当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Destruction of breast cancers and their metastases by lytic peptide conjugates in vitro and in vivo.

Destruction of breast cancers and their metastases by lytic peptide conjugates in vitro and in vivo.

Abstract：

:In a series of in vivo and in vitro experiments, the concept has been established that breast cancer cells that express LH/CG or LHRH receptors can be targeted and destroyed by constructs consisting of a lytic peptide moiety and a 15-amino acid segment of the beta-chain of CG or by an LHRH lytic peptide conjugate. Data obtained in vitro established the validity of this concept, showed the specificities of the Hecate-betaCG, and Phor14 and Phor21-betaCG conjugates in killing cells that express functional LH/CG receptors and proved that the LH/CG receptor capacity is directly related to the compound's specificity. In in vivo experiments, Hecate-betaCG, Phor14-betaCG, and Phor21-betaCG(ala) each caused highly significant reductions of tumor volume and tumor burden in nude mice bearing breast cancer xenografts; Hecate and Phor21 alone or conjugated with non-specific peptides were not effective. Most importantly, the lytic peptide conjugates were all highly effective in targeting and destroying disseminated breast cancer metastases in lymph nodes, bones, lungs and other organs.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Hansel W,Enright F,Leuschner C

doi

10.1016/j.mce.2005.12.056

subject

Has Abstract

pub_date

2007-01-02 00:00:00

pages

183-9

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(06)00490-4

journal_volume

260-262

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Inhibin/activin subunits and activin receptor are co-expressed in Leydig tumor cells.

    abstract：:The expression of genes encoding inhibin/activin subunits and activin receptor was examined in four cultured Leydig tumor cells (MA-10, I-10, R2C, and LC-540). Inhibin alpha-subunit gene was highly expressed in Leydig tumor cell lines except LC-540. Both inhibin beta-A- and beta-B-subunit mRNAs were present in low lev...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(93)90061-n

    authors： Chen CL,Pignataro OP,Feng ZM

    更新日期：1993-07-01 00:00:00

  • The Klotho gene family as a regulator of endocrine fibroblast growth factors.

    abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.10.052

    authors： Kurosu H,Kuro-O M

    更新日期：2009-02-05 00:00:00

  • Changes in endonuclease activity during growth and regression of the Shionogi mammary carcinoma.

    abstract：:Autodigestion of nuclei isolated from the androgen-dependent Shionogi mouse mammary carcinoma revealed the presence of endogenous endonuclease activity which was stimulated by Ca2+ and Mg2+ and generated a repeating pattern of DNA fragments with an average monomeric size of 179 base pairs. The nuclear concentration of...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90144-9

    authors： Giles MG,Rennie PS,Bruchovsky N

    更新日期：1986-05-01 00:00:00

  • Stem cell function and plasticity in the normal physiology of the adrenal cortex.

    abstract：:The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2020.111043

    authors： Hammer GD,Basham KJ

    更新日期：2021-01-01 00:00:00

  • Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.

    abstract：:Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcuta...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.10.004

    authors： Rodriguez-Sosa JR,Bondareva A,Tang L,Avelar GF,Coyle KM,Modelski M,Alpaugh W,Conley A,Wynne-Edwards K,França LR,Meyers S,Dobrinski I

    更新日期：2014-12-01 00:00:00

  • Epididymal genomics and the search for a male contraceptive.

    abstract：:This report represents the joint efforts of three laboratories, one with a primary interest in understanding regulatory processes in the epididymal epithelium (TTT) and two with a primary interest in identifying and characterizing new contraceptive targets (DSJ and SAJ). We have developed a highly refined mouse epidid...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.12.042

    authors： Turner TT,Johnston DS,Jelinsky SA

    更新日期：2006-05-16 00:00:00

  • Thyroid dysfunction in megalin deficient mice.

    abstract：:Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream. The process involves especially hormone-poor Tg, which may favour hormone secretion by preventing competition with hormone-rich Tg for proteolytic degradation. To gain more insight into th...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.03.009

    authors： Lisi S,Segnani C,Mattii L,Botta R,Marcocci C,Dolfi A,McCluskey RT,Pinchera A,Bernardini N,Marinò M

    更新日期：2005-05-31 00:00:00

  • Role of metal ions in ligand-receptor interaction: insights from structural studies.

    abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.11.023

    authors： Ananthanarayanan VS,Kerman A

    更新日期：2006-02-26 00:00:00

  • Analysis of rat placental plasma membrane proteins by two-dimensional gel electrophoresis.

    abstract：:The placenta plays an essential role in fetal growth and the maintenance of pregnancy and its functions are strictly controlled in a stage-specific manner. To gain an insight into placental functions and their regulation, we analyzed the plasma membrane proteins of rat placenta by two-dimensional polyacrylamide gel el...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03682-2

    authors： Ishimura R,Noda K,Hattori N,Shiota K,Ogawa T

    更新日期：1995-12-29 00:00:00

  • Differentiation of Seminiferous Tubule-Associated Stem Cells into Leydig Cell and Myoid Cell Lineages.

    abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2021.111179

    authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

    更新日期：2021-01-27 00:00:00

  • Modulation by melatonin of protein secretion from melanoma cells: is cAMP involved?

    abstract：:The pineal hormone melatonin modulates constitutive protein secretion from melanoma M2R cells. Nanomolar concentrations of melatonin inhibited protein secretion early after plating or at low cell density, but facilitated it late after plating or at high cell density. Inhibition by melatonin of adenylate cyclase is the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03592-u

    authors： Bubis M,Zisapel N

    更新日期：1995-08-11 00:00:00

  • Relaxin and the 'Milky Way': The lactocrine hypothesis and maternal programming of development.

    abstract：:Maternal effects on early postnatal development in mammals are mediated, in part, by milk-borne bioactive factors transmitted from mother to nursing offspring. The term 'lactocrine' was coined to describe this mode of signaling. Relaxin (RLX), one of a family of neohormones found in mammals, is detectable in milk from...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2019.01.003

    authors： Bagnell CA,Bartol FF

    更新日期：2019-05-01 00:00:00

  • Pregnenolone synthesis in immature rat Sertoli cells.

    abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00155-0

    authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

    更新日期：1999-11-25 00:00:00

  • Antisense oligonucleotide strategies in physiology.

    abstract：:Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA cod...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/0303-7207(94)90254-2

    authors： Baertschi AJ

    更新日期：1994-05-01 00:00:00

  • Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells.

    abstract：:Oleic (OA) and linoleic (LA) fatty acids may be important regulators of Slc2a4 gene (GLUT4 protein) in skeletal muscle, thus participating in insulin resistance. We investigated the effect of OA and LA on the Slc2a4/GLUT4 expression in L6 muscle cells; as well as potential transcriptional regulators. OA and LA (50-400...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.12.001

    authors： Poletto AC,Furuya DT,David-Silva A,Ebersbach-Silva P,Santos CL,Corrêa-Giannella ML,Passarelli M,Machado UF

    更新日期：2015-02-05 00:00:00

  • Mutational analysis of rare subtypes of congenital adrenal hyperplasia in a highly inbred population.

    abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2017.08.022

    authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

    更新日期：2018-02-05 00:00:00

  • Parathyroid hormone acute vascular effect is mediated by decreased Ca2+ uptake and enhanced cAMP level.

    abstract：:Cardiovascular effects of parathyroid hormone (PTH) have been recently described. Pharmacological doses of PTH both reduce arterial pressure and increase blood flow of vascular beds. Two possible cellular mechanisms were investigated: (a) transmembrane Ca2+ fluxes and (b) cyclic AMP response in vascular smooth muscle....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90231-1

    authors： Schleiffer R,Bergmann C,Pernot F,Gairard A

    更新日期：1989-11-01 00:00:00

  • Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix.

    abstract：:If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2006.10.014

    authors： Delvenne P,Herman L,Kholod N,Caberg JH,Herfs M,Boniver J,Jacobs N,Hubert P

    更新日期：2007-01-29 00:00:00

  • Expression of adrenocortical steroidogenic acute regulatory (StAR) protein is influenced by chromaffin cells.

    abstract：:Cell-cell interactions are crucial role for the proper functioning of endocrine glands. We recently demonstrated that interactions of chromaffin and cortical cells are important for adrenocortical steroidogenesis. However, the molecular mechanisms have not been elucidated and it is unclear if this involves acute and/o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00267-7

    authors： Haidan A,Bornstein SR,Liu Z,Walsh LP,Stocco DM,Ehrhart-Bornstein M

    更新日期：2000-07-25 00:00:00

  • Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary.

    abstract：:We have previously reported that LHCGR expression in the ovary is regulated through a post-transcriptional mechanism involving an mRNA binding protein designated as LRBP, which is regulated, at least in part, by a non-coding RNA, miR-122. Our present study examined the regulatory role of miR-122 in FSH-induced LHCGR e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.12.002

    authors： Menon B,Gulappa T,Menon KM

    更新日期：2017-02-15 00:00:00

  • Full oestrogenic activity of C19-delta 5 adrenal steroids in rat pituitary lactotrophs and somatotrophs.

    abstract：:Oestrogens are known to exert specific stimulatory effects on basal and dopamine (DA)-inhibited prolactin (PRL) release as well as on PRL cell content in rat adenohypophysial cells in primary culture. Recently, we have demonstrated that classical oestrogens increase growth hormone (GH) release and cellular GH content ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90138-4

    authors： Simard J,Vincent A,Duchesne R,Labrie F

    更新日期：1988-02-01 00:00:00

  • Seawater transfer down-regulates C-type natriuretic peptide-3 expression in prolactin-producing cells of Japanese eel: Negative correlation with plasma chloride concentration.

    abstract：:In euryhaline fishes, atrial and B-type natriuretic peptides are important hormones in hypo-osmoregulation, whereas osmoregulatory functions of C-type natriuretic peptides (CNPs) remain to be investigated. Although four CNP isoforms (CNP1-4) are mainly expressed in the brain, multiorgan expression of CNP3 was found in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2020.110780

    authors： Katayama Y,Wong MK,Kusakabe M,Fujio M,Takahashi N,Yaguchi M,Tsukada T

    更新日期：2020-05-01 00:00:00

  • Vasculoprotective effects of somatostatin receptor subtypes.

    abstract：:We have shown that somatostatin agonist peptide CH275, selective to somatostatin receptor (sst) subtypes 1,4, was more effective in preventing intimal hyperplasia than the sst2,3,5-selective octreotide, raising the question what are the separate roles of the sst1- and 4-subtypes. Here, we dissect this observation furt...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.08.018

    authors： Tigerstedt NM,Aavik E,Aavik S,Savolainen-Peltonen H,Hayry P

    更新日期：2007-12-15 00:00:00

  • Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP.

    abstract：:Gonadotropin-releasing hormone (GnRH) neurons coordinate reproduction. However, whether GnRH neurons directly sense free fatty acids (FFAs) is unknown. We investigated the individual effects of the FFAs docosahexaenoic acid (DHA), palmitate, palmitoleate, and oleate (100 μM each) on Gnrh mRNA expression in the mHypoA-...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.02.019

    authors： Tran DQ,Ramos EH,Belsham DD

    更新日期：2016-05-05 00:00:00

  • Neuropeptide Y impairs insulin-stimulated translocation of glucose transporter 4 in 3T3-L1 adipocytes through the Y1 receptor.

    abstract：:Neuropeptide Y (NPY) is expressed in adipose tissue and is involved in adipocyte metabolism. Although NPY impacts on glucose utilization in vivo, the underlying cellular mechanism is yet to be fully elucidated. In this study we investigated the effect of NPY on the insulin-stimulated translocation of glucose transport...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.07.028

    authors： Gericke MT,Schröder T,Kosacka J,Nowicki M,Klöting N,Spanel-Borowski K

    更新日期：2012-01-02 00:00:00

  • Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus.

    abstract：:During critical periods of development, hypothyroidism causes abnormalities of the central nervous system such as incomplete maturation of neuronal and glial cells, reduction in synaptic densities and myelin deficits. In this study expression of development regulated genes, ie transcription of beta-actin, sema 3F, CRM...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00592-5

    authors： Wong CC,Leung MS

    更新日期：2001-11-26 00:00:00

  • The adrenal cortex and life.

    abstract：:The template for our understanding of the physiological role of the adrenal cortex was set by Hans Selye, who demonstrated its key involvement in the response to stress, of whatever origin, and who also introduced the terms glucocorticoid and mineralocorticoid. Despite this, from the late 1940s on there was certainly ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.09.008

    authors： Vinson GP

    更新日期：2009-03-05 00:00:00

  • Molecular characterization of a corticotropin (ACTH) receptor.

    abstract：:We have used a new methodology to generate a monospecific antiserum to the corticotropin (ACTH) receptor on mouse Y-1 adrenal cells. Using immunoaffinity chromatography the ACTH receptor was purified, and the molecular structure and 125I-ACTH binding characteristics were determined. A molecular weight (Mr) of 225 000 ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90099-7

    authors： Bost KL,Blalock JE

    更新日期：1986-01-01 00:00:00

  • Mineralocorticoid receptor and embryonic stem cell models: molecular insights and pathophysiological relevance.

    abstract：:Mineralocorticoid receptor (MR) signaling is pivotal for numerous physiological processes and implicated in various pathological conditions concerning among others, tight epithelia, central nervous and cardiovascular systems. For decades, the pleiotropic actions of MR have been investigated using animal and cellular m...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2011.06.036

    authors： Le Menuet D,Munier M,Campostrini G,Lombès M

    更新日期：2012-03-24 00:00:00

  • Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation.

    abstract：:Estrogen receptor β (ERβ) and its isoforms have different putative functions and expression patterns in prostate cancer. Current studies on 5'-most exons, 0K and 0N, show that their respective promoters are actively involved in transcription. These data, however, do not explain why ERβ isoforms are differentially expr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.06.023

    authors： Lee MT,Ouyang B,Ho SM,Leung YK

    更新日期：2013-08-25 00:00:00