Abstract：
:Gonadotropin-releasing hormone receptor (GnRH-R) activation stimulates synthesis and release of gonadotropins in the vertebrate pituitary and also mediates other processes both in the brain and in peripheral tissues. To better understand the differential function of multiple GnRH-R paralogs, three GnRH-R genes (gnrhr1a, 1b, and 2) were isolated and characterized in the European eel. All three gnrhr genes were expressed in the brain and pituitary of pre-pubertal eels, and also in several peripheral tissues, notably gills and kidneys. During hormonally induced sexual maturation, pituitary expression of gnrhr1a (female) and gnrhr2 (male and female) was up-regulated in parallel with gonad development. In the brain, a clear regulation during maturation was seen only for gnrhr2 in the midbrain, with highest levels recorded during early vitellogenesis. These data suggest that GnRH-R2 is the likely hypophysiotropic GnRH-R in male eel, while both GnRH-R1a and GnRH-R2 seems to play this role in female eels.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Peñaranda DS,Mazzeo I,Hildahl J,Gallego V,Nourizadeh-Lillabadi R,Pérez L,Asturiano JF,Weltzien FAdoi
10.1016/j.mce.2013.01.025subject
Has Abstractpub_date
2013-04-30 00:00:00pages
1-14issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(13)00057-9journal_volume
369pub_type
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