Porcine Dax-1 gene: isolation and expression during gonadal development.

abstract：:The Steroidogenic acute regulatory protein (StAR) directs mitochondrial cholesterol uptake through a C-terminal cholesterol binding domain (CBD) and a 62 amino acid N-terminal regulatory domain (NTD) that contains an import sequence and conserved sites for inner membrane metalloproteases. Deletion of the NTD prevents ...

journal_title：Molecular and cellular endocrinology

authors： Lee J,Yamazaki T,Dong H,Jefcoate C

更新日期：2017-02-05 00:00:00

abstract：:We have previously shown that the tyrosine kinase receptor Flk-1 and its ligand, vascular endothelial growth factor (VEGF), may play a role in the development of fetal rat islet-like structures in vitro, possibly by stimulating the maturation of endocrine precursor cells in the pancreatic ductal epithelium. In order t...

journal_title：Molecular and cellular endocrinology

authors： Oberg-Welsh C,Sandler S,Andersson A,Welsh M

更新日期：1997-02-07 00:00:00

abstract：:Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP...

journal_title：Molecular and cellular endocrinology

authors： Flajollet S,Lefebvre B,Cudejko C,Staels B,Lefebvre P

更新日期：2007-05-30 00:00:00

abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

journal_title：Molecular and cellular endocrinology

authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

更新日期：2003-04-28 00:00:00

abstract：:For investigation of the mechanism and pathogenesis of Graves' disease, availability of a large amount of functional human thyrotropin receptor (TSHR) capable of recognition by Graves' autoantibodies is essential. Many attempts have been made to produce the extracellular domain of TSH receptor (TSHRE) in a baculovirus...

journal_title：Molecular and cellular endocrinology

authors： Park JY,Lee J,Cho BY,Chae CB

更新日期：1999-01-25 00:00:00

abstract：:The time- and dose-dependent effects of bovine activin A and bovine follicle stimulating hormone (FSH) suppressing protein (FSP) or follistatin on basal and FSH-induced steroidogenesis and inhibin production were studied in granulosa cells from immature, diethylstilbestrol (DES)-treated rats. In the presence of rat FS...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK,Robertson DM

更新日期：1990-02-12 00:00:00

abstract：:Transgenic mice carrying a fused gene of the 294-base upstream and 68-base leader sequences of a rat calmodulin gene, CaMII, and beta-galactosidase gene were made. Only spermatocytes expressed the transgene mRNA in the testes of four independent transgenic lines. The localization of transgene mRNA was consistent with ...

journal_title：Molecular and cellular endocrinology

authors： Ikeshima H,Shimoda K,Matsuo K,Hata J,Maejima K,Takano T

更新日期：1994-02-01 00:00:00

abstract：:Successful embryo implantation is a complex and highly regulated process involving precise synchronization between the fetal-derived trophoblast cells and maternal uterine luminal epithelium. Multiple endocrine-driven factors are important for controlling the timely receptivity of the uterus, and this complexity under...

journal_title：Molecular and cellular endocrinology

authors： Quinn KE,Matson BC,Wetendorf M,Caron KM

更新日期：2020-02-05 00:00:00

abstract：:The luteinizing hormone receptor (LHR), one of the three glycoprotein hormone receptors, is necessary for critical reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation, and male sex differentiation. Moreover, it has been postulated to contribute to certain neoplasms, particularly ...

journal_title：Molecular and cellular endocrinology

authors： Puett D,Angelova K,da Costa MR,Warrenfeltz SW,Fanelli F

更新日期：2010-11-25 00:00:00

abstract：:Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue ...

journal_title：Molecular and cellular endocrinology

authors： Lee P,Greenfield JR

更新日期：2015-12-15 00:00:00

abstract：:The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes. Important in this relationship is the strong correlation between hyperinsulinemia and low levels of albuminuria (e.g. microalbuminuria). Recent work highl...

journal_title：Molecular and cellular endocrinology

authors： Nistala R,Whaley-Connell A

更新日期：2013-09-25 00:00:00

abstract：:The higher prevalence of thyroid disease in women suggests that estrogen (E2) might be involved in the pathophysiology of thyroid dysfunction. To approach the question of the effect of stromal cells in the modulation of thyroid epithelial cells activity, we established and characterized a homogeneous stromal cell popu...

journal_title：Molecular and cellular endocrinology

authors： Gantus MA,Alves LM,Stipursky J,Souza EC,Teodoro AJ,Alves TR,Carvalho DP,Martinez AM,Gomes FC,Nasciutti LE

更新日期：2011-04-30 00:00:00

abstract：:As deduced on the basis of cloning experiments, the putative extracellular domain of pituitary glycoprotein hormone (lutropin (LH), thyrotropin (TSH), and FSH) receptors (rec) is sufficiently large to suggest involvement in hormone binding. Comparison of the amino acid sequences of the extracellular domains of the gly...

journal_title：Molecular and cellular endocrinology

authors： Dattatreyamurty B,Reichert LE Jr

更新日期：1992-09-01 00:00:00

abstract：:The interaction of tamoxifen (ICI 46,474), a synthetic antiestrogen, with uterine cytosol proteins of immature calf and rat has been studied directly using the tritiated compound labeled with a high specific activity. The binding complexes were measured by the dextrancoated charcoal, protamine sulfate and hydroxyapati...

journal_title：Molecular and cellular endocrinology

authors： Capony F,Rochefort H

更新日期：1978-07-01 00:00:00

abstract：:Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA cod...

journal_title：Molecular and cellular endocrinology

authors： Baertschi AJ

更新日期：1994-05-01 00:00:00

abstract：:Considering that post-menopausal women and ovariectomized rodents develop obesity associated with increased visceral fat, this study was developed to investigate if liraglutide, a glucagon-like peptide 1 (GLP1) analogue, could improve the metabolism of estrogen (E2) deficient females. Wistar rats were ovariectomized (...

journal_title：Molecular and cellular endocrinology

authors： Model JFA,Lima MV,Ohlweiler R,Lopes Vogt É,Rocha DS,Souza SK,Türck P,Araújo ASDR,Vinagre AS

更新日期：2021-01-11 00:00:00

abstract：:Melatonin can be synthesized and secreted not only by the pineal gland but also by many extra-pineal tissues. It has been shown that many ovarian functions are regulated by melatonin locally. Ovarian hyperstimulation syndrome (OHSS) is a serious complication during ovulation induction of the in vitro fertilization tre...

journal_title：Molecular and cellular endocrinology

authors： Li Y,Fang L,Zhang R,Wang S,Li Y,Yan Y,Yu Y,Cheng JC,Sun YP

更新日期：2020-12-01 00:00:00

abstract：:The effect of insulin on human red blood cells was investigated, both on intact cells and on isolated plasma membranes, testing the responsiveness of membrane-bound enzymes--such as (Na+-K+)-ATPase and 5'-nucleotidase--as well as the ouabain binding and ionic fluxes. It appears that insulin stimulates Na-pumping mecha...

journal_title：Molecular and cellular endocrinology

authors： Baldini P,Incerpi S,Pascale E,Rinaldi C,Verna R,Luly P

更新日期：1986-07-01 00:00:00

abstract：:Corticotropin (ACTH) regulates glucocorticoid production through specific receptors on the adrenal cortex. Analysis of the ACTH receptor mRNA in human adrenal has revealed the presence of five transcripts ranging from 1.8 to 11 kilobases (kb). Characterization of the 5'-untranslated regions (UTRs) of the ACTH receptor...

journal_title：Molecular and cellular endocrinology

authors： Naville D,Barjhoux L,Jaillard C,Lebrethon MC,Saez JM,Bégeot M

更新日期：1994-12-01 00:00:00

abstract：:People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell developme...

journal_title：Molecular and cellular endocrinology

authors： Chen SC,Brooks R,Houskeeper J,Bremner SK,Dunlop J,Viollet B,Logan PJ,Salt IP,Ahmed SF,Yarwood SJ

更新日期：2017-01-15 00:00:00

abstract：:Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of collagenase in uterine smooth muscle cells, a normal, non-inflammatory process that ...

journal_title：Molecular and cellular endocrinology

authors： Huang TT,Vinci JM,Lan L,Jeffrey JJ,Wilcox BD

更新日期：1999-06-25 00:00:00

abstract：:Transcription of the glycoprotein hormone alpha-subunit gene in the pituitary is governed by different promoter elements in thyrotropes and gonadotropes. We recently identified an upstream enhancer that directs a high level of cell type specific expression in transgenic mice and stimulates proximal promoter activity i...

journal_title：Molecular and cellular endocrinology

authors： Wood WM,Dowding JM,Sarapura VD,McDermott MT,Gordon DF,Ridgway EC

更新日期：1998-07-25 00:00:00

abstract：:The chum salmon insulin-like growth factor II (IGF-II) gene is highly expressed in liver tissue. In this study we demonstrate that two transcription factors, Sp1 and C/EBPbeta, are involved in the enhanced expression of the salmon IGF-II gene. The presence of the fish homolog for C/EBPbeta in salmon liver RNA was conf...

journal_title：Molecular and cellular endocrinology

authors： Palamarchuk AY,Kavsan VM,Sussenbach JS,Holthuizen PE

更新日期：2001-02-14 00:00:00

abstract：:We recently cloned and sequenced two kilobases of the upstream flanking region of the mouse tissue transglutaminase gene. Transfection experiments showed that this region of the transglutaminase flanking sequence was sufficient to mediate a 4-fold induction in reporter gene expression by retinoic acid. The goal of the...

journal_title：Molecular and cellular endocrinology

authors： Yan ZH,Noonan S,Nagy L,Davies PJ,Stein JP

更新日期：1996-07-01 00:00:00

abstract：:The high mobility group AT-hook (HMGA) proteins, a family of DNA architectural factors, are highly expressed during embryogenesis and play a crucial role in several different biological processes, as well as in tumorigenesis of a wide range of tissues, including pituitary. Indeed, HMGA2 has been found rearranged and a...

journal_title：Molecular and cellular endocrinology

authors： Fedele M,Palmieri D,Fusco A

更新日期：2010-09-15 00:00:00

abstract：:The role of cannabinoid receptor I (CBR-1) in the induction of decidualization was examined using decidual fibroblasts and human endometrial stromal cells as model systems. Decidual fibroblasts decidualized in vitro for 3 and 6 days in the presence of the CBR-1 agonist R(+)-WIN 55,212-2 mesylate (WIN, 0.1-10 microM) e...

journal_title：Molecular and cellular endocrinology

authors： Moghadam KK,Kessler CA,Schroeder JK,Buckley AR,Brar AK,Handwerger S

更新日期：2005-01-14 00:00:00

abstract：:P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450s and mutations in POR cause several metabolic disorders. We have modeled the structure of human P450 oxidoreductase by in silico amino acid replacements in the rat POR crystal structure. The rat POR has 94% homology with human POR ...

journal_title：Molecular and cellular endocrinology

authors： Flück CE,Mullis PE,Pandey AV

更新日期：2009-12-10 00:00:00

abstract：OBJECTIVE:Significant attempts are being made to generate multifunctional, hybrid or peptide combinations as novel therapeutic strategies for type 2 diabetes, however this presents key challenges including design and pharmaceutical development. In this study, we evaluated metabolic properties of oral nutritional supple...

journal_title：Molecular and cellular endocrinology

authors： Pathak NM,Millar PJB,Pathak V,Flatt PR,Gault VA

更新日期：2018-01-15 00:00:00

abstract：:The first exon of the human androgen receptor (AR) contains a translated CAG (poly-glutamine) repeat. The repeat length is polymorphic in the normal population ranging from 8 to 35 repeats. Expansions to over 40 repeats lead to spinal bulbar muscular atrophy (SBMA), a late onset neurodegenerative disease. The repeat i...

journal_title：Molecular and cellular endocrinology

authors： Ferro P,Catalano MG,Dell'Eva R,Fortunati N,Pfeffer U

更新日期：2002-07-31 00:00:00

abstract：:Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse subma...

journal_title：Molecular and cellular endocrinology

authors： Ludwig G,Ganten D,Murakami K,Fasching U,Hackenthal E

更新日期：1987-04-01 00:00:00