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Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.

Abstract：

:Ultraviolet radiation B stimulates both the production of vitamin D3 in the skin and the activation of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central HPA. Since the role of vitamin D3 in the regulation of the HPA is largely unknown, we investigated the impact of 1,25(OH)2D3 and its noncalcemic analogs, 20(OH)D3 and 21(OH)pD, on the expression of the local HPA in human epidermal keratinocytes. The noncalcemic analogs showed similar efficacy to 1,25(OH)2D3 in stimulating the expression of neuropeptides, CRF, urocortins and POMC, and their receptors, CRFR1, CRFR2, MC1R, MC2R, MC3R and MC4R. Interestingly, unlike other secosteroids, the activity of 21(OH)pD did not correlate with induction of differentiation, suggesting a separate but overlapping mechanism of action. Thus, biologically active forms of vitamin D can regulate different elements of the local equivalent of the HPA with implications for the systemic HPA.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Wierzbicka JM,Żmijewski MA,Piotrowska A,Nedoszytko B,Lange M,Tuckey RC,Slominski AT

doi

10.1016/j.mce.2016.08.006

subject

Has Abstract

pub_date

2016-12-05 00:00:00

pages

312-322

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(16)30296-9

journal_volume

437

pub_type

杂志文章

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