Ghrelin in eating disorders.

abstract：:Protein biosynthesis in neurointermediate lobes of mouse pituitaries was investigated using pulse and pulse-chase techniques with [3H]lysine. Electrophoretic analysis of lobe homogenates on acid-urea gels resolved 11 labeled products. One was a large protein which was rapidly synthesized during pulse-incubations and d...

journal_title：Molecular and cellular endocrinology

authors： Jenks BG,Meulepas WJ,Soons PJ,van Overbeeke AP

更新日期：1979-02-01 00:00:00

abstract：:Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2). From a patient with clinical and biochemical criteria suggestive with CH associated with IOD, TPO and DUOX2 genes were analyzed by mean...

journal_title：Molecular and cellular endocrinology

authors： Belforte FS,Citterio CE,Testa G,Olcese MC,Sobrero G,Miras MB,Targovnik HM,Rivolta CM

更新日期：2016-01-05 00:00:00

abstract：:17Beta hydroxysteroid dehydrogenase type 7 (HSD17B7) was described to possess dual functionality in steroidogenesis as well as in postsqualene cholesterol biosynthesis in vitro. In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the...

journal_title：Molecular and cellular endocrinology

authors： Ohnesorg T,Adamski J

更新日期：2006-03-27 00:00:00

abstract：:This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse mammary gland that has been used extensively as an experimental model. Studies have led to the concept that progesterone controls proliferation and morphogenesis of the luminal epithelium in a tightly orchestrated manner at distinc...

journal_title：Molecular and cellular endocrinology

authors： Obr AE,Edwards DP

更新日期：2012-06-24 00:00:00

abstract：:Desethylamiodarone (DEA), the major metabolite of the potent antiarrythmic drug amiodarone, is a non-competitive inhibitor of the binding of thyroid hormone (T3) to the beta 1-thyroid hormone receptor (T3R). In the present study, we investigated whether DEA acts in a similar way with respect to the alpha 1-T3R. The ch...

journal_title：Molecular and cellular endocrinology

authors： van Beeren HC,Bakker O,Wiersinga WM

更新日期：1995-07-01 00:00:00

abstract：:Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex. In control guinea pigs, a number of morphologic differences distinguished the ZF from the ZR, including the presence of far m...

journal_title：Molecular and cellular endocrinology

authors： Yuan BB,Tchao R,Funae Y,Voigt JM,Colby HD

更新日期：1998-11-25 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D(3)), the active metabolite of vitamin D(3), inhibits breast cancer cell growth in vivo and in vitro. To examine mechanisms of 1,25D(3) induced growth arrest and apoptosis, cell lines were established from DMBA induced mammary tumors derived from vitamin D(3) receptor knockout (VDRKO) ...

journal_title：Molecular and cellular endocrinology

authors： Zinser GM,McEleney K,Welsh J

更新日期：2003-02-28 00:00:00

abstract：:The expression of Kiss1 in the anteroventral periventricular nucleus (AVPV) and its product, metastin/kisspeptin, show a circadian pattern with a peak in the evening, which shows a strong phase relationship with the time of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) surge in rodents. Here we re...

journal_title：Molecular and cellular endocrinology

authors： Xu Z,Kaga S,Tsubomizu J,Fujisaki J,Mochiduki A,Sakai T,Tsukamura H,Maeda K,Inoue K,Adachi AA

更新日期：2011-06-06 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

journal_title：Molecular and cellular endocrinology

authors： Patel KV,Schrey MP

更新日期：1992-06-01 00:00:00

abstract：:The diterpene forskolin was found to activate the adenylate cyclase system in intact tissue and membrane preparations of the immature rat ovary. The cyclic AMP (cAMP) response reached a maximal level after 5 min and no decline was observed even after 4 h of incubation. Forskolin stimulated production of both progester...

journal_title：Molecular and cellular endocrinology

authors： Hedin L,Rosberg S

更新日期：1983-11-01 00:00:00

abstract：:We have identified a specific LHR mRNA binding protein that selectively binds to the polypyrimidine-rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. This process has been shown to be one of the mechanisms that is responsible for the loss of the steady-state levels of LHR mR...

journal_title：Molecular and cellular endocrinology

authors： Menon KM,Menon B,Wang L,Gulappa T,Harada M

更新日期：2010-11-25 00:00:00

abstract：:The transcriptional activity of various lengths of the 5'-untranslated region (UTR) of the murine LH receptor (R) gene were studied using the luciferase reporter gene in transiently transfected mouse Leydig tumor cells (mLTC-1). Chinese hamster ovarian (CHO) and HeLa cells were used as controls. The basal transcriptio...

journal_title：Molecular and cellular endocrinology

authors： El-Hefnawy T,Krawczyk Z,Nikula H,Viherä I,Huhtaniemi I

更新日期：1996-05-31 00:00:00

abstract：:Overexpression of the X-linked inhibitor of apoptosis (XIAP) prevents islet allograft rejection. We constructed an adeno-associated virus expressing XIAP driven by the rat insulin promoter (dsAAV8-RIP-XIAP) for long-term beta-cell gene expression in vivo. Pancreatic delivery of dsAAV8-RIP-XIAP prevented autoimmune dia...

journal_title：Molecular and cellular endocrinology

authors： Obach M,Hosseini-Tabatabaei A,Montane J,Wind K,Soukhatcheva G,Dai D,Priatel JJ,Orban PC,Verchere CB

更新日期：2018-12-05 00:00:00

abstract：:The cellular content of preuteroglobin mRNA in endometrium was measured by molecular hybridization to preuteroglobin cDNA, and compared with uteroglobin content in the uterine secretion as determined by radioimmunoassay. The following results were obtained. (1) A single injection of either estradiol or progesterone le...

journal_title：Molecular and cellular endocrinology

authors： Heins B,Beato M

更新日期：1981-02-01 00:00:00

abstract：:Wilms' tumour is a childhood kidney cancer, and a classic example of cancer arising through disrupted development (Armstrong et al., 1992). It is one of the most common solid paediatric malignancies, affecting one in 10000 children. The genetics of Wilms' tumour is complicated, with several different genes or chromoso...

journal_title：Molecular and cellular endocrinology

authors： Schedl A,Hastie N

更新日期：1998-05-25 00:00:00

abstract：:This study was aimed to improve knowledge about swine ovarian follicular function, paying attention to angiogenesis, since new vessel growth is a fundamental event in ovarian function. In particular, we investigated a potential involvement of netrin-1, a protein known as a guidance axon factor. Firstly, we studied the...

journal_title：Molecular and cellular endocrinology

authors： Basini G,Cortimiglia C,Baioni L,Bussolati S,Grolli S,Ramoni R,Grasselli F

更新日期：2011-01-01 00:00:00

abstract：:The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes. Important in this relationship is the strong correlation between hyperinsulinemia and low levels of albuminuria (e.g. microalbuminuria). Recent work highl...

journal_title：Molecular and cellular endocrinology

authors： Nistala R,Whaley-Connell A

更新日期：2013-09-25 00:00:00

abstract：:Mutations of SRY are the cause of 46,XY complete pure gonadal dysgenesis (PGD) in 10-15% of patients. In this study, DNA was isolated and sequenced from blood leukocytes and from paraffin-embedded gonadal tissue in five patients with 46,XY complete PGD. DNA binding capability was analyzed by three different methods. T...

journal_title：Molecular and cellular endocrinology

authors： Sánchez-Moreno I,Canto P,Munguía P,de León MB,Cisneros B,Vilchis F,Reyes E,Méndez JP

更新日期：2009-02-27 00:00:00

abstract：:Isolated islets were either studied immediately after isolation (fresh; F), or were cultured for 6 days at 11 mM glucose (desensitized; D), or were incubated for 2 h at 5.5 mM glucose following D (recovered; R). Glucose-stimulated insulin secretion in D islets was reduced compared with F and R islets. In the presence ...

journal_title：Molecular and cellular endocrinology

authors： Laychock SG

更新日期：1995-08-30 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine involved in autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease. IL-6 is produced by infiltrating immune cells and by thyrocytes. In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1), thyroid-stimulating ...

journal_title：Molecular and cellular endocrinology

authors： Szabo-Fresnais N,Blondeau JP,Pomérance M

更新日期：2008-03-12 00:00:00

abstract：:Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated d-glucose that Akt1 and the post-translational modif...

journal_title：Molecular and cellular endocrinology

authors： Hou J,Chong ZZ,Shang YC,Maiese K

更新日期：2010-06-10 00:00:00

abstract：:Previous studies have indicated that following nutrient ingestion, GIP is released principally from the upper small intestine. In addition to its presence in the rat small intestine, GIP transcripts have also been localized to the submandibular salivary gland (SSG). The present studies were directed to further charact...

journal_title：Molecular and cellular endocrinology

authors： Tseng CC,Boylan MO,Jarboe LA,Williams EK,Sunday ME,Wolfe MM

更新日期：1995-11-30 00:00:00

abstract：:It has already been shown that Wistar rat thyroid (WRT) cells in low concentrations of calf serum (0.5%) are under the influence of both thyrotropin (TSH) and insulin as regards growth. The present data show that epidermal growth factor (EGF), in concentrations up to 10 micrograms/ml, is not able to modify DNA synthes...

journal_title：Molecular and cellular endocrinology

authors： Rotella CM,Mavilia C,Frediani U,Toccafondi R

更新日期：1989-08-01 00:00:00

abstract：:The synthesis and phosphorylation of H1 histones were studied in organ cultures of midpregnant mouse mammary glands exposed to various combinations of insulin, cortisol and prolactin over a 48-h period. The synthesis of specific H1 histone subtypes was changed only when all three hormones were present, and the effect ...

journal_title：Molecular and cellular endocrinology

authors： Hohmann P,Hughes C

更新日期：1987-11-01 00:00:00

abstract：:Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of An...

journal_title：Molecular and cellular endocrinology

authors： Gowrisankar YV,Clark MA

更新日期：2016-12-05 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) initiates infection when the envelope protein, gp52, binds to a cell surface protein and triggers internalization. The hormonal regulation of this protein was studied both in vitro and in vivo. In mammary gland explant culture, levels of the MMTV binding protein were maintained onl...

journal_title：Molecular and cellular endocrinology

authors： Bolander FF Jr

更新日期：1991-12-01 00:00:00

abstract：:Neonatal and adult rat islets, cultured for 7-9 days in the presence of 10.5 mM D-glucose, were incubated for 120 min with either D-glucose (2.8 and 16.7 mM) or L-leucine (1.0 and 20.0 mM). The total and anaerobic rates of glycolysis, as judged respectively through the generation of 3H2O from D-[5-3H]glucose and 14C-l...

journal_title：Molecular and cellular endocrinology

authors： Boschero AC,Bordin S,Sener A,Malaisse WJ

更新日期：1990-10-01 00:00:00

abstract：:The metabolism of radioactive testosterone, 5alpha-dihydrotestosterone, 4-androstene-3beta,17beta-diol or 4-androstene-3alpha,17beta-diol by the human cell line NHIK 3025, derived from a carcinoma of the uterine cervix, was studied. The cells were grown in Eagle's minimal essential medium (MEM) with a steriod concentr...

journal_title：Molecular and cellular endocrinology

authors： Stenstad P,Ostgaard K,Eik-nes KB

更新日期：1977-10-01 00:00:00

abstract：:In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric cAMP-responsive luciferase so that real-time variations of intracellular cAMP concentration could be followed using oxiluciferin luminescence produced from cat...

journal_title：Molecular and cellular endocrinology

authors： Klett D,Meslin P,Relav L,Nguyen TM,Mariot J,Jégot G,Cahoreau C,Combarnous Y

更新日期：2016-10-15 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00