Abstract：
:Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension. Despite significant progress in the diagnosis and management of PA, until recently the molecular mechanisms leading to inappropriate aldosterone production were largely unknown. The introduction of next-generation sequencing has had a profound impact on the field of human genetics and has given new insight in the molecular determinants that lead to both sporadic and familial forms of PA. Here we review the recent progress toward understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Monticone S,Else T,Mulatero P,Williams TA,Rainey WEdoi
10.1016/j.mce.2014.09.015subject
Has Abstractpub_date
2015-01-05 00:00:00pages
311-20eissn
0303-7207issn
1872-8057pii
S0303-7207(14)00295-0journal_volume
399pub_type
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