16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction.

abstract：:Podocyte apoptosis in glomerular lesions has been found to have a dominant role in the progression of diabetic nephropathy. The present research aimed to explore the beneficial effect of icariin on diabetic podocytes by interfering in the process of apoptosis. Podocyte apoptosis was significantly exacerbated after hig...

journal_title：Molecular and cellular endocrinology

authors： Qiao C,Ye W,Li S,Wang H,Ding X

更新日期：2018-09-15 00:00:00

abstract：:Adrenocortical tumor (ACT), a rare tumor with a heterogeneous presentation, incompletely understood pathogenesis, and generally poor prognosis, occurs in 1-2 people per million and is even more uncommon in the pediatric population. Such rare cancers are a challenge to clinical practice. Exchange of experience, informa...

journal_title：Molecular and cellular endocrinology

authors： Ribeiro RC,Pinto EM,Zambetti GP,Rodriguez-Galindo C

更新日期：2012-03-31 00:00:00

abstract：:The relationship between the structure of human growth hormone (hGH) and the hormone-receptor interaction has been investigated using as probes monoclonal antibodies (Mabs) to hGH of defined epitope specificity profile. Seven high affinity Mabs were studied for their ability (i) to inhibit the binding of 125I-hGH to N...

journal_title：Molecular and cellular endocrinology

authors： Strasburger CJ,Binder L,Elberg G,Cohen-Chapnik N,Kohen F,Gertler A

更新日期：1989-11-01 00:00:00

abstract：:Digital video imaging indicated that about 80% of fura-2-loaded single human thyroid cells responded to TSH, resulting in an increase in intracellular Ca2+ concentration ([Ca2+]i). Most of the TSH-sensitive cells further responded to N6-(L-2-phenylisopropyl)-adenosine (PIA) showing a transient [Ca2+]i rise in a PIA do...

journal_title：Molecular and cellular endocrinology

authors： Yanagita Y,Okajima F,Sho K,Nagamachi Y,Kondo Y

更新日期：1996-04-19 00:00:00

abstract：:Activating mutations in the follicle-stimulating hormone (FSH) receptor (FSHR) gene are rarely detected due to the absence of a clearly defined phenotype, particularly in men. We here report the biochemical features of a novel mutation in the first extracellular loop of the FSHR. The mutation (N431I) was detected in a...

journal_title：Molecular and cellular endocrinology

authors： Casas-González P,Scaglia HE,Pérez-Solís MA,Durand G,Scaglia J,Zariñán T,Dias JA,Reiter E,Ulloa-Aguirre A

更新日期：2012-11-25 00:00:00

abstract：:The ovarian granulosa cell has previously been shown to be a site of insulin-like growth factor (IGF) I production, reception, and action. It is the objective of this study to characterize in greater detail the soluble IGF binding activity released by this cell type. To this end, use was made of granulosa cells from i...

journal_title：Molecular and cellular endocrinology

authors： Adashi EY,Resnick CE,Hernandez ER,Hurwitz A,Rosenfeld RG

更新日期：1990-12-21 00:00:00

abstract：:Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates. TH-binding sites are highly conserved in vertebrate TTR, however, piscine TTR has a longer N-terminus which is thought to influence TH-binding affinity and may influence TTR stability. We produc...

journal_title：Molecular and cellular endocrinology

authors： Morgado I,Melo EP,Lundberg E,Estrela NL,Sauer-Eriksson AE,Power DM

更新日期：2008-11-25 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:Thyroid hormone receptor alpha (TRalpha) and the oncoprotein v-erbA (a mutated form of TRalpha incapable of binding T3) bind as heterodimers with retinoid X receptor (RXR) to DNA sequences with different orientations of AGGTCA half sites. v-erbA can also form homodimers, whereas, TRalpha1 homodimerizes poorly. Therefo...

journal_title：Molecular and cellular endocrinology

authors： Zubkova I,Subauste JS

更新日期：2003-01-31 00:00:00

abstract：:In man, two isoforms of growth hormone receptor (GHR) have been reported. The first, hGHR corresponds to the original form described by Leung et al. (J. Biol. Chem. 264 (1987) 9905-9910). The second, hGHRd3, missing 22 N-terminal amino acids is encoded by an mRNA derived from alternative splicing and deletion of the t...

journal_title：Molecular and cellular endocrinology

authors： Esposito N,Paterlini P,Kelly PA,Postel-Vinay MC,Finidori J

更新日期：1994-07-01 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric cAMP-responsive luciferase so that real-time variations of intracellular cAMP concentration could be followed using oxiluciferin luminescence produced from cat...

journal_title：Molecular and cellular endocrinology

authors： Klett D,Meslin P,Relav L,Nguyen TM,Mariot J,Jégot G,Cahoreau C,Combarnous Y

更新日期：2016-10-15 00:00:00

abstract：:Rat thyroid tissue and cultured rat thyrocyte lines contain two thyroglobulin (Tg) mRNAs: a 9 kb rTg-1 mRNA encoding the 330, kDa Tg monomer and a recently described 0.95 kb rTg-2 mRNA. These transcripts have identical 5' coding sequences (641 nucleotides); however, the 3' end of rTg-2 is comprised of coding and non-c...

journal_title：Molecular and cellular endocrinology

authors： Graves PN,Davies TF

更新日期：1993-06-01 00:00:00

abstract：:In a series of in vivo and in vitro experiments, the concept has been established that breast cancer cells that express LH/CG or LHRH receptors can be targeted and destroyed by constructs consisting of a lytic peptide moiety and a 15-amino acid segment of the beta-chain of CG or by an LHRH lytic peptide conjugate. Dat...

journal_title：Molecular and cellular endocrinology

authors： Hansel W,Enright F,Leuschner C

更新日期：2007-01-02 00:00:00

abstract：:The heterodimeric 'pregnancy-specific' hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the beta-chain expressed in the absence of alpha-chain, is aberrantly expressed in a number of different tumors ...

journal_title：Molecular and cellular endocrinology

authors： Delves PJ,Iles RK,Roitt IM,Lund T

更新日期：2007-01-02 00:00:00

abstract：:In order to differentiate whether activation of NaK-ATPase in thyroid thermogenesis is due to increased numbers of active 'sodium pump' units or due to a change in the kinetics of the enzyme, the effect of T3 on activation energy (Ea) of NaK-ATPase was determined in rat liver, kidney and brain. Injection of T3 produce...

journal_title：Molecular and cellular endocrinology

authors： Rahimifar M,Ismail-Beigi

更新日期：1977-02-01 00:00:00

abstract：:We investigated the involvement of protein synthesis in the stimulatory action of thyroid hormones on amino acid accumulation and characterized K(+) currents involved in the hyperpolarizing effect of thyroxine (T(4)) on Sertoli cells. Immature rat testes were incubated in Krebs Ringer-bicarbonate buffer (KRb) in the p...

journal_title：Molecular and cellular endocrinology

authors： Menegaz D,Zamoner A,Royer C,Leite LD,Bortolotto ZA,Silva FR

更新日期：2006-02-26 00:00:00

abstract：:The effects of calcitonin (CT) on the cellular transport and accumulation of Ca were studied in bone cells grown in primary culture. The following sequence of events was detected: (1) After 1--2 h of incubation with CT the initial rate of Ca influx into bone cells transiently increased. A longer incubation with CT (3-...

journal_title：Molecular and cellular endocrinology

authors： Eilam Y,Szydel N,Harell A

更新日期：1980-06-01 00:00:00

abstract：:Here we report the identification and characterization of ghrelin (GRLN) receptors in goldfish Carassius auratus. We identified four distinct mRNAs generated from four different genes. Those were roughly divided into two types, based on the number of amino acids and amino acid sequence similarity; one composed of 360-...

journal_title：Molecular and cellular endocrinology

authors： Kaiya H,Miura T,Matsuda K,Miyazato M,Kangawa K

更新日期：2010-10-07 00:00:00

abstract：:Granulosa cell (GC) expressed androgen receptors (AR) and intrafollicular androgens are central to fertility. The transactivating domain of the AR contains a polymorphic CAG repeat sequence, which is linked to the transcriptional activity of AR and may influence the GC function. This study aims to evaluate the effects...

journal_title：Molecular and cellular endocrinology

authors： Borgbo T,Macek M Sr,Chrudimska J,Jeppesen JV,Hansen LL,Andersen CY

更新日期：2016-01-05 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1) is a protein expressed in 3T3-L1 adipocytes that is involved in most, if not all of the biological responses to insulin. Chronic exposure of these cells to insulin down-regulates IRS-1 by stimulating its degradation (Rice, K.M., Turnbow, M.A. and Garner, C.W. (1993) Biochem. Biophy...

journal_title：Molecular and cellular endocrinology

authors： Smith LK,Rice KM,Garner CW

更新日期：1996-08-30 00:00:00

abstract：:We studied the functional properties of hepatic glucagon receptors during rat development. Glucagon binding to liver membranes and isolated hepatocytes was significantly less in foetuses and weaning rats than in adult animals, reflecting changes in the number of receptors rather than any change in receptor affinity fo...

journal_title：Molecular and cellular endocrinology

authors： Blázquez E,Perez Castillo A,de Diego JG

更新日期：1987-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis. It is also a central player in energy metabolism, inflammation and immunity. As an important nuclear transcription factor, PPARγ can regulate the expression and function of genes or biological processes directly or indirectly ...

journal_title：Molecular and cellular endocrinology

authors： Su Y,Shen X,Chen J,Isales CM,Zhao J,Shi XM

更新日期：2018-08-15 00:00:00

abstract：:Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression ...

journal_title：Molecular and cellular endocrinology

authors： Kim WK,Oh KJ,Choi HR,Park A,Han BS,Chi SW,Kim SJ,Bae KH,Lee SC

更新日期：2015-11-15 00:00:00

abstract：:The effects of chicken growth hormone (cGH) infusion on insulin-like growth factor (IGF-I) gene expression in rapidly-growing, meat-type chickens was investigated. Chicken GH was infused either continuously or in a pulsatile fashion to 8-week-old birds during a 7-day period. Following cGH infusion, both IGF-I peptide ...

journal_title：Molecular and cellular endocrinology

authors： Rosselot G,McMurtry JP,Vasilatos-Younken R,Czerwinski S

更新日期：1995-10-30 00:00:00

abstract：:A pair of glands (Y-organs) in crustaceans synthesize and secrete ecdysteroid hormones; the obligate precursor for synthesis is circulating cholesterol. Ecdysteroid output by the Y-organs is regulated negatively by an eyestalk neurosecretory peptide, molt-inhibiting hormone (MIH). The question was addressed, does MIH ...

journal_title：Molecular and cellular endocrinology

authors： Spaziani E,Wang WL

更新日期：1993-09-01 00:00:00

abstract：:Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. GWAS, however, are by nature gene agnostic, and SNPs reaching the appropriate statistical threshold for a given phenotype can appear a...

journal_title：Molecular and cellular endocrinology

authors： Yeo GS

更新日期：2014-11-01 00:00:00

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:Octopamine serves as a neurotransmitter in the glandular lobe of the locust corpus cardiacum where it regulates adipokinetic hormone (AKH) secretion from intrinsic neurosecretory cells. Two AKHs (AKH I and II) from the corpus cardiacum of Locusta have been sequenced and synthesized. We have now demonstrated that octop...

journal_title：Molecular and cellular endocrinology

authors： Pannabecker T,Orchard I

更新日期：1986-12-01 00:00:00

abstract：:Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative association with human diseases makes them promising pharmacological targets because of the large potential to develop ligands. LXR are mainly considered as intracellular cholesterol "sensors" whose a...

journal_title：Molecular and cellular endocrinology

authors： Viennois E,Mouzat K,Dufour J,Morel L,Lobaccaro JM,Baron S

更新日期：2012-04-04 00:00:00