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High expression of NPY receptors in the human testis.

Abstract：

:NPY receptors represent novel molecular therapeutic targets in cancer and obesity. However, the extent of NPY receptor expression in normal human tissues is poorly investigated. Based on the role of NPY in reproductive functions, the NPY receptor expression was studied in 25 normal human testes and, additionally, 24 testicular tumors using NPY receptor autoradiography. In the normal testis, Leydig cells strongly expressed NPY receptor subtype Y2, and small arterial blood vessels Y1. Y2 receptors were found to be functional with agonist-stimulated [(35)S]GTPγS binding autoradiography. Full functional integrity of the NPY system was further suggested by the immunohistochemical detection of NPY peptide in nerve fibers directly adjacent to Leydig cells and arteries. Germ cell tumors expressed Y1 and Y2 on tumor cells in 33% and Y1 on intratumoral blood vessels in 50%. Based on its strong NPY receptor expression in Leydig cells and blood vessels, the normal human testis represents a potentially important physiological and pharmalogical NPY target.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Körner M,Waser B,Thalmann GN,Reubii JC

doi

10.1016/j.mce.2011.01.021

subject

Has Abstract

pub_date

2011-04-30 00:00:00

pages

62-70

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(11)00057-8

journal_volume

337

pub_type

杂志文章

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