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Vitamin D metabolism within bone cells: effects on bone structure and strength.

Abstract：

:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

doi

10.1016/j.mce.2011.05.024

subject

Has Abstract

pub_date

2011-12-05 00:00:00

pages

42-7

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(11)00276-0

journal_volume

347

pub_type

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