Endocannabinoids, sperm functions and energy metabolism.

abstract：:The intranuclear locations at which rat uterine estrogen receptors interact with chromatin have been probed using digestions performed with DNAase I and micrococcal nuclease. Exposure to nuclease has been controlled to effect limited to extensive digestion of nuclear DNA under conditions which maintain the integrity o...

journal_title：Molecular and cellular endocrinology

authors： Pavlik EJ,Katzenellenbogen BS

更新日期：1982-04-01 00:00:00

abstract：:The placenta plays an essential role in fetal growth and the maintenance of pregnancy and its functions are strictly controlled in a stage-specific manner. To gain an insight into placental functions and their regulation, we analyzed the plasma membrane proteins of rat placenta by two-dimensional polyacrylamide gel el...

journal_title：Molecular and cellular endocrinology

authors： Ishimura R,Noda K,Hattori N,Shiota K,Ogawa T

更新日期：1995-12-29 00:00:00

abstract：:The ovulatory process is characterized by tissue wounding and, after oocyte expulsion, by healing being connected to the formation of a corpus luteum (CL). The ovulatory event thus compares with a sterile inflammation. The concept is forwarded that the ovulatory process depends on innate immunity (INIM) function. The ...

journal_title：Molecular and cellular endocrinology

authors： Spanel-Borowski K

更新日期：2011-02-10 00:00:00

abstract：:The transcription factors involved in the activation of cardiac gene expression by angiotensin II (Ang II) in vivo are not well understood. Here we studied the contribution of transcriptional elements to the activation of the cardiac B-type natriuretic peptide (BNP) gene promoter by Ang II in conscious rats and in ang...

journal_title：Molecular and cellular endocrinology

authors： Majalahti T,Suo-Palosaari M,Sármán B,Hautala N,Pikkarainen S,Tokola H,Vuolteenaho O,Wang J,Paradis P,Nemer M,Ruskoaho H

更新日期：2007-07-15 00:00:00

abstract：:Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling path...

journal_title：Molecular and cellular endocrinology

authors： Schedlich LJ,Yenson VM,Baxter RC

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS...

journal_title：Molecular and cellular endocrinology

authors： Bernardi S,Fabris B,Thomas M,Toffoli B,Tikellis C,Candido R,Catena C,Mulatero P,Barbone F,Radillo O,Zauli G,Secchiero P

更新日期：2014-08-25 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:Although earlier studies focused on the hormonal regulation of antral and preovulatory follicles, recent studies indicate the importance of the hormonal control mechanism for preantral follicles. The endocrine hormone FSH is not only a survival factor for early antral follicles but also a potent growth and differentia...

journal_title：Molecular and cellular endocrinology

authors： Hsueh AJ,McGee EA,Hayashi M,Hsu SY

更新日期：2000-05-25 00:00:00

abstract：:Digital video imaging indicated that about 80% of fura-2-loaded single human thyroid cells responded to TSH, resulting in an increase in intracellular Ca2+ concentration ([Ca2+]i). Most of the TSH-sensitive cells further responded to N6-(L-2-phenylisopropyl)-adenosine (PIA) showing a transient [Ca2+]i rise in a PIA do...

journal_title：Molecular and cellular endocrinology

authors： Yanagita Y,Okajima F,Sho K,Nagamachi Y,Kondo Y

更新日期：1996-04-19 00:00:00

abstract：:The addition of glucose to suspensions of HIT-T15 insulinoma cells caused a small, transient acidification followed by a gradual, progressive alkalinisation, as assessed by the fluorescent pH-sensitive dye 2',7'-biscarboxyethyl-5'-(6')-carboxyfluorescein (BCECF). Treatment of cells with acetate or lactate produced an ...

journal_title：Molecular and cellular endocrinology

authors： Trebilcock R,Lynch A,Tomlinson S,Best L

更新日期：1990-05-28 00:00:00

abstract：:The introduction of a targeted insertion mutation into exon 2 of the gene coding for the glucocorticoid receptor (GR) enabled production of glucocorticoid receptor knock-out (GRKO) mice. GRKO mice on a C57BL/6/129sv mixed genetic background show a variable phenotype, with 90% of -/- mice dying at birth with respirator...

journal_title：Molecular and cellular endocrinology

authors： Cole TJ,Myles K,Purton JF,Brereton PS,Solomon NM,Godfrey DI,Funder JW

更新日期：2001-02-28 00:00:00

abstract：:Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex. In control guinea pigs, a number of morphologic differences distinguished the ZF from the ZR, including the presence of far m...

journal_title：Molecular and cellular endocrinology

authors： Yuan BB,Tchao R,Funae Y,Voigt JM,Colby HD

更新日期：1998-11-25 00:00:00

abstract：:In type 2 diabetes, a strong correlation between intramyocellular lipid accumulation and insulin resistance exists but whether intramyocellular accumulation is a cause or a consequence of insulin resistance is not clear. Lipid accumulation and response to insulin were evaluated in primary human myotubes derived from n...

journal_title：Molecular and cellular endocrinology

authors： Aguer C,Mercier J,Kitzmann M

更新日期：2010-02-05 00:00:00

abstract：:We have studied the effect of the adenylate cyclase-stimulating agent forskolin on expression of components of the plasminogen activation system in the human fibrosarcoma cell line HT-1080. By enzyme-linked immunosorbent assays, forskolin was found to cause a 2 to 4-fold decrease in intracellular and culture medium le...

journal_title：Molecular and cellular endocrinology

authors： Georg B,Riccio A,Andreasen P

更新日期：1990-08-20 00:00:00

abstract：:Receptors for calcitriol are described in human decidua. They exhibit a dissociation constant of 35 +/- 6 pM and they are at concentrations similar to those found in other tissues (0.45 +/- 0.04 fmol/micrograms DNA). They are highly specific for calcitriol since neither of the other vitamin D3 derivatives nor the ster...

journal_title：Molecular and cellular endocrinology

authors： Delvin EE,Gagnon L,Arabian A,Gibb W

更新日期：1990-07-09 00:00:00

abstract：:Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of collagenase in uterine smooth muscle cells, a normal, non-inflammatory process that ...

journal_title：Molecular and cellular endocrinology

authors： Huang TT,Vinci JM,Lan L,Jeffrey JJ,Wilcox BD

更新日期：1999-06-25 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These ligand-activated transcription factors are implicated in the regulation of lipid metabolism and adipocyte differentiation and in the regulation of anti-inflammatory processes. In order to bind to DNA ...

journal_title：Molecular and cellular endocrinology

authors： Gorla-Bajszczak A,Juge-Aubry C,Pernin A,Burger AG,Meier CA

更新日期：1999-01-25 00:00:00

abstract：:Granulosa cell (GC) expressed androgen receptors (AR) and intrafollicular androgens are central to fertility. The transactivating domain of the AR contains a polymorphic CAG repeat sequence, which is linked to the transcriptional activity of AR and may influence the GC function. This study aims to evaluate the effects...

journal_title：Molecular and cellular endocrinology

authors： Borgbo T,Macek M Sr,Chrudimska J,Jeppesen JV,Hansen LL,Andersen CY

更新日期：2016-01-05 00:00:00

abstract：:The enzyme aromatase converts androgens to estrogens, which have recently been postulated to be essential for testicular development and fertility. Understanding the mechanisms that regulate aromatase activity in the testis may therefore have implications for treatment of male infertility. Aromatase is encoded by the ...

journal_title：Molecular and cellular endocrinology

authors： Sierens J,Jakody I,Poobalan Y,Meachem SJ,Knower K,Young MJ,Sirianni R,Pezzi V,Clyne CD

更新日期：2010-07-29 00:00:00

abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

journal_title：Molecular and cellular endocrinology

authors： Lewy H,Ashkenazi IE,Naor Z

更新日期：2003-05-30 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00

abstract：:Patients with PS or non-syndromic deafness were submitted to genetic/functional analyzes of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator FOXI1, and of the potassium channel KCNJ10. SLC26A4 was the most frequently mutated gene. An altered intracellular localization with immunocyt...

journal_title：Molecular and cellular endocrinology

authors： Cirello V,Bazzini C,Vezzoli V,Muzza M,Rodighiero S,Castorina P,Maffini A,Bottà G,Persani L,Beck-Peccoz P,Meyer G,Fugazzola L

更新日期：2012-04-04 00:00:00

abstract：:Protein phosphorylation-dephosphorylation appears to be an essential component in the regulation of many cellular processes by hormones and drugs. This concept has developed primarily from in vitro biochemical studies in which various purified proteins have been phosphorylated and dephosphorylated by distinct protein ...

journal_title：Molecular and cellular endocrinology

authors： Manning DR,DiSalvo J,Stull JT

更新日期：1980-07-01 00:00:00

abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

journal_title：Molecular and cellular endocrinology

authors： Ananthanarayanan VS,Kerman A

更新日期：2006-02-26 00:00:00

abstract：:Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of An...

journal_title：Molecular and cellular endocrinology

authors： Gowrisankar YV,Clark MA

更新日期：2016-12-05 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:Using a combination of in vitro assays we have evaluated whether DDT metabolites can interact with the progesterone receptor pathway in yeast expressing human progesterone receptor (hPR) and in T47D human breast cancer cells which express endogenous hPR. In transactivation assays using both yeast and T47D cells, o,p'-...

journal_title：Molecular and cellular endocrinology

authors： Klotz DM,Ladlie BL,Vonier PM,McLachlan JA,Arnold SF

更新日期：1997-04-25 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:The effects of chicken growth hormone (cGH) infusion on insulin-like growth factor (IGF-I) gene expression in rapidly-growing, meat-type chickens was investigated. Chicken GH was infused either continuously or in a pulsatile fashion to 8-week-old birds during a 7-day period. Following cGH infusion, both IGF-I peptide ...

journal_title：Molecular and cellular endocrinology

authors： Rosselot G,McMurtry JP,Vasilatos-Younken R,Czerwinski S

更新日期：1995-10-30 00:00:00

abstract：:The effects of prostaglandins (PGs) on rat pineal metabolism were examined in vitro. PGE2 (0.01-1 microM) increased the activity of serotonin-N-acetyltransferase (SNAT), the stimulation curve exhibiting a maximum at 0.1 microM. PGE1 increased SNAT activity only at the highest dose (1 microM) whereas PGF2 alpha, 15-ket...

journal_title：Molecular and cellular endocrinology

authors： Ritta MN,Cardinali DP

更新日期：1981-08-01 00:00:00