当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue.

The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue.

Abstract：

:Cyclosporin A (CsA), tacrolimus and rapamycin are immunosuppressive agents (IAs) associated with insulin resistance and dyslipidemia, although their molecular effects on lipid metabolism in adipose tissue are unknown. We explored IAs effects on lipolysis, lipid storage and expression of genes involved on lipid metabolism in isolated human adipocytes and/or adipose tissue obtained via subcutaneous and omental fat biopsies. CsA, tacrolimus and rapamycin increased isoproterenol-stimulated lipolysis and inhibited lipid storage by 20-35% and enhanced isoproterenol-stimulated hormone-sensitive lipase Ser552 phosphorylation. Rapamycin also increased basal lipolysis (~20%) and impaired insulin's antilipolytic effect. Rapamycin, down-regulated the gene expression of perilipin, sterol regulatory element-binding protein 1 (SREBP1) and lipin 1, while tacrolimus down-regulated CD36 and aP2 gene expression. All three IAs increased IL-6 gene expression and secretion, but not expression and secretion of TNF-α or adiponectin. These findings suggest that CsA, tacrolimus and rapamycin enhance lipolysis, inhibit lipid storage and expression of lipogenic genes in adipose tissue, which may contribute to the development of dyslipidemia and insulin resistance associated with immunosuppressive therapy.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Pereira MJ,Palming J,Rizell M,Aureliano M,Carvalho E,Svensson MK,Eriksson JW

doi

10.1016/j.mce.2012.10.030

subject

Has Abstract

pub_date

2013-01-30 00:00:00

pages

260-9

issue

2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(12)00482-0

journal_volume

365

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Specific DNA binding and transactivation potential of recombinant, purified Stat5.

    abstract：:The signal transducers and activators of transcriptions (Stats) are central mediators of cytokine responses especially in hematopoietic cells. The detailed molecular mechanisms of Stat activation, particularly the role of post-translational modifications and co-operation with cellular transcription factors are subject...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00588-3

    authors： Beisenherz-Huss C,Mundt M,Herrala A,Vihko P,Schubert A,Groner B

    更新日期：2001-10-25 00:00:00

  • Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.

    abstract：:Ultraviolet radiation B stimulates both the production of vitamin D3 in the skin and the activation of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central HPA. Since the role of vitamin D3 in the regulation of the HPA is largely unknown, we investigated the impact of 1,25(OH)2D3 and...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.08.006

    authors： Wierzbicka JM,Żmijewski MA,Piotrowska A,Nedoszytko B,Lange M,Tuckey RC,Slominski AT

    更新日期：2016-12-05 00:00:00

  • Deiodination of T4 to T3 and rT3 by microsomes from normal human thyroid tissue.

    abstract：:An enzyme system capable of monodeiodinating T4 to T3 and to rT3 in a microsomal fraction of normal human thyroid tissue is characterized. The pH optimum for 5'-monodeiodination of T4 to T3 was around 7.0 The Km (apparent) for the conversion of T4 to T3 was 5.7 mumoles/l. PTU, ipodate and rT3 inhibited T4 deiodination...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90099-6

    authors： Boye N,Laurberg P

    更新日期：1984-10-01 00:00:00

  • Vitamin D and the brain: Genomic and non-genomic actions.

    abstract：:1,25(OH)2D3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal role in brain development, neurotransmission, neuroprotection and immunomodulation. However, the precise molecular mechanisms by which vitamin D exer...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2017.05.035

    authors： Cui X,Gooch H,Petty A,McGrath JJ,Eyles D

    更新日期：2017-09-15 00:00:00

  • Bypassing natural sperm selection during fertilization: the azh mutant offspring experience and the alternative of spermiogenesis in vitro.

    abstract：:Molecular aspects of spermiogenesis can be studied using mouse mutants and spermatids developed in vitro. The azh/azh mutant is an attractive model system because structural abnormalities in the sperm head and the ectopic position of the manchette are associated with tail bending and looping. Spermatids, developing an...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(01)00692-x

    authors： Kierszenbaum AL,Tres LL

    更新日期：2002-02-22 00:00:00

  • The steroidogenic effect of single-chain bovine LH analogs in cultured bovine follicular cells.

    abstract：:Single-chain gonadotropin analogs had been constructed for the purpose of structure-function studies and analog design. Incorporation of a spacer derived from the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit between the tethered subunit domains of the human gonadotropins is beneficial fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.03.011

    authors： Braw-Tal R,Pen S,Grinberg M,Nakav S,Ben-Menahem D

    更新日期：2006-06-27 00:00:00

  • Adrenal cholesterol utilization.

    abstract：:There are multiple systems for cellular cholesterol delivery for steroidogenesis, including uptake of lipoprotein-derived cholesterol via LDL receptor mediated endocytic pathways and SR-BI mediated "selective" pathways, as well as from endogenous cholesterol synthesis and the mobilization of stored cholesteryl esters....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2006.12.001

    authors： Kraemer FB

    更新日期：2007-02-01 00:00:00

  • Increased ornithine decarboxylase activity in kidneys undergoing hypertrophy in experimental diabetes.

    abstract：:Renal hypertrophy and hyperfiltration are early manifestations of human and experimental diabetes that may contribute to the late development of diabetic nephropathy. The biochemical events resulting in kidney growth in the diabetic state are completely unknown. Since growth of various tissues is accompanied by increa...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90176-7

    authors： Pedersen SB,Flyvbjerg A,Grønbaek H,Richelsen B

    更新日期：1992-07-01 00:00:00

  • Characterization of two forms of cyclic 3', 5'-adenosine monophosphate-dependent protein kinase in rat testicular interstitial cells.

    abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(76)90074-5

    authors： Podesta EJ,Dufau ML,Catt KJ

    更新日期：1976-06-01 00:00:00

  • New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes.

    abstract：:A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increas...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2012.05.013

    authors： Fujimori C,Ogiwara K,Hagiwara A,Takahashi T

    更新日期：2012-10-15 00:00:00

  • Induction of hepatic glycogen synthesis by glucocorticoids is not mediated by insulin.

    abstract：:Administration of 0.1 or 1 mg of prednisolone to fed mice caused a 5-fold activation of glycogen synthase in the liver after 3h, without significant changes in the circulating levels of glucose or insulin, or the hepatic concentration of cyclic AMP. Adrenalectomized fasted rats responded to cortisol (10 mg) with an in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90067-3

    authors： Vanstapel F,Bollen M,de Wulf H,Stalmans W

    更新日期：1982-06-01 00:00:00

  • Size matters: Associations between the androgen receptor CAG repeat length and the intrafollicular hormone milieu.

    abstract：:Granulosa cell (GC) expressed androgen receptors (AR) and intrafollicular androgens are central to fertility. The transactivating domain of the AR contains a polymorphic CAG repeat sequence, which is linked to the transcriptional activity of AR and may influence the GC function. This study aims to evaluate the effects...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.09.015

    authors： Borgbo T,Macek M Sr,Chrudimska J,Jeppesen JV,Hansen LL,Andersen CY

    更新日期：2016-01-05 00:00:00

  • Differentiation of Seminiferous Tubule-Associated Stem Cells into Leydig Cell and Myoid Cell Lineages.

    abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2021.111179

    authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

    更新日期：2021-01-27 00:00:00

  • LHR splicing variants and gene expression in the marmoset monkey.

    abstract：:In the marmoset monkey, the LHR type II, lacking exon 10, is the native receptor type. We characterised the LHR splicing pattern in marmoset testes and the adrenals during puberty and in pre- and postpubertal ovaries and quantified mRNA LHR expression in the testis. We detected 11 LHR splicing variants expressed at si...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.08.009

    authors： Michel C,Gromoll J,Chandolia R,Luetjens CM,Wistuba J,Simoni M

    更新日期：2007-12-15 00:00:00

  • Autoregulation of the rat prolactin gene in lactotrophs.

    abstract：:The autoregulation of prolactin (PRL) secretion in the rat has been demonstrated at both the hypothalamus and the pituitary levels. Studies on the direct negative feedback effect of PRL in the lactotrophs have concentrated on the acute effect on PRL secretion which does not involve change in PRL synthesis. In this stu...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00178-1

    authors： Devost D,Boutin JM

    更新日期：1999-12-20 00:00:00

  • New perspectives in the function of pituitary folliculo-stellate cells.

    abstract：:Classical morphological studies of the folliculo-stellate (FS) cells of the anterior pituitary have suggested that these cells play roles as supporting cells, in metabolism and in macromolecular transport. Over the last 10 years the details of their activity in both trophic and catabolic processes has been clarified, ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/0303-7207(90)90244-3

    authors： Allaerts W,Carmeliet P,Denef C

    更新日期：1990-06-18 00:00:00

  • Involvement of the protein kinase C pathway in thyrotropin-induced STAT3 activation in FRTL-5 thyroid cells.

    abstract：:The binding of thyrotropin (TSH) to the TSH receptor (TSHR) activates two signaling pathways: the cAMP-protein kinase A (PKA) and the protein kinase C (PKC) systems. We have recently demonstrated that TSH activates the Janus kinases (JAK)/signal transducer and activator of transcription (STAT) pathway via TSHR. This s...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00185-5

    authors： Park YJ,Park ES,Kim MS,Kim TY,Lee HS,Lee S,Jang IS,Shong M,Park DJ,Cho BY

    更新日期：2002-08-30 00:00:00

  • Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.

    abstract：:In the characterization of newly identified proteins, subcellular localization studies can provide important hints to the proteins' metabolic functions. Depending on the biochemical task of an enzyme, certain subcellular environmental conditions as pH or availability of cofactors and substrates have to be fulfilled. C...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2008.07.022

    authors： Keller B,Meier M,Adamski J

    更新日期：2009-03-25 00:00:00

  • Thyroid hormone regulates expression of the thyrotropin beta-subunit gene from both transcription start sites in the mouse and rat.

    abstract：:Thyroid hormones suppress transcription of the gene for the beta-subunit of thyrotropin (TSH beta). Since the TSH beta gene in both the mouse and the rat contains two start sites of transcription in exon 1, we have investigated whether expression of the gene from each start site is differentially regulated by thyroid ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90024-3

    authors： Gurr JA,Januszeski MM,Tidikis IM,Norcross JJ,Kourides IA

    更新日期：1990-07-09 00:00:00

  • Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis.

    abstract：:Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.06.010

    authors： Valéra MC,Noirrit-Esclassan E,Dupuis M,Fontaine C,Lenfant F,Briaux A,Cabou C,Garcia C,Lairez O,Foidart JM,Payrastre B,Arnal JF

    更新日期：2018-12-05 00:00:00

  • Androgen regulation of specific mRNAs, endoplasmic reticulum and Golgi-system.

    abstract：:The seminal vesicles of male rat secrete tissue-specific proteins under androgenic control. The effects of testosterone on the rough endoplasmic reticulum (RER) and Golgi-system of this tissue have been quantified using specific antibodies. Castration was followed within 2 weeks by a 10-fold reduction in RER-specific ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90124-2

    authors： Fawell SE,Higgins SJ

    更新日期：1984-08-01 00:00:00

  • The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.

    abstract：:The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.08.004

    authors： Marotta P,Amendola E,Scarfò M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

    更新日期：2014-10-01 00:00:00

  • Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice.

    abstract：:During normal early pregnancy circulating monocytes are recruited to the maternal-placental interface where they differentiate to macrophages expressing different functional phenotypes for the maintenance of tissue homeostasis. Pregnancy in the nonobese diabetic (NOD) mouse model presents some pathological features in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.11.035

    authors： Larocca L,Hauk V,Calafat M,Roca V,Fraccaroli L,Franchi A,Ramhorst R,Leirós CP

    更新日期：2011-02-20 00:00:00

  • An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.

    abstract：:The antiestrogen tamoxifen has been successfully used to control estrogen receptor (ER) and progesterone receptor positive breast cancer. However, the development of antiestrogen resistance is frequently observed in patients following long term treatment. We have studied the development of antiestrogen resistance in v...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90104-e

    authors： Jiang SY,Wolf DM,Yingling JM,Chang C,Jordan VC

    更新日期：1992-12-01 00:00:00

  • Expression of functional luteinising hormone receptor and its messenger ribonucleic acid in bovine cervix: luteinising hormone augmentation of intracellular cyclic AMP, phosphate inositol and cyclooxygenase.

    abstract：:The effect of luteinising hormone (LH) on bovine cervical tissues from three phases of the estrous cycle was studied. It was found that in the luteal phase cervix contained an LH receptor mRNA transcript and the 93 kDa LH receptor protein. Incubation of cervical minces from luteal phase with LH significantly increased...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00071-4

    authors： Mizrachi D,Shemesh M

    更新日期：1999-11-25 00:00:00

  • Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.

    abstract：:Isolated islets were either studied immediately after isolation (fresh; F), or were cultured for 6 days at 11 mM glucose (desensitized; D), or were incubated for 2 h at 5.5 mM glucose following D (recovered; R). Glucose-stimulated insulin secretion in D islets was reduced compared with F and R islets. In the presence ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03606-8

    authors： Laychock SG

    更新日期：1995-08-30 00:00:00

  • In vitro testing of new somatostatin analogs on pituitary tumor cells.

    abstract：:Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and, indeed, it has been demonstrated that SRIF and its analogs can inhibit pituitary tumor hormone secretion and control neoplastic bulk. Several in vitro studies have contributed to the current knowledge of the mechanisms by which SR...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2007.12.010

    authors： Zatelli MC,Ambrosio MR,Bondanelli M,degli Uberti EC

    更新日期：2008-05-14 00:00:00

  • Characterization and regulation of prolactin receptors in MA-10 Leydig cells.

    abstract：:The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. Two forms of PRL-R, a high and a low molecular weight form, were revealed by studies of covalent crosslinkin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(98)00134-8

    authors： Weiss-Messer E,Ber R,Amit T,Barkey RJ

    更新日期：1998-08-25 00:00:00

  • A quantitative electron microscope autoradiographic study on [3H]prostaglandin E1 and F2 alpha internalization in bovine luteal slices.

    abstract：:Very few silver grains were seen on the luteal cell surface and none intracellularly after incubation for 2 h at 4 degrees C with 10 nM [3H]prostaglandin (PG) E1 or [3H]PGF2 alpha. However, incubation at 22 degrees C or 38 degrees C for 2 h resulted in association of numerous grains on the luteal cell surface as well ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90110-2

    authors： Chegini N,Rao CV,Cobbs G

    更新日期：1984-12-01 00:00:00

  • Point mutations abolish 11 beta-hydroxysteroid dehydrogenase type II activity in three families with the congenital syndrome of apparent mineralocorticoid excess.

    abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol into mineralocorticoid receptor inactive cortisone, thus preventing occupation of the non-selective mineralocorticoid receptor by glucocorticoids in the kidney. Mutations generating inactive enzymes have been described in the HSD1...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03787-2

    authors： Ferrari P,Obeyesekere VR,Li K,Wilson RC,New MI,Funder JW,Krozowski ZS

    更新日期：1996-05-17 00:00:00