Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix.

Abstract:

:If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.

journal_name

Mol Cell Endocrinol

authors

Delvenne P,Herman L,Kholod N,Caberg JH,Herfs M,Boniver J,Jacobs N,Hubert P

doi

10.1016/j.mce.2006.10.014

subject

Has Abstract

pub_date

2007-01-29 00:00:00

pages

1-5

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(06)00500-4

journal_volume

264

pub_type

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