The Klotho gene family as a regulator of endocrine fibroblast growth factors.

abstract：:Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular ...

journal_title：Molecular and cellular endocrinology

authors： Chopin L,Walpole C,Seim I,Cunningham P,Murray R,Whiteside E,Josh P,Herington A

更新日期：2011-06-20 00:00:00

abstract：:17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. Durin...

journal_title：Molecular and cellular endocrinology

authors： Moeller G,Adamski J

更新日期：2006-03-27 00:00:00

abstract：:A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R). Tetrapod and teleost MC2R orth...

journal_title：Molecular and cellular endocrinology

authors： Dores RM,Garcia Y

更新日期：2015-06-15 00:00:00

abstract：:[3-H]Melatonin administered in vivo in the rat cisterna magna became associated with a vinblastine-precipitable protein. Melatonin treatment decreased microtubule protein content by 44% in the arcuate-median eminence region and by 19% in the remaining hypothalamic block, being without significant effect on the cerebra...

journal_title：Molecular and cellular endocrinology

authors： Cardinali DP,Freire F

更新日期：1975-05-01 00:00:00

abstract：:Testicular peritubular cells produce paracrine mediators which modulate Sertoli cell function. The production of these mediators (P Mod-S) is controlled by androgens suggesting that mesenchymal-epithelial interactions play an important role in androgen action in the testis. We investigated whether mesenchymal cells fr...

journal_title：Molecular and cellular endocrinology

authors： Swinnen K,Cailleau J,Heyns W,Verhoeven G

更新日期：1989-03-01 00:00:00

abstract：:The steroidogenic acute regulatory (StAR) protein mediates cholesterol transport within the mitochondria, and its phosphorylation is believed to be required for steroidogenesis. Increased extracellular potassium concentrations (K(+)), angiotensin II (AngII), and adrenocorticotropic hormone (ACTH) induce aldosterone se...

journal_title：Molecular and cellular endocrinology

authors： Betancourt-Calle S,Calle RA,Isales CM,White S,Rasmussen H,Bollag WB

更新日期：2001-02-28 00:00:00

abstract：:The effects of chicken growth hormone (cGH) infusion on insulin-like growth factor (IGF-I) gene expression in rapidly-growing, meat-type chickens was investigated. Chicken GH was infused either continuously or in a pulsatile fashion to 8-week-old birds during a 7-day period. Following cGH infusion, both IGF-I peptide ...

journal_title：Molecular and cellular endocrinology

authors： Rosselot G,McMurtry JP,Vasilatos-Younken R,Czerwinski S

更新日期：1995-10-30 00:00:00

abstract：:Dual-specificity phosphatase 6 (Dusp6) is a negative feedback mechanism of fibroblast growth factors (FGFs)/mitogen-activated protein kinase (MAPK)/ERK1/2 signaling. The aim of this study was to explore the expression of Dusp6 in human endometrial adenocarcinomas and the role of Dusp6 expression in the growth regulati...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Guo Q,Wang C,Yan L,Fu Y,Fan M,Zhao X,Li M

更新日期：2013-08-25 00:00:00

abstract：:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

journal_title：Molecular and cellular endocrinology

authors： Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

更新日期：2015-01-05 00:00:00

abstract：:We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps deliv...

journal_title：Molecular and cellular endocrinology

authors： Haberkorn V,Heydel JM,Mounie J,Artur Y,Goudonnet H

更新日期：2002-04-25 00:00:00

abstract：:Molecular aspects of spermiogenesis can be studied using mouse mutants and spermatids developed in vitro. The azh/azh mutant is an attractive model system because structural abnormalities in the sperm head and the ectopic position of the manchette are associated with tail bending and looping. Spermatids, developing an...

journal_title：Molecular and cellular endocrinology

authors： Kierszenbaum AL,Tres LL

更新日期：2002-02-22 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:Pituitary and plasma pools from postmenopausal women and plasma pools from women at midcycle were fractionated by electrofocusing in sucrose density gradients. The biological LH activity was determined in each of the electrofocusing fractions by the use of an in vitro bioassay method. A heterogeneous profile of LH act...

journal_title：Molecular and cellular endocrinology

authors： Robertson DM,Van Damme MP,Diczfalusy E

更新日期：1977-11-01 00:00:00

abstract：:Endometriosis causes pelvic pain and infertility in women of reproductive age. We explored TNFalpha-induced specific signaling pathways and gene expressions in endometriotic stromal cells (ESCs). Based on the data of the pathway specific cDNA array, we analyzed the role of TAK1, which is believed to work as a common m...

journal_title：Molecular and cellular endocrinology

authors： Taniguchi F,Harada T,Miyakoda H,Iwabe T,Deura I,Tagashira Y,Miyamoto A,Watanabe A,Suou K,Uegaki T,Terakawa N

更新日期：2009-08-13 00:00:00

abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

journal_title：Molecular and cellular endocrinology

authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

更新日期：2016-11-15 00:00:00

abstract：OBJECTIVE:Significant attempts are being made to generate multifunctional, hybrid or peptide combinations as novel therapeutic strategies for type 2 diabetes, however this presents key challenges including design and pharmaceutical development. In this study, we evaluated metabolic properties of oral nutritional supple...

journal_title：Molecular and cellular endocrinology

authors： Pathak NM,Millar PJB,Pathak V,Flatt PR,Gault VA

更新日期：2018-01-15 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is involved in the growth and development of liver and brain during fetal life by acting through specific plasma membrane receptors. In an attempt to determine how the changes in IGF-I receptor number are regulated during development, we have compared [125I]IGF-I binding to membran...

journal_title：Molecular and cellular endocrinology

authors： Santos A,Yusta B,Fernández-Moreno MD,Blázquez E

更新日期：1994-05-01 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:Recent evidence suggests that lymphocytes produce prolactin (PRL). Here, we report the cDNA cloning and expression of PRL from normal human thymocytes. Sequence analysis showed that the thymocyte cDNA encodes a 23 kDa protein which is identical to pituitary PRL. RNA blot analysis showed that the thymocyte PRL mRNA is ...

journal_title：Molecular and cellular endocrinology

authors： O'Neal KD,Montgomery DW,Truong TM,Yu-Lee LY

更新日期：1992-09-01 00:00:00

abstract：:While the transcriptional effects of glucocorticoid hormone manipulation on the pituitary pro-opiomelanocortin (POMC) gene have been documented, it is not yet clear whether glucocorticoids activate additional post-transcriptional mechanisms to regulate POMC gene expression. We have used RNA probes that span exon/intro...

journal_title：Molecular and cellular endocrinology

authors： Autelitano DJ,Blum M,Roberts JL

更新日期：1989-10-01 00:00:00

abstract：:The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

journal_title：Molecular and cellular endocrinology

authors： Rudolph AE,Blasi ER,Delyani JA

更新日期：2000-07-25 00:00:00

abstract：:mRNA differential display polymerase chain reaction analysis was used to screen systematically for novel androgen-regulated genes in the human prostatic adenocarcinoma cell line LNCaP. A 232 bp PCR fragment was found to be consistently down-regulated by the synthetic androgen R1881. Sequencing revealed complete identi...

journal_title：Molecular and cellular endocrinology

authors： Ulrix W,Swinnen JV,Heyns W,Verhoeven G

更新日期：1999-09-10 00:00:00

abstract：:Over the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which have accompanied the fin-to-limb transition, an evolutionary st...

journal_title：Molecular and cellular endocrinology

authors： Kondo T,Hérault Y,Zákány J,Duboule D

更新日期：1998-05-25 00:00:00

abstract：:The first exon of the human androgen receptor (AR) contains a translated CAG (poly-glutamine) repeat. The repeat length is polymorphic in the normal population ranging from 8 to 35 repeats. Expansions to over 40 repeats lead to spinal bulbar muscular atrophy (SBMA), a late onset neurodegenerative disease. The repeat i...

journal_title：Molecular and cellular endocrinology

authors： Ferro P,Catalano MG,Dell'Eva R,Fortunati N,Pfeffer U

更新日期：2002-07-31 00:00:00

abstract：:In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst(1)-sst(5)) and the variety of si...

journal_title：Molecular and cellular endocrinology

authors： Cervia D,Casini G,Bagnoli P

更新日期：2008-05-14 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) protects the non-discriminating mineralocorticoid receptor from occupation by glucocorticoids. In man the enzyme is also highly expressed in the placenta where it is thought to also protect the fetus from the high circulating levels of maternal glu...

journal_title：Molecular and cellular endocrinology

authors： Li KX,Smith RE,Ferrari P,Funder JW,Krozowski ZS

更新日期：1996-06-18 00:00:00

abstract：:The metabolism of progesterone (PROG) by cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17α-hydroxyprogesterone (17-OHPROG) and 16α-hydroxyprogesterone (16-OHPROG) in humans. Unlike 17-OHPROG, 16-OHPROG is not metabolised further in steroidogenic tissue. While this metabolite ca...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart P,Africander D,Conradie R,Louw R,Swart AC

更新日期：2011-04-10 00:00:00

abstract：:Many genes that are required for fertility have been identified in model organisms (). Mutations in these genes cause infertility due to defects in development of the germ cell lineage, but the organism is otherwise healthy. Although human reproduction is undoubtedly as complex as that of other organisms, very few fer...

journal_title：Molecular and cellular endocrinology

authors： Fox MS,Reijo Pera RA

更新日期：2001-11-26 00:00:00

abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

journal_title：Molecular and cellular endocrinology

authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1989-06-01 00:00:00

abstract：:The screening of an oligo(dT)-primed prostate cDNA library with a human glandular kallikrein-1 (hGK-1) genomic DNA fragment resulted in the isolation of two different hGK-1 cDNAs. A 1.2 kb cDNA (pGK-1) contains an open reading frame of 510 bp, encoding the major part of the previously predicted hGK-1 protein (Schedlic...

journal_title：Molecular and cellular endocrinology

authors： Riegman PH,Vlietstra RJ,van der Korput HA,Romijn JC,Trapman J

更新日期：1991-04-01 00:00:00