Abstract:
:Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global epidemic has encouraged ongoing research to characterize the mechanisms underlying obesity and its comorbidities. Recent evidence suggests that saturated fatty acids (SFA) in high-fat diets rapidly generate inflammation in the arcuate nucleus of the hypothalamus (ARC), which centrally regulates whole-body energy homeostasis. Herein, we will review the roles of hypothalamic neurons and resident microglia in the initiation of SFA-induced hypothalamic inflammation. Particularly, we focus on neuronal and microglial free fatty acid-sensing and capacity to produce inflammatory signaling. We also outline a potential role of peripherally-derived monocytes in this inflammation. And finally, we explore synaptic plasticity as a mechanism through which hypothalamic inflammation can modulate ARC circuitry, and thus disrupt energy homeostasis.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Tran DQ,Tse EK,Kim MH,Belsham DDdoi
10.1016/j.mce.2016.05.015subject
Has Abstractpub_date
2016-12-15 00:00:00pages
18-26eissn
0303-7207issn
1872-8057pii
S0303-7207(16)30164-2journal_volume
438pub_type
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
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