Abstract：
:Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose is too high, risking ovarian hyperstimulation syndrome. A major improvement to this approach would, therefore, be the ability to use initial screening characteristics to assess the individual FSH threshold beforehand. For IVF treatment, interfering in the process of single dominant follicle selection in ovulatory women by late follicular phase administration of low doses of FSH may result in a significantly reduced duration of stimulation and amounts of exogenous FSH preparations used. Less monitoring would be required and chances for short-term complications or long term risks may be reduced.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Macklon NS,Fauser BCdoi
10.1016/s0303-7207(01)00660-8keywords:
subject
Has Abstractpub_date
2002-01-25 00:00:00pages
159-61issue
2eissn
0303-7207issn
1872-8057pii
S0303720701006608journal_volume
186pub_type
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