Characterization of the transcription start site of the ACTH receptor gene: presence of an intronic sequence in the 5'-flanking region.

abstract：:A pair of glands (Y-organs) in crustaceans synthesize and secrete ecdysteroid hormones; the obligate precursor for synthesis is circulating cholesterol. Ecdysteroid output by the Y-organs is regulated negatively by an eyestalk neurosecretory peptide, molt-inhibiting hormone (MIH). The question was addressed, does MIH ...

journal_title：Molecular and cellular endocrinology

authors： Spaziani E,Wang WL

更新日期：1993-09-01 00:00:00

abstract：:This study investigated the effects of SOD2 (MnSOD)-deficiency-induced excessive oxidative stress on ovarian steroidogenesis in vivo and isolated and cultured granulosa cells using WT and Sod2+/- mice. Basal and 48 h eCG-stimulated plasma progesterone levels were decreased ~50% in female Sod2+/- mice, whereas plasma p...

journal_title：Molecular and cellular endocrinology

authors： Zaidi SK,Shen WJ,Cortez Y,Bittner S,Bittner A,Arshad S,Huang TT,Kraemer FB,Azhar S

更新日期：2021-01-01 00:00:00

abstract：:We used murine Ba/F3 cells transfected with human growth hormone receptor (hGHR) cDNA to investigate the regulatory mechanisms of human growth hormone-binding protein (hGH-BP) release. The extracellular domain of hGHRs were cleaved and released as hGH-BPs (a soluble form of hGHR). The hGH-BP release was enhanced by ph...

journal_title：Molecular and cellular endocrinology

authors： Takagi K,Saito Y,Sawada J

更新日期：2001-09-01 00:00:00

abstract：:The requirement for caspases (ICE-like proteases) were investigated in mediating apoptosis of WEHI7.2 mouse lymphoma cells in response to two death inducers with different mechanisms of action, the glucocorticoid hormone dexamethasone (DX) and the calcium-ATPase inhibitor thapsigargin (TG). Apoptosis induction by thes...

journal_title：Molecular and cellular endocrinology

authors： McColl KS,He H,Zhong H,Whitacre CM,Berger NA,Distelhorst CW

更新日期：1998-04-30 00:00:00

abstract：:The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

journal_title：Molecular and cellular endocrinology

authors： Rudolph AE,Blasi ER,Delyani JA

更新日期：2000-07-25 00:00:00

abstract：:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to m...

journal_title：Molecular and cellular endocrinology

authors： Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

更新日期：2011-12-05 00:00:00

abstract：:The NIH has recently highlighted the importance of sexual dimorphisms and has mandated inclusion of both sexes in clinical trials and basic research. In this review we highlight new and novel ways sex hormones influence body adiposity and the metabolic syndrome. Understanding how and why metabolic processes differ by ...

journal_title：Molecular and cellular endocrinology

authors： Palmer BF,Clegg DJ

更新日期：2015-02-15 00:00:00

abstract：:The binding of vasopressin, angiotensin II and prazosin (alpha 1-adrenergic antagonist) to purified heavy (GH) and (intermediate + light) (GI + L) rat liver Golgi fractions was studied. The three types of ligands showed a saturable and specific binding in Golgi fractions; the maximal specific binding of [3H]vasopressi...

journal_title：Molecular and cellular endocrinology

authors： Cantau B,Guillemette G,Chicot D,Devilliers G

更新日期：1987-05-01 00:00:00

abstract：:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in...

journal_title：Molecular and cellular endocrinology

authors： Wang CY,Chen WY,Lai PY,Chung BC

更新日期：2013-05-22 00:00:00

abstract：:Using primary cultures of porcine Sertoli cells as a model, the effects of ovine prolactin (oPRL) on Sertoli cell function were investigated through FSH binding. PRL treatment (0.3-5 ng/ml) induced a dose-dependent increase (ED50 = 5.10(-11) M) of 125I-FSH binding to Sertoli cells to a maximal stimulation (about 2.5-f...

journal_title：Molecular and cellular endocrinology

authors： Guillaumot P,Tabone E,Benahmed M

更新日期：1996-09-18 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:The status of the neuroendocrine reproductive axis differs dramatically during various stages of development, and also differs in several critical ways between the sexes, including its earlier pubertal activation in females than males and the presence of neural circuitry that generates preovulatory hormone surges in f...

journal_title：Molecular and cellular endocrinology

authors： Kauffman AS

更新日期：2010-08-05 00:00:00

abstract：:Procedures have been developed which provide simple means of determining binding constants of steroid receptors for glucocorticoids in mouse lymphoid cell lines and of characterizing the interaction of the steroid--receptor complex with the nucleus. An average of 70% of the steroid--receptor complexes is found associa...

journal_title：Molecular and cellular endocrinology

authors： Pfahl M,Sandros T,Bourgeois S

更新日期：1978-04-01 00:00:00

abstract：:A rapid and sensitive assay of iodothyronine-5'-monodeiodinase (5'-D) was developed using Sephadex column chromatography for separation of substrate 125I-rT3 from the product free 125I-. The distribution of 5'-D activity on rat kidney cortex cell membranes was examined in isopycnic zonal centrifugation experiments usi...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P,Jørgensen PL

更新日期：1988-03-01 00:00:00

abstract：:Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung cancer line (BEN cells). Northern analysis demonstrated that calcitonin caused a rapid 4.5-fold elevation in PTHrP mRNA. Transient transfection of a construct containing 1119 base pairs of the ...

journal_title：Molecular and cellular endocrinology

authors： Chilco PJ,Gerardi JM,Kaczmarczyk SJ,Chu S,Leopold V,Zajac JD

更新日期：1993-07-01 00:00:00

abstract：:Stimulation of insulin secretion is accompanied by changes in the phosphorylation state of several islet polypeptides. Protein (de)phosphorylation is mediated by the action of protein kinases and phosphoprotein phosphatases. In this study we have investigated expression of phospho-serine/threonine phosphatases (PPs) i...

journal_title：Molecular and cellular endocrinology

authors： Murphy LI,Jones PM

更新日期：1996-03-25 00:00:00

abstract：:The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo impl...

journal_title：Molecular and cellular endocrinology

authors： Grasso E,Gori S,Paparini D,Soczewski E,Fernández L,Gallino L,Salamone G,Martinez G,Irigoyen M,Ruhlmann C,Pérez Leirós C,Ramhorst R

更新日期：2018-01-15 00:00:00

abstract：:Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the...

journal_title：Molecular and cellular endocrinology

authors： Valéra MC,Noirrit-Esclassan E,Dupuis M,Fontaine C,Lenfant F,Briaux A,Cabou C,Garcia C,Lairez O,Foidart JM,Payrastre B,Arnal JF

更新日期：2018-12-05 00:00:00

abstract：:In previous studies, we found that endometriotic stromal cells lose the ability to regulate cell survival signaling in endometriotic epithelial cells. Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved. We found that ecto...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Xue J,Li M,Zhao X,Wei D,Li C

更新日期：2015-09-15 00:00:00

abstract：:Calcium salts were found to replace ACTH in inducing steroidogenesis in isolated adrenocortical cells from rats. This Ca-specific stimulation occurred when the cation was presented to the cells in the presence of phosphate and carbonate as a counter-ions under conditions which favoured the formation of colloidal calci...

journal_title：Molecular and cellular endocrinology

authors： Neher R,Milani A

更新日期：1978-01-01 00:00:00

abstract：:The number of adipocyte progenitors is determined early in foetal and neonatal development in a process which may be altered by gender and excess nutrient intake, and which in turn determines fat mass in adulthood and the risk of developing obesity. Here we investigate the hypothesis that excess nutrients, in this cas...

journal_title：Molecular and cellular endocrinology

authors： Petrighi Polidori G,Lomax MA,Docherty K

更新日期：2012-09-25 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase type 1 (17-HSD type 1) is a steroidogenic enzyme catalyzing reversible interconversion of estradiol and estrone. 17-HSD type 1 is actively expressed in human placenta. We characterized 17-HSD type 1 expression and its regulation by basic fibroblast growth factor (bFGF) in JAR, JEG-...

journal_title：Molecular and cellular endocrinology

authors： Lewintre EJ,Orava M,Peltoketo H,Vihko R

更新日期：1994-08-01 00:00:00

abstract：:Primary cultures of ovine thyroid cells were induced to differentiate by addition of thyrotropin (TSH). This was demonstrated as an accumulation of 2 thyroid-specific proteins, thyroglobulin and thyroid peroxidase, using immunofluorescent staining methods and immunoprecipitation of biosynthetically labeled cultures. A...

journal_title：Molecular and cellular endocrinology

authors： Errick JE,Eggo MC,Burrow GN

更新日期：1985-11-01 00:00:00

abstract：:Apolipoprotein E (APOE) deficient mice exhibit unexplained hypercorticosteronemia. Given that APOE is also produced locally within the adrenals, we evaluated the effect of adrenal-specific APOE deficiency on the glucocorticoid function. Hereto, one adrenal containing or lacking APOE was transplanted into adrenalectomi...

journal_title：Molecular and cellular endocrinology

authors： van der Sluis RJ,Depuydt MAC,Verwilligen RAF,Hoekstra M,Van Eck M

更新日期：2019-06-15 00:00:00

abstract：:In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between sever...

journal_title：Molecular and cellular endocrinology

authors： Dacheux JL,Belleannée C,Jones R,Labas V,Belghazi M,Guyonnet B,Druart X,Gatti JL,Dacheux F

更新日期：2009-07-10 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor PAC1-R (PACAP type 1 receptor) are transiently expressed in granulosa cells (GCs) of mouse preovulatory follicles and affect several parameters associated with the ovulatory process. We investigated the expression of PACAP and its receptors in...

journal_title：Molecular and cellular endocrinology

authors： Barberi M,Di Paolo V,Latini S,Guglielmo MC,Cecconi S,Canipari R

更新日期：2013-08-15 00:00:00

abstract：:The identification of XY females carrying a duplication of a region of the X chromosome (Xp21) led to the hypothesis that a double dose of a gene in the duplicated region causes sex reversal (DSS; dosage sensitive sex reversal). A gene isolated from this region, named DAX-1 (DSS-AHC critical region on the X), encodes ...

journal_title：Molecular and cellular endocrinology

authors： Parma P,Pailhoux E,Puissant C,Cotinot C

更新日期：1997-11-30 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00

abstract：:The regulation of human implantation is not fully understood. hCG as one of the earliest embryonal signals may be a major regulator in the parakrine embryo-endometrial communication. The expression of full-length hCG/LH-receptor mRNA could be demonstrated in human endometrium throughout the follicular and secretory ph...

journal_title：Molecular and cellular endocrinology

authors： Licht P,Fluhr H,Neuwinger J,Wallwiener D,Wildt L

更新日期：2007-04-15 00:00:00

abstract：:Berberine has been shown to have insulin-sensitizing effect, but the molecular mechanism underlying remains elusive. In this work, we investigated the effect of berberine on insulin-induced signal transduction and glucose uptake in both insulin-sensitive and insulin-resistant rat skeletal muscle cells. Berberine incre...

journal_title：Molecular and cellular endocrinology

authors： Liu LZ,Cheung SC,Lan LL,Ho SK,Xu HX,Chan JC,Tong PC

更新日期：2010-04-12 00:00:00