Interaction of indomethacin with the antilipolytic effect of prostaglandin E2 in rat adipocytes.

abstract：:Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesi...

journal_title：Molecular and cellular endocrinology

authors： Louw-du Toit R,Storbeck KH,Cartwright M,Cabral A,Africander D

更新日期：2017-02-05 00:00:00

abstract：:It has already been shown that Wistar rat thyroid (WRT) cells in low concentrations of calf serum (0.5%) are under the influence of both thyrotropin (TSH) and insulin as regards growth. The present data show that epidermal growth factor (EGF), in concentrations up to 10 micrograms/ml, is not able to modify DNA synthes...

journal_title：Molecular and cellular endocrinology

authors： Rotella CM,Mavilia C,Frediani U,Toccafondi R

更新日期：1989-08-01 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:Deficiency of adrenal hormones promotes exacerbated neutrophil influx into inflammatory sites. We investigated the effect of adrenal deficiency on neutrophil mobilization comparing adrenalectomized (ADX) male Wistar rats to sham-operated (SO) or non-manipulated (N) animals, as controls. Seven days after surgeries, the...

journal_title：Molecular and cellular endocrinology

authors： Cavalcanti DM,Lotufo CM,Borelli P,Tavassi AM,Pereira AL,Markus RP,Farsky SH

更新日期：2006-04-25 00:00:00

abstract：:The metabolism of radioactive testosterone, 5alpha-dihydrotestosterone, 4-androstene-3beta,17beta-diol or 4-androstene-3alpha,17beta-diol by the human cell line NHIK 3025, derived from a carcinoma of the uterine cervix, was studied. The cells were grown in Eagle's minimal essential medium (MEM) with a steriod concentr...

journal_title：Molecular and cellular endocrinology

authors： Stenstad P,Ostgaard K,Eik-nes KB

更新日期：1977-10-01 00:00:00

abstract：:A comparative study of hGH and IL2 post-signaling effects, as examined by RNA expression (Nb29) and protein levels of the heat-shock protein hsp70, was performed in a hormone-dependent rat lymphoma cell line, Nb2-11C. Optimal doses of hGH or IL2 increased Nb29 expression in a dose-dependent manner. Addition of both mi...

journal_title：Molecular and cellular endocrinology

authors： Horn S,Cohen R,Gertler A

更新日期：1994-11-01 00:00:00

abstract：:We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deac...

journal_title：Molecular and cellular endocrinology

authors： Tao RH,Kawate H,Wu Y,Ohnaka K,Ishizuka M,Inoue A,Hagiwara H,Takayanagi R

更新日期：2006-03-09 00:00:00

abstract：:The function of the major adrenal steroid dehydroepiandrosterone (DHEA) is not known. It has been reported to improve learning and memory in mice and can exert neuroprotective and trophic effects, particularly in the hippocampus. We recently described a cytochrome P450 (Cyp7b), that catalyses the 7alpha-hydroxylation ...

journal_title：Molecular and cellular endocrinology

authors： Bean R,Seckl JR,Lathe R,Martin C

更新日期：2001-03-28 00:00:00

abstract：:Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. GWAS, however, are by nature gene agnostic, and SNPs reaching the appropriate statistical threshold for a given phenotype can appear a...

journal_title：Molecular and cellular endocrinology

authors： Yeo GS

更新日期：2014-11-01 00:00:00

abstract：:An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offsprin...

journal_title：Molecular and cellular endocrinology

authors： Zhao M,Yuan L,Yuan MM,Huang LL,Su C,Chen YH,Yang YY,Hu Y,Xu DX

更新日期：2018-10-15 00:00:00

abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

journal_title：Molecular and cellular endocrinology

authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

更新日期：2012-10-15 00:00:00

abstract：:Testes from rats of different maturational ages were explored for presence of paracrine sertoli cell growth factors. Pubertal and adult testes contained a 17 kDa protein, with potent stimulatory effect on immature Sertoli cell multiplication in vitro. The bioactivity of this protein was mimicked by rat interleukin-1 (...

journal_title：Molecular and cellular endocrinology

authors： Petersen C,Boitani C,Fröysa B,Söder O

更新日期：2002-01-15 00:00:00

abstract：:Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G(1)-S phase cell cycle progression. We investigated this cooperativity by evaluating if the key cell cycle regulators, c-Myc and cyclin D1, represent points of conv...

journal_title：Molecular and cellular endocrinology

authors： Mawson A,Lai A,Carroll JS,Sergio CM,Mitchell CJ,Sarcevic B

更新日期：2005-01-14 00:00:00

abstract：:A new strain, named WRT cells, has been generated from primary cultures of rat thyroids. The primary culture was grown in Coon's modified Ham's F12 medium with 5% calf serum, insulin, hydrocortisone, transferrin, somatostatin, glycyl-L-histidyl-L-lysine and thyrotropin (TSH). On the basis of the following facts, the W...

journal_title：Molecular and cellular endocrinology

authors： Brandi ML,Rotella CM,Mavilia C,Franceschelli F,Tanini A,Toccafondi R

更新日期：1987-11-01 00:00:00

abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

journal_title：Molecular and cellular endocrinology

authors： Kurosu H,Kuro-O M

更新日期：2009-02-05 00:00:00

abstract：:Administration of hydrocortisone to adrenalectomised rats elevated levels of both free and membrane-bound polysomes in liver and led to marked shifts in their sedimentation profiles in favour of heavier polysomes. The rate of nascent polypeptide formation was also found to be enhanced in response to the hormone but th...

journal_title：Molecular and cellular endocrinology

authors： Kulkarni SB,Netrawali MS,Pradhan DS,Sreenivasan A

更新日期：1976-02-01 00:00:00

abstract：:Inhibin is a member of the TGF-beta superfamily of growth and differentiation factors and a tumor suppressor. Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of heterozygosity (LOH) as well as dow...

journal_title：Molecular and cellular endocrinology

authors： Risbridger GP,Ball EM,Wang H,Mellor SL,Peehl DM

更新日期：2004-10-15 00:00:00

abstract：:Using primary cultures of porcine Sertoli cells as a model, the effects of ovine prolactin (oPRL) on Sertoli cell function were investigated through FSH binding. PRL treatment (0.3-5 ng/ml) induced a dose-dependent increase (ED50 = 5.10(-11) M) of 125I-FSH binding to Sertoli cells to a maximal stimulation (about 2.5-f...

journal_title：Molecular and cellular endocrinology

authors： Guillaumot P,Tabone E,Benahmed M

更新日期：1996-09-18 00:00:00

abstract：:The Cre-loxP system combined with gene targeting strategies has proven to be very useful for gene inactivation in specific tissues and/or cell types. To achieve adrenal cortex specific recombination in vivo, we used a 0.5-kb fragment of the 5'-flanking region of the akr1b7 gene to drive Cre expression in adrenocortica...

journal_title：Molecular and cellular endocrinology

authors： Lambert-Langlais S,Val P,Guyot S,Ragazzon B,Sahut-Barnola I,De Haze A,Lefrançois-Martinez AM,Martinez A

更新日期：2009-03-05 00:00:00

abstract：:NPY receptors represent novel molecular therapeutic targets in cancer and obesity. However, the extent of NPY receptor expression in normal human tissues is poorly investigated. Based on the role of NPY in reproductive functions, the NPY receptor expression was studied in 25 normal human testes and, additionally, 24 t...

journal_title：Molecular and cellular endocrinology

authors： Körner M,Waser B,Thalmann GN,Reubii JC

更新日期：2011-04-30 00:00:00

abstract：:To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

journal_title：Molecular and cellular endocrinology

authors： Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

更新日期：2013-01-30 00:00:00

abstract：:An enzyme system capable of monodeiodinating T4 to T3 and to rT3 in a microsomal fraction of normal human thyroid tissue is characterized. The pH optimum for 5'-monodeiodination of T4 to T3 was around 7.0 The Km (apparent) for the conversion of T4 to T3 was 5.7 mumoles/l. PTU, ipodate and rT3 inhibited T4 deiodination...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P

更新日期：1984-10-01 00:00:00

abstract：:Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2). From a patient with clinical and biochemical criteria suggestive with CH associated with IOD, TPO and DUOX2 genes were analyzed by mean...

journal_title：Molecular and cellular endocrinology

authors： Belforte FS,Citterio CE,Testa G,Olcese MC,Sobrero G,Miras MB,Targovnik HM,Rivolta CM

更新日期：2016-01-05 00:00:00

abstract：:The congenital adrenal hyperplasias (CAH) are a group of genetic defects in cortisol biosynthesis, most commonly steroid 21-hydroxylase deficiency (21OHD). With the advent of cortisone therapy in the 1960s and newborn screening in the 1990s, most children with 21OHD now reach adulthood. The needs and concerns of adult...

journal_title：Molecular and cellular endocrinology

authors： Auchus RJ

更新日期：2015-06-15 00:00:00

abstract：:The effect of a gonadotropin-releasing hormone-agonist (GnRH-a) on the synthesis of insulin-like growth factor-binding protein-5 (IGFBP-5), a physiological marker for atresia, was investigated. Granulosa cells obtained from diethylstilbestrol (DES)-treated immature female rats were cultured in serum-free medium for 72...

journal_title：Molecular and cellular endocrinology

authors： Onoda N,Li D,Mickey G,Erickson G,Shimasaki S

更新日期：1995-04-28 00:00:00

abstract：:This report represents the joint efforts of three laboratories, one with a primary interest in understanding regulatory processes in the epididymal epithelium (TTT) and two with a primary interest in identifying and characterizing new contraceptive targets (DSJ and SAJ). We have developed a highly refined mouse epidid...

journal_title：Molecular and cellular endocrinology

authors： Turner TT,Johnston DS,Jelinsky SA

更新日期：2006-05-16 00:00:00

abstract：:The autoregulation of prolactin (PRL) secretion in the rat has been demonstrated at both the hypothalamus and the pituitary levels. Studies on the direct negative feedback effect of PRL in the lactotrophs have concentrated on the acute effect on PRL secretion which does not involve change in PRL synthesis. In this stu...

journal_title：Molecular and cellular endocrinology

authors： Devost D,Boutin JM

更新日期：1999-12-20 00:00:00

abstract：:mRNA differential display polymerase chain reaction analysis was used to screen systematically for novel androgen-regulated genes in the human prostatic adenocarcinoma cell line LNCaP. A 232 bp PCR fragment was found to be consistently down-regulated by the synthetic androgen R1881. Sequencing revealed complete identi...

journal_title：Molecular and cellular endocrinology

authors： Ulrix W,Swinnen JV,Heyns W,Verhoeven G

更新日期：1999-09-10 00:00:00

abstract：CONTEXT:Hyperandrogenic states and obesity in women are associated with insulin-resistance. Androgens reduce glucose uptake in adipose cells and increase TNFα production in peripheral monocytes. Inflammatory cytokines have a known detrimental effect on insulin resistance. The aim of the present study was to explore the...

journal_title：Molecular and cellular endocrinology

authors： Crisosto N,Flores C,Maliqueo M,Echiburú B,Vásquez J,Maluenda F,Sir-Petermann T

更新日期：2017-03-15 00:00:00

abstract：:Inflammation causes male hypogonadism. Several inflammatory cytokines, including interleukin 6 (IL-6), are released into the blood and may suppress Leydig cell development. The objective of the present study was to investigate whether IL-6 affected the proliferation and differentiation of rat stem Leydig cells. Leydig...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Chen L,Xie L,Li L,Li X,Li H,Liu J,Chen X,Mao B,Song T,Lian Q,Ge RS

更新日期：2018-09-05 00:00:00