Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.

abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

journal_title：Molecular and cellular endocrinology

authors： Patel KV,Schrey MP

更新日期：1992-06-01 00:00:00

abstract：:Glucocorticoids play a primary role in the maturation of fetal organs and may contribute to the onset of labour. Glucocorticoid activity depends on the 11β-hydroxysteroid dehydrogenase family (11β-HSDs), catalysing the interconversion between "active" cortisol into inactive cortisone. No definitive study exists on 11β...

journal_title：Molecular and cellular endocrinology

authors： Damiani F,Makieva S,Rinaldi SF,Hua L,Marcolongo P,Petraglia F,Norman JE

更新日期：2017-05-15 00:00:00

abstract：:Prenatal testosterone (T)-treated female sheep exhibit an enhanced inflammatory and oxidative stress state in the visceral adipose tissue (VAT) but not in the subcutaneous (SAT), while surprisingly maintaining insulin sensitivity in both depots. In adult sheep, adipose tissue is predominantly composed of white adipocy...

journal_title：Molecular and cellular endocrinology

authors： Puttabyatappa M,Ciarelli JN,Chatoff AG,Singer K,Padmanabhan V

更新日期：2020-03-01 00:00:00

abstract：:Imprinted gene expression in preimplantation development has been extensively studied in the mouse. Different imprinted genes vary in their time of onset of expression and also in the timing and tissue-specificity of mono-allelic expression. We have surveyed a range of imprinted genes for expression, and mono-allelic ...

journal_title：Molecular and cellular endocrinology

authors： Monk M,Salpekar A

更新日期：2001-10-22 00:00:00

abstract：:The interaction of tamoxifen (ICI 46,474), a synthetic antiestrogen, with uterine cytosol proteins of immature calf and rat has been studied directly using the tritiated compound labeled with a high specific activity. The binding complexes were measured by the dextrancoated charcoal, protamine sulfate and hydroxyapati...

journal_title：Molecular and cellular endocrinology

authors： Capony F,Rochefort H

更新日期：1978-07-01 00:00:00

abstract：:Oncogenic osteomalacia is a condition where renal phosphate wasting occurs causing defective mineralisation, in the presence of a tumor. Cultures of cells were established from a hemangiopericytoma resected from a patient with oncogenic osteomalacia. Conditioned media from the cells inhibited phosphate uptake in oposs...

journal_title：Molecular and cellular endocrinology

authors： Nelson AE,Namkung HJ,Patava J,Wilkinson MR,Chang AC,Reddel RR,Robinson BG,Mason RS

更新日期：1996-11-29 00:00:00

abstract：:125I-glucagon was directly cross-linked to its receptor in isolated adipocyte plasma membranes using a UV irradiation procedure. This investigation resulted in identification of an adipocyte glucagon receptor complex of 62 kDa, present both in white and brown adipose tissues. The specificity of labeling was shown by i...

journal_title：Molecular and cellular endocrinology

authors： Iwanij V,Amos TM,Billington CJ

更新日期：1994-05-01 00:00:00

abstract：:The objective of this work was to identify the natural substrates of cyclic AMP-dependent protein kinase in pituitary cells. Studies were performed using 2 systems: intact pituitary cells stimulated with dibutyryl cyclic AMP (DBC) after preincubation with [gamma-32P]. Phosphorylation of proteins was analyzed by two-di...

journal_title：Molecular and cellular endocrinology

authors： Brattin WJ Jr,Portanova R

更新日期：1981-07-01 00:00:00

abstract：:Aldosterone plays an important role in electrolyte and blood pressure homeostasis. Our studies have focused on the role of aldosterone in essential hypertension. We have shown that plasma aldosterone and ARR are heritable characteristics and that aldosterone concentrations in older subjects are inversely correlated wi...

journal_title：Molecular and cellular endocrinology

authors： Davies E,Mackenzie SM,Freel EM,Alvarez-Madrazo S,Fraser R,Connell JM

更新日期：2009-03-05 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:Berberine has been shown to have insulin-sensitizing effect, but the molecular mechanism underlying remains elusive. In this work, we investigated the effect of berberine on insulin-induced signal transduction and glucose uptake in both insulin-sensitive and insulin-resistant rat skeletal muscle cells. Berberine incre...

journal_title：Molecular and cellular endocrinology

authors： Liu LZ,Cheung SC,Lan LL,Ho SK,Xu HX,Chan JC,Tong PC

更新日期：2010-04-12 00:00:00

abstract：:Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, PC2, CPE and preproNPY protein expression levels were compared among m...

journal_title：Molecular and cellular endocrinology

authors： Tang SS,Zhang JH,Liu HX,Li HZ

更新日期：2009-05-06 00:00:00

abstract：:The major source for dehydroepiandrosterone (DHEA) and its sulphate compound DHEA-S is the inner zone of the adrenal cortex, which is in direct contact to adrenomedullary chromaffin cells. Due to their close proximity, direct interactions of DHEA and DHEA-S with chromaffin cells during adrenal gland development and th...

journal_title：Molecular and cellular endocrinology

authors： Krug AW,Langbein H,Ziegler CG,Bornstein SR,Eisenhofer G,Ehrhart-Bornstein M

更新日期：2009-03-05 00:00:00

abstract：:Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to...

journal_title：Molecular and cellular endocrinology

authors： Purohit A,Woo LW,Potter BV

更新日期：2011-07-04 00:00:00

abstract：:Insulin stimulates rapid tyrosine phosphorylation of the protein Shc, which subsequently binds to Grb2, resulting in the activation of a complex mitogenic signaling network. In this study, we examined the levels of Shc protein, its phosphorylation state and Shc-Grb2 association in liver, muscle and adipose tissue befo...

journal_title：Molecular and cellular endocrinology

authors： Páez-Espinosa EV,Rocha EM,Velloso LA,Boschero AC,Saad MJ

更新日期：1999-10-25 00:00:00

abstract：:Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose i...

journal_title：Molecular and cellular endocrinology

authors： Macklon NS,Fauser BC

更新日期：2002-01-25 00:00:00

abstract：:Dopamine and somatostatin are both involved in the negative control of normal pituitary cells. Dopamine subtype 2 receptor (D2DR) and somatostatin receptor (sst) agonists, mainly directed to sst2, are used in the treatment of pituitary adenomas. Nevertheless, a majority of corticotroph and gonadotroph adenomas and a t...

journal_title：Molecular and cellular endocrinology

authors： Saveanu A,Jaquet P,Brue T,Barlier A

更新日期：2008-05-14 00:00:00

abstract：:The growth of ZR-75-1 cells, a line of human breast cancer cells in culture, is stimulated by oestradiol and inhibited by anti-oestrogens. Changes in growth rate caused by these agents are accompanied by changes in activity of ornithine decarboxylase, a rate-limiting enzyme for polyamine synthesis. Furthermore, the gr...

journal_title：Molecular and cellular endocrinology

authors： Hoggard N,Green CD

更新日期：1986-06-01 00:00:00

abstract：:Over 20 mutations affecting the neurophysin moiety of the vasopressin prohormone, have been identified in families suffering from familial neurohypophysial diabetes insipidus (FNDI). Only one of these, NP87E-->stop, is located outside the central conserved domain implicated in sorting of the vasopressin prohormone. To...

journal_title：Molecular and cellular endocrinology

authors： Nijenhuis M,Zalm R,Burbach JP

更新日期：2000-09-25 00:00:00

abstract：:A Chinese family with autosomal recessive pituitary dwarfism was identified and the proband was evaluated by MRI and hormonal analysis, which revealed pituitary dwarfism with a complete growth hormone deficiency. MRI showed a pituitary gland with a small anterior pituitary of 2.2mm and evidence of hypoplastic pituitar...

journal_title：Molecular and cellular endocrinology

authors： Wang Q,Diao Y,Xu Z,Li X,Luo XP,Xu H,Ouyang P,Liu M,Hu Z,Wang QK,Liu JY

更新日期：2009-12-10 00:00:00

abstract：:Testosterone can be converted into androstenedione (4-dione) by 17β-hydroxysteroid dehydrogenase (HSD) activity likely performed by 17β-HSD type 2. Our objective was to evaluate the rate of testosterone conversion to 4-dione as well as expression and localization of 17β-HSD type 2 in omental (OM) vs. subcutaneous (SC)...

journal_title：Molecular and cellular endocrinology

authors： Fouad Mansour M,Pelletier M,Boulet MM,Mayrand D,Brochu G,Lebel S,Poirier D,Fradette J,Cianflone K,Luu-The V,Tchernof A

更新日期：2015-10-15 00:00:00

abstract：:Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism (CH), a relatively frequent endocrine disease in newborns (1 in 3000-4000 live births). TD is a defect in the organogenesis of the gland resulting in hypoplastic, ectopic or absent-thyroid gland. TD is usually sporadic but mutations in trans...

journal_title：Molecular and cellular endocrinology

authors： Montanelli L,Tonacchera M

更新日期：2010-06-30 00:00:00

abstract：:Mineralocorticoid receptor (MR) signaling is pivotal for numerous physiological processes and implicated in various pathological conditions concerning among others, tight epithelia, central nervous and cardiovascular systems. For decades, the pleiotropic actions of MR have been investigated using animal and cellular m...

journal_title：Molecular and cellular endocrinology

authors： Le Menuet D,Munier M,Campostrini G,Lombès M

更新日期：2012-03-24 00:00:00

abstract：:Protein phosphorylation-dephosphorylation appears to be an essential component in the regulation of many cellular processes by hormones and drugs. This concept has developed primarily from in vitro biochemical studies in which various purified proteins have been phosphorylated and dephosphorylated by distinct protein ...

journal_title：Molecular and cellular endocrinology

authors： Manning DR,DiSalvo J,Stull JT

更新日期：1980-07-01 00:00:00

abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

journal_title：Molecular and cellular endocrinology

authors： Domené S,Domené HM

更新日期：2020-12-01 00:00:00

abstract：:To define the heparin-binding site of follistatin, the reduced and S-carboxymethylated recombinant human follistatin containing 288 amino acids was digested by Staphylococcus aureus V8. The digested product was subjected to sulfate cellufine column chromatography and the adsorbed peptide fragments eluted with a stepwi...

journal_title：Molecular and cellular endocrinology

authors： Inouye S,Ling N,Shimasaki S

更新日期：1992-12-01 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:GLP-1, incretin with insulin-independent antidiabetic properties, is insulinomimetic upon glucose metabolism in extrapancreatic tissues, acting through specific receptors not associated to adenylate cyclase activation. We investigated the role of enzymes mediating insulin actions, in the GLP-1-induced glycogen synthas...

journal_title：Molecular and cellular endocrinology

authors： Redondo A,Trigo MV,Acitores A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2003-06-30 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:Estrogen receptor β (ERβ) and its isoforms have different putative functions and expression patterns in prostate cancer. Current studies on 5'-most exons, 0K and 0N, show that their respective promoters are actively involved in transcription. These data, however, do not explain why ERβ isoforms are differentially expr...

journal_title：Molecular and cellular endocrinology

authors： Lee MT,Ouyang B,Ho SM,Leung YK

更新日期：2013-08-25 00:00:00