Identification and characterization of the glucagon receptor from adipose tissue.

abstract：:A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increas...

journal_title：Molecular and cellular endocrinology

authors： Fujimori C,Ogiwara K,Hagiwara A,Takahashi T

更新日期：2012-10-15 00:00:00

abstract：:Hypothalamic astrocytes secrete TGF-beta and 3 alpha,5 alpha-tetrahydro progesterone (3 alpha,5 alpha-THP) in culture. When the astrocyte-conditioned medium (ACM) was incubated with the hypothalamic cell line GT1-7, it resulted in the secretion of GnRH. Immunoneutralization with TGF-beta antibody or ultra-filteration ...

journal_title：Molecular and cellular endocrinology

authors： Mahesh VB,Dhandapani KM,Brann DW

更新日期：2006-02-26 00:00:00

abstract：:Meiosis-activating sterol (MAS) has been shown to induce mouse oocytes cultured in the presence of hypoxanthine (HX) to resume meiosis. The present research was conducted to determine whether amphotericin B or ketoconazole (a promoter and an inhibitor of production of MAS), affected oocyte maturation. Mouse cumulus ce...

journal_title：Molecular and cellular endocrinology

authors： Lu Z,Xia G,Byskov AG,Andersen CY

更新日期：2000-06-01 00:00:00

abstract：:The identification of estrogen-responsive genes in the heart, is necessary to understand estrogen-induced changes in cardiac function. Using Delta RNA fingerprinting, we demonstrate that a single injection of estradiol benzoate (50 microg, s.c.) revealed mRNA species that were elevated, down-regulated, or were unaffec...

journal_title：Molecular and cellular endocrinology

authors： Too CK,Giles A,Wilkinson M

更新日期：1999-04-25 00:00:00

abstract：:A quantitative assay using a reverse transcriptase-linked polymerase chain reaction has been developed for measuring the levels of rANP and iso-rANP mRNA. A linear correlation between total RNA template and amplified cDNA was obtained for the amplification of cDNA from both iso-rANP and rANP mRNAs even when both cDNAs...

journal_title：Molecular and cellular endocrinology

authors： Roy RN,Pang SC,Flynn TG

更新日期：1992-07-01 00:00:00

abstract：:Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream. The process involves especially hormone-poor Tg, which may favour hormone secretion by preventing competition with hormone-rich Tg for proteolytic degradation. To gain more insight into th...

journal_title：Molecular and cellular endocrinology

authors： Lisi S,Segnani C,Mattii L,Botta R,Marcocci C,Dolfi A,McCluskey RT,Pinchera A,Bernardini N,Marinò M

更新日期：2005-05-31 00:00:00

abstract：:Using primary cultures of porcine Sertoli cells as a model, the effects of ovine prolactin (oPRL) on Sertoli cell function were investigated through FSH binding. PRL treatment (0.3-5 ng/ml) induced a dose-dependent increase (ED50 = 5.10(-11) M) of 125I-FSH binding to Sertoli cells to a maximal stimulation (about 2.5-f...

journal_title：Molecular and cellular endocrinology

authors： Guillaumot P,Tabone E,Benahmed M

更新日期：1996-09-18 00:00:00

abstract：:Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP...

journal_title：Molecular and cellular endocrinology

authors： Flajollet S,Lefebvre B,Cudejko C,Staels B,Lefebvre P

更新日期：2007-05-30 00:00:00

abstract：:The relationship between ATP-induced uptake of 45Ca2+ and the ATP-induced changes in [Ca2+]i was investigated in rat FRTL-5 thyroid cells. Addition of 1 microCi 45Ca2+/ml together with ATP induced a time- and dose-dependent increase in uptake of 45Ca2+, the uptake being still significantly above control after 30 min. ...

journal_title：Molecular and cellular endocrinology

authors： Törnquist K

更新日期：1991-08-01 00:00:00

abstract：:The template for our understanding of the physiological role of the adrenal cortex was set by Hans Selye, who demonstrated its key involvement in the response to stress, of whatever origin, and who also introduced the terms glucocorticoid and mineralocorticoid. Despite this, from the late 1940s on there was certainly ...

journal_title：Molecular and cellular endocrinology

authors： Vinson GP

更新日期：2009-03-05 00:00:00

abstract：:Signaling mechanisms for Blaberus discoidalis hypertrehalosemic hormone (Bld-HrTH)-dependent glycogen phosphorylase activation were investigated in vitro using fat body of the tropical cockroach, B. discoidalis. Brief treatment of fat bodies with Bld-HrTH in the absence of extracellular Ca2+ showed a significant activ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Keeley LL

更新日期：1996-02-05 00:00:00

abstract：:The primary aim of this study was to evaluate the effects of arachidonic acid (AA) on calcium mobilization from intracellular compartments in digitonin-permeabilized granulosa cells isolated from the largest preovulatory follicles of laying hens. At low concentrations (ED50 0.2 microM) AA released 35% 45Ca from the en...

journal_title：Molecular and cellular endocrinology

authors： Hertelendy F,Molnár M,Jamaluddin M

更新日期：1992-02-01 00:00:00

abstract：:Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is...

journal_title：Molecular and cellular endocrinology

authors： Das SK,Balasubramanian P,Weerasekara YK

更新日期：2017-11-05 00:00:00

abstract：:Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse subma...

journal_title：Molecular and cellular endocrinology

authors： Ludwig G,Ganten D,Murakami K,Fasching U,Hackenthal E

更新日期：1987-04-01 00:00:00

abstract：:The capability of rat pituitary cells to express receptors for pituitary adenylate cyclase activating polypeptide (PACAP) and VIP was evaluated by binding studies and measurement of adenylate cyclase activity on whole gland preparations and by reverse transcriptase-polymerase chain reaction (TR-PCR) using specific pri...

journal_title：Molecular and cellular endocrinology

authors： Vertongen P,Velkeniers B,Hooghe-Peters E,Robberecht P

更新日期：1995-09-22 00:00:00

abstract：:Incorporation of p-chloromercuribenzene sulphonate (PCMBS) (1mM) in the assay medium for rat hepatic lactogenic receptor produced complete inhibition of binding of [125I]oPRL to the membrane. However, the presence of the thiol-reactive agent produced no effect on the binding of [125I]bGH to rat hepatic somatogenic rec...

journal_title：Molecular and cellular endocrinology

authors： Tsim KW,Cheng CH

更新日期：1984-11-01 00:00:00

abstract：:Dual-specificity phosphatase 6 (Dusp6) is a negative feedback mechanism of fibroblast growth factors (FGFs)/mitogen-activated protein kinase (MAPK)/ERK1/2 signaling. The aim of this study was to explore the expression of Dusp6 in human endometrial adenocarcinomas and the role of Dusp6 expression in the growth regulati...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Guo Q,Wang C,Yan L,Fu Y,Fan M,Zhao X,Li M

更新日期：2013-08-25 00:00:00

abstract：:Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by progesterone or synthetic progestins. Estrogen and progestin action is regulated at the pre-receptor level, by interconversion of active hormones (estradiol (E2), prog...

journal_title：Molecular and cellular endocrinology

authors： Rizner TL,Smuc T,Rupreht R,Sinkovec J,Penning TM

更新日期：2006-03-27 00:00:00

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian vertebrates including birds. In this study, the full-length cDNAs en...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Huang G,Li J,Meng F,He X,Leung FC

更新日期：2012-01-02 00:00:00

abstract：:Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration mo...

journal_title：Molecular and cellular endocrinology

authors： Chen L,Zhao Y,Li L,Xie L,Chen X,Liu J,Li X,Jin L,Li X,Ge RS

更新日期：2018-10-15 00:00:00

abstract：:Temperature-dependent sex determination (TSD) is a prime example of phenotypic plasticity in that gonadal sex is determined by the temperature of the incubating egg. In the red-eared slider turtle (Trachemys scripta), the effect of temperature can be overridden by exogenous ligands, i.e., sex steroid hormones and ster...

journal_title：Molecular and cellular endocrinology

authors： Matsumoto Y,Crews D

更新日期：2012-05-06 00:00:00

abstract：:It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state implicated in vascular complications. In this study, we investigated t...

journal_title：Molecular and cellular endocrinology

authors： Lamers D,Schlich R,Horrighs A,Cramer A,Sell H,Eckel J

更新日期：2012-10-15 00:00:00

abstract：:To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

journal_title：Molecular and cellular endocrinology

authors： Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

更新日期：2013-01-30 00:00:00

abstract：:Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in...

journal_title：Molecular and cellular endocrinology

authors： Lammel Lindemann JA,Angajala A,Engler DA,Webb P,Ayers SD

更新日期：2014-05-05 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to pigmentation to the regulation of feeding. One approach to unraveling the complexi...

journal_title：Molecular and cellular endocrinology

authors： Costa JL,Forbes S,Brennan MB,Hochgeschwender U

更新日期：2011-04-10 00:00:00

abstract：:Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of collagenase in uterine smooth muscle cells, a normal, non-inflammatory process that ...

journal_title：Molecular and cellular endocrinology

authors： Huang TT,Vinci JM,Lan L,Jeffrey JJ,Wilcox BD

更新日期：1999-06-25 00:00:00

abstract：:The first exon of the human androgen receptor (AR) contains a translated CAG (poly-glutamine) repeat. The repeat length is polymorphic in the normal population ranging from 8 to 35 repeats. Expansions to over 40 repeats lead to spinal bulbar muscular atrophy (SBMA), a late onset neurodegenerative disease. The repeat i...

journal_title：Molecular and cellular endocrinology

authors： Ferro P,Catalano MG,Dell'Eva R,Fortunati N,Pfeffer U

更新日期：2002-07-31 00:00:00

abstract：:The effects of 3.0 mM Mn2+ on parathyroid hormone (PTH) release, 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) were studied in vitro with use of parathyroid glands from rats and cattle. Mn2+ inhibited PTH release by about 70 and 60% at Ca2+ concentrations of less than 10 nM or 0.5 mM, respectively, and li...

journal_title：Molecular and cellular endocrinology

authors： Johansson H,Larsson R,Wallfelt C,Rastad J,Akerström G,Gylfe E

更新日期：1988-09-01 00:00:00

abstract：:The so-called calcium antagonist D-600 and agents that enhance the influx of calcium ions into nerve terminals during action potentials (4-aminopyridine, tetraethylammonium, guanidine) interact with alpha-adrenoceptors. The interaction was revealed by binding experiments in vitro with the alpha 2- and alpha 1-specific...

journal_title：Molecular and cellular endocrinology

authors： Glossmann H,Hornung R

更新日期：1980-09-01 00:00:00