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Resistance to insulin and kidney disease in the cardiorenal metabolic syndrome; role for angiotensin II.

Abstract：

:The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes. Important in this relationship is the strong correlation between hyperinsulinemia and low levels of albuminuria (e.g. microalbuminuria). Recent work highlight mechanisms for glomerular/tubulointerstitial injury with excess insulin and emerging evidence identifies a unique role for insulin metabolic signaling and altered handling of salt reabsorption at the level of the proximal tubule. Evidence is also emerging for the role of insulin signaling in the glomerulus both epithelial and endothelial. Central to the mechanism of injury is inappropriate activation of the RAAS.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Nistala R,Whaley-Connell A

doi

10.1016/j.mce.2013.02.005

subject

Has Abstract

pub_date

2013-09-25 00:00:00

pages

53-8

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(13)00063-4

journal_volume

378

pub_type

杂志文章,评审

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