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Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.

Abstract：

:Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension. Despite significant progress in the diagnosis and management of PA, until recently the molecular mechanisms leading to inappropriate aldosterone production were largely unknown. The introduction of next-generation sequencing has had a profound impact on the field of human genetics and has given new insight in the molecular determinants that lead to both sporadic and familial forms of PA. Here we review the recent progress toward understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Monticone S,Else T,Mulatero P,Williams TA,Rainey WE

doi

10.1016/j.mce.2014.09.015

subject

Has Abstract

pub_date

2015-01-05 00:00:00

pages

311-20

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00295-0

journal_volume

399

pub_type

杂志文章,评审

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