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Epidermal growth factor antagonizes ovarian theca-interstitial cytodifferentiation.

Abstract：

:This study was aimed at testing the hypothesis that epidermal growth factor (EGF) can modulate the gonadotropin-dependent differentiation of theca-interstitial cells in vitro. Addition of EGF to chemically defined culture medium severely antagonized the ability of hCG to transform undifferentiated theca-interstitial cells into active androgen-producing cells. The inhibitory action of EGF was dose-dependent, hormone-specific, and independent of granulosa cells. Since ovarian androgens are obligatory precursors to estrogen formation and induce atresia, a repressive action of EGF on theca-interstitial cytodifferentiation has new implications for understanding the way in which follicles develop in the ovary.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Erickson GF,Case E

doi

10.1016/0303-7207(83)90031-x

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

71-6

issue

1

eissn

0303-7207

issn

1872-8057

journal_volume

31

pub_type

杂志文章

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