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Multiple roles for the Wilms' tumour suppressor gene, WT1 in genitourinary development.

Abstract：

:Wilms' tumour is a childhood kidney cancer, and a classic example of cancer arising through disrupted development (Armstrong et al., 1992). It is one of the most common solid paediatric malignancies, affecting one in 10000 children. The genetics of Wilms' tumour is complicated, with several different genes or chromosomal regions being implicated (Armstrong et al., 1992). However, the gene we know most about is the Wilms' tumour predisposition gene, WT1 (Bickmore et al., 1992; Bruening and Pelletier, 1996). It is now clear that mutations in this gene in humans can lead to abnormalities of the kidneys and gonads, as well as to the eponymous tumour. Also, as discussed below, WT1 is essential for kidney, testis and ovary development, as revealed in knockout mice.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Schedl A,Hastie N

doi

10.1016/s0303-7207(98)00031-8

subject

Has Abstract

pub_date

1998-05-25 00:00:00

pages

65-9

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(98)00031-8

journal_volume

140

pub_type

杂志文章,评审

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