. Seven days after surgeries, the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.01.007

    authors： Cavalcanti DM,Lotufo CM,Borelli P,Tavassi AM,Pereira AL,Markus RP,Farsky SH

    更新日期：2006-04-25 00:00:00

  • Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells.

    abstract：:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.10.006

    authors： Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

    更新日期：2015-01-05 00:00:00

  • LHR splicing variants and gene expression in the marmoset monkey.

    abstract：:In the marmoset monkey, the LHR type II, lacking exon 10, is the native receptor type. We characterised the LHR splicing pattern in marmoset testes and the adrenals during puberty and in pre- and postpubertal ovaries and quantified mRNA LHR expression in the testis. We detected 11 LHR splicing variants expressed at si...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.08.009

    authors： Michel C,Gromoll J,Chandolia R,Luetjens CM,Wistuba J,Simoni M

    更新日期：2007-12-15 00:00:00

  • Ghrelin in eating disorders.

    abstract：:Ghrelin is the only known circulating hormone that acts on peripheral and central targets to increase food intake and promote adiposity. The present review focuses on the possible clinical relevance of ghrelin in the regulation of human feeding behavior in individuals with obesity and other eating disorders such as Pr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2011.03.001

    authors： Yi CX,Heppner K,Tschöp MH

    更新日期：2011-06-20 00:00:00

  • FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling.

    abstract：:Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated d-glucose that Akt1 and the post-translational modif...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.02.037

    authors： Hou J,Chong ZZ,Shang YC,Maiese K

    更新日期：2010-06-10 00:00:00

  • Inhibition of proteoglycan synthesis induces an increase in follicle stimulating hormone (FSH)-stimulated estradiol production by immature rat Sertoli cells.

    abstract：:In order to define the possible involvement of proteoglycans (PG) in the regulation of Sertoli cell functions, we have examined the effect of para-nitrophenyl-beta-D-xyloside (PNPX), a specific inhibitor of PG synthesis, on follicle stimulating hormone (FSH)-dependent estradiol production by immature rat Sertoli cells...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03483-n

    authors： Phamantu NT,Bonnamy PJ,Bouakka M,Bocquet J

    更新日期：1995-03-01 00:00:00

  • Octreotide and pasireotide effects on medullary thyroid carcinoma (MTC) cells growth, migration and invasion.

    abstract：:Medullary thyroid carcinoma (MTC) is a rare neuroendocrine neoplasm of the parafollicular thyroid C cells. Although somatostatin receptors are expressed by MTCs, treatment with octreotide has shown poor efficacy, whereas recently pasireotide has demonstrated antiproliferative effects in persistent postoperative MTCs. ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2020.111092

    authors： Giardino E,Catalano R,Mangili F,Barbieri AM,Treppiedi D,Elli FM,Dolci A,Contarino A,Spada A,Arosio M,Mantovani G,Peverelli E

    更新日期：2021-01-15 00:00:00

  • Mineralocorticoid receptor and embryonic stem cell models: molecular insights and pathophysiological relevance.

    abstract：:Mineralocorticoid receptor (MR) signaling is pivotal for numerous physiological processes and implicated in various pathological conditions concerning among others, tight epithelia, central nervous and cardiovascular systems. For decades, the pleiotropic actions of MR have been investigated using animal and cellular m...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2011.06.036

    authors： Le Menuet D,Munier M,Campostrini G,Lombès M

    更新日期：2012-03-24 00:00:00

  • Human FSH isoforms: carbohydrate complexity as determinant of in-vitro bioactivity.

    abstract：:Differences in sialic acid content of the hormone have been considered the main determinant of FSH polymorphism. The aim of the present study was to investigate the effect of variations in the oligosaccharide structure of the intrapituitary human FSH (hFSH) glycosylation variants on their intrinsic biological activity...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00453-6

    authors： Creus S,Chaia Z,Pellizzari EH,Cigorraga SB,Ulloa-Aguirre A,Campo S

    更新日期：2001-03-28 00:00:00

  • 1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5.

    abstract：:While vitamin D supplementation is common, the anabolic mechanisms that improve bone status are poorly understood. Under standard mineralising conditions including media ionised calcium of 1.1 mM, 1,25-dihydroxyvitamin D3 (1,25D) enhanced differentiation and mineral deposition by the mature osteoblast/pre-osteocyte ce...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.06.005

    authors： Yang D,Turner AG,Wijenayaka AR,Anderson PH,Morris HA,Atkins GJ

    更新日期：2015-09-05 00:00:00

  • Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.

    abstract：:Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.11.025

    authors： Papaconstantinou J

    更新日期：2009-02-05 00:00:00

  • Stromal cells from the rat prostate secrete androgen-regulated factors which modulate Sertoli cell function.

    abstract：:Testicular peritubular cells produce paracrine mediators which modulate Sertoli cell function. The production of these mediators (P Mod-S) is controlled by androgens suggesting that mesenchymal-epithelial interactions play an important role in androgen action in the testis. We investigated whether mesenchymal cells fr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90124-x

    authors： Swinnen K,Cailleau J,Heyns W,Verhoeven G

    更新日期：1989-03-01 00:00:00

  • Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.

    abstract：:Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcuta...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.10.004

    authors： Rodriguez-Sosa JR,Bondareva A,Tang L,Avelar GF,Coyle KM,Modelski M,Alpaugh W,Conley A,Wynne-Edwards K,França LR,Meyers S,Dobrinski I

    更新日期：2014-12-01 00:00:00

  • Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization.

    abstract：:Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role d...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.08.011

    authors： Zhang XH,Liang X,Wang TS,Liang XH,Zuo RJ,Deng WB,Zhang ZR,Qin FN,Zhao ZA,Yang ZM

    更新日期：2013-12-05 00:00:00

  • Fourier analysis of differential light scattering for the quantitation of FSH response associated with structural changes in immortalized granulosa cells.

    abstract：:We have established granulosa cell lines which express constitutively the rat FSH receptors by cotransfection of primary granulosa cells obtained from preovulatory follicles with SV40 DNA, Ha-ras oncogene and a plasmid expressing FSH receptors. These cells respond specifically to ovine and human FSH by cell rounding, ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03774-4

    authors： Schiffer Z,Keren-Tal I,Deutsch M,Dantes A,Aharoni D,Weinerb A,Tirosh R,Amsterdam A

    更新日期：1996-04-19 00:00:00

  • Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer.

    abstract：:Inhibin is a member of the TGF-beta superfamily of growth and differentiation factors and a tumor suppressor. Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of heterozygosity (LOH) as well as dow...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2004.02.015

    authors： Risbridger GP,Ball EM,Wang H,Mellor SL,Peehl DM

    更新日期：2004-10-15 00:00:00

  • Multifunctionality of human 17beta-hydroxysteroid dehydrogenases.

    abstract：:17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. Durin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.11.031

    authors： Moeller G,Adamski J

    更新日期：2006-03-27 00:00:00

  • Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.

    abstract：:17Beta hydroxysteroid dehydrogenase type 7 (HSD17B7) was described to possess dual functionality in steroidogenesis as well as in postsqualene cholesterol biosynthesis in vitro. In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.10.016

    authors： Ohnesorg T,Adamski J

    更新日期：2006-03-27 00:00:00

  • Directional secretion and transport of leptin and expression of leptin receptor isoforms in human placental BeWo cells.

    abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.05.003

    authors： Wyrwoll CS,Mark PJ,Waddell BJ

    更新日期：2005-09-28 00:00:00

  • Mouse insulin-like growth factor binding protein-6: expression, purification, characterization and histochemical localization.

    abstract：:The mitogenic and metabolic activities of insulin-like growth factors (IGF) are modulated by a family of six high affinity IGF binding proteins (IGFBPs). This study describes the expression of the mouse IGFBP-6 which is unique among IGFBPs in its preferential binding of IGF II, in insect cells using the baculovirus sy...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(97)00233-5

    authors： Putzer P,Breuer P,Götz W,Gross M,Kübler B,Scharf JG,Schuller AG,Hartmann H,Braulke T

    更新日期：1998-02-01 00:00:00

  • Genetic modifications of mouse proopiomelanocortin peptide processing.

    abstract：:Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to pigmentation to the regulation of feeding. One approach to unraveling the complexi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.12.032

    authors： Costa JL,Forbes S,Brennan MB,Hochgeschwender U

    更新日期：2011-04-10 00:00:00