Melatonin-and serotonin-stimulated release of vasopressin from rat neurohypophysis in vitro.

Abstract:

:In order to study the control of vasopressin-release, the effect of a series of potential agents was studied in an in vitro perifusion system of rat neurohypophysis after in vivo treatment with nialamide, a monoamine oxidase inhibitor. In this system, metlatonin stimulated vasopressin-release in a dose-dependent manner (1 x 10-8 to 1 x 10-3 M). Serotonin (1 x 10-3 M) also led to a significant increase of vasopressin-release whereas quipazine (1 x 10-3 M), a putative serotonin agonist and monoamine oxidase inhibitor, caused a 3-fold stimulation of the release of the neurohormone. The stimulatory effects of melatonin and serotonin were prevented by omission of Ca2+ combined to an excess of Mg2+ (12mM) in the perifusion medium. 1 x 10-6 M somatostatin did not affect basal or melatonin-stimulated vasopressin-release. These results show that melatonin and serotonin can have a direct stimulatory effect on vasopressin release at the neurohypophyseal level.

journal_name

Mol Cell Endocrinol

authors

Lemay A,Brouillette A,Denizeau F,Lavoie M

doi

10.1016/0303-7207(79)90103-5

subject

Has Abstract

pub_date

1979-05-01 00:00:00

pages

157-66

issue

2

eissn

0303-7207

issn

1872-8057

pii

0303-7207(79)90103-5

journal_volume

14

pub_type

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