Abstract:
:There are multiple systems for cellular cholesterol delivery for steroidogenesis, including uptake of lipoprotein-derived cholesterol via LDL receptor mediated endocytic pathways and SR-BI mediated "selective" pathways, as well as from endogenous cholesterol synthesis and the mobilization of stored cholesteryl esters. The vast majority of lipoprotein-derived cholesterol utilized for murine adrenal steroidogenesis is obtained via SR-BI mediated "selective" uptake of cholesteryl esters. Hormone-sensitive lipase (HSL) is responsible for neutral cholesteryl ester hydrolase activity in the adrenal and is critical for hydrolyzing stored cholesteryl esters, as well as cholesteryl esters that are selectively delivered from lipoproteins via SR-BI. Marked defects in steroid production are observed in adrenal cells from HSL knockout mice, due to an inability to process and utilize cholesteryl esters selectively derived from lipoproteins. Although the LDL receptor is responsible for receptor-mediated endocytic delivery of cholesteryl esters, adrenal steroid hormone production is normal in mice lacking LDL receptors.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Kraemer FBdoi
10.1016/j.mce.2006.12.001subject
Has Abstractpub_date
2007-02-01 00:00:00pages
42-5eissn
0303-7207issn
1872-8057pii
S0303-7207(06)00556-9journal_volume
265-266pub_type
杂志文章,评审abstract::Activating mutations in the follicle-stimulating hormone (FSH) receptor (FSHR) gene are rarely detected due to the absence of a clearly defined phenotype, particularly in men. We here report the biochemical features of a novel mutation in the first extracellular loop of the FSHR. The mutation (N431I) was detected in a...
journal_title:Molecular and cellular endocrinology
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更新日期:2012-11-25 00:00:00
abstract::Using a combination of in vitro assays we have evaluated whether DDT metabolites can interact with the progesterone receptor pathway in yeast expressing human progesterone receptor (hPR) and in T47D human breast cancer cells which express endogenous hPR. In transactivation assays using both yeast and T47D cells, o,p'-...
journal_title:Molecular and cellular endocrinology
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doi:10.1016/s0303-7207(96)04041-5
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abstract::Subjects with androgen insensitivity syndromes (AIS) are characterized by a 46, XY karyotype, presence of testes, normal or elevated androgen levels in blood, and impairment of the usual response to androgens associated with various aberrations of male differentiation and virilization ranging from slightly undervirili...
journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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更新日期:2005-10-20 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(79)90057-1
更新日期:1979-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2015.09.015
更新日期:2016-01-05 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0303-7207(93)90077-w
更新日期:1993-03-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.mce.2009.09.020
更新日期:2010-03-05 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(87)90125-0
更新日期:1987-05-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2010.04.019
更新日期:2010-08-30 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2003.11.030
更新日期:2004-04-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2015.08.008
更新日期:2015-11-05 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:1998-05-25 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.mce.2012.11.019
更新日期:2013-05-22 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2012.05.013
更新日期:2012-10-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2004.03.009
更新日期:2004-05-31 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2007.08.009
更新日期:2007-12-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:2001-12-20 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2006.11.002
更新日期:2007-01-29 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/s0303-7207(96)03977-9
更新日期:1997-02-07 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/s0303-7207(98)00110-5
更新日期:1998-07-25 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(91)90032-n
更新日期:1991-12-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(76)90051-4
更新日期:1976-05-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(92)90131-o
更新日期:1992-05-01 00:00:00