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Metabolomics analysis of serum from subjects after occupational exposure to acrylamide using UPLC-MS.

Abstract：

:Since occupational exposure to acrylamide (ACR) may cause nerve damage, sensitive biomarkers to evaluate the early effects of ACR on human health are needed. In the present study, we have compared a group of individuals with occupational exposure to ACR (contact group, n = 65) with a group of individuals with no exposure (non-contact group, n = 60). Serum metabolomics analysis of the contact and non-contact groups was carried out using ultra performance liquid chromatograph/time of flight mass spectrometry, combined with multivariate analysis, to identify potential metabolites. Serum biochemical indexes of the contact and non-contact groups were also determined using an automatic biochemistry analyzer. There was a clear separation between the contact group and the non-contact group; receiver operator characteristic curve analysis suggested that phytosphingosine, 4E,15Z-bilirubin IXa and tryptophan were the best metabolites to use as biomarkers. Liver function was also found to be abnormal in the contact group. Important, ACR-related, metabolic changes were seen in the contact group and new biomarkers for assessing the toxicity of ACR on the central nervous system have been proposed. This study will provide a sound basis for exploring the toxic mechanisms and metabolic pathways of ACR.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Wang SY,Yu CP,Pan YL,Zhou XR,Xin R,Wang Y,Ma WW,Gao R,Wang C,Wu YH

doi

10.1016/j.mce.2017.02.003

subject

Has Abstract

pub_date

2017-03-15 00:00:00

pages

67-75

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30079-5

journal_volume

444

pub_type

杂志文章

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