Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2.

abstract：:Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid-binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-deple...

journal_title：Molecular and cellular endocrinology

authors： Krautbauer S,Haberl EM,Eisinger K,Pohl R,Rein-Fischboeck L,Rentero C,Alvarez-Guaita A,Enrich C,Grewal T,Buechler C,Neumeier M

更新日期：2017-01-05 00:00:00

abstract：:The role of cannabinoid receptor I (CBR-1) in the induction of decidualization was examined using decidual fibroblasts and human endometrial stromal cells as model systems. Decidual fibroblasts decidualized in vitro for 3 and 6 days in the presence of the CBR-1 agonist R(+)-WIN 55,212-2 mesylate (WIN, 0.1-10 microM) e...

journal_title：Molecular and cellular endocrinology

authors： Moghadam KK,Kessler CA,Schroeder JK,Buckley AR,Brar AK,Handwerger S

更新日期：2005-01-14 00:00:00

abstract：:The interaction between thyroid microsomal autoantibodies and thyroid microsomal antigen/thyroid peroxidase (TPO) has been studied using both intact antigen preparations and their water-soluble trypsin fragments. In an analysis of sera from 30 patients with Graves' or Hashimoto's diseases, microsomal antibodies showed...

journal_title：Molecular and cellular endocrinology

authors： Nakajima Y,Howells RD,Pegg C,Jones ED,Smith BR

更新日期：1987-09-01 00:00:00

abstract：:Type I pseudohypoaldosteronism (PHA1) is a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting and failure to thrive. Typical biochemical features include high levels of plasma aldosterone and renin, hyponatremia and hyperkalemia. Different mutations of the human mineralocorticoid re...

journal_title：Molecular and cellular endocrinology

authors： Sartorato P,Khaldi Y,Lapeyraque AL,Armanini D,Kuhnle U,Salomon R,Caprio M,Viengchareun S,Lombès M,Zennaro MC

更新日期：2004-03-31 00:00:00

abstract：:The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: ex...

journal_title：Molecular and cellular endocrinology

authors： Gobinet J,Poujol N,Sultan Ch

更新日期：2002-12-30 00:00:00

abstract：:Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global epidemic has encouraged ongoing research to characterize the mechanisms underlying obesity and its comorbidities. Recent evidence suggests that saturated fatty acids (SFA) in high-fat diets rapidly generate inflammation in the ...

journal_title：Molecular and cellular endocrinology

authors： Tran DQ,Tse EK,Kim MH,Belsham DD

更新日期：2016-12-15 00:00:00

abstract：:The distribution of the steroidogenic acute regulatory protein (StAR) inside thecal and granulosa-lutein cells of human corpus luteum (CL) was assessed by immunoelectron microscopy. We found greater levels of StAR immunolabeling in steroidogenic cells from early- and mid-than in late luteal phase CL and lower levels i...

journal_title：Molecular and cellular endocrinology

authors： Sierralta WD,Kohen P,Castro O,Muñoz A,Strauss JF 3rd,Devoto L

更新日期：2005-10-20 00:00:00

abstract：:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

journal_title：Molecular and cellular endocrinology

authors： Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

更新日期：2015-01-05 00:00:00

abstract：:Expression of the calcitonin (CT)/calcitonin gene related peptide (CGRP) gene and the proopiomelanocortin (POMC) gene has been demonstrated by Northern blot hybridization analysis of RNA extracted from human medullary thyroid carcinoma (MTC), pheochromocytoma and lung carcinoma. CT mRNA in these tumors could not be di...

journal_title：Molecular and cellular endocrinology

authors： Höppener JW,Steenbergh PH,Moonen PJ,Wagenaar SS,Jansz HS,Lips CJ

更新日期：1986-09-01 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00

abstract：:We have investigated protein kinase C (PKC) regulation by 1,25-(OH)2D3 in the rat osteosarcoma cell line ROS 17/2.8 since previous reports have implicated PKC in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression (J. Biol. Chem. 267 (1992) 12562; Endocrinology 136 (1995) 5685). Here we report that 1,2...

journal_title：Molecular and cellular endocrinology

authors： Rivera-Bermúdez MA,Bertics PJ,Albrecht RM,Mosavin R,Mellon WS

更新日期：2002-02-25 00:00:00

abstract：:Incorporation of p-chloromercuribenzene sulphonate (PCMBS) (1mM) in the assay medium for rat hepatic lactogenic receptor produced complete inhibition of binding of [125I]oPRL to the membrane. However, the presence of the thiol-reactive agent produced no effect on the binding of [125I]bGH to rat hepatic somatogenic rec...

journal_title：Molecular and cellular endocrinology

authors： Tsim KW,Cheng CH

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos. METHODS:The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched bl...

journal_title：Molecular and cellular endocrinology

authors： Sato N,Kawamura K,Fukuda J,Honda Y,Sato T,Tanikawa H,Kodama H,Tanaka T

更新日期：2003-04-28 00:00:00

abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

journal_title：Molecular and cellular endocrinology

authors： Lewy H,Ashkenazi IE,Naor Z

更新日期：2003-05-30 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant e...

journal_title：Molecular and cellular endocrinology

authors： Breitling R,Krazeisen A,Möller G,Adamski J

更新日期：2001-01-22 00:00:00

abstract：:Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative association with human diseases makes them promising pharmacological targets because of the large potential to develop ligands. LXR are mainly considered as intracellular cholesterol "sensors" whose a...

journal_title：Molecular and cellular endocrinology

authors： Viennois E,Mouzat K,Dufour J,Morel L,Lobaccaro JM,Baron S

更新日期：2012-04-04 00:00:00

abstract：:A rapid and sensitive assay of iodothyronine-5'-monodeiodinase (5'-D) was developed using Sephadex column chromatography for separation of substrate 125I-rT3 from the product free 125I-. The distribution of 5'-D activity on rat kidney cortex cell membranes was examined in isopycnic zonal centrifugation experiments usi...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P,Jørgensen PL

更新日期：1988-03-01 00:00:00

abstract：:The ovarian granulosa cell has previously been shown to be a site of insulin-like growth factor (IGF) I production, reception, and action. It is the objective of this study to characterize in greater detail the soluble IGF binding activity released by this cell type. To this end, use was made of granulosa cells from i...

journal_title：Molecular and cellular endocrinology

authors： Adashi EY,Resnick CE,Hernandez ER,Hurwitz A,Rosenfeld RG

更新日期：1990-12-21 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a main factor promoting neovascularization (angiogenesis) of solid tumours as prostate carcinoma. Hypoxia stimulates VEGF gene expression by activating the hypoxia-inducible factor-1 (HIF-1alpha). In the present study, the hypoxia-mimicking agent Ni(2+) induced vasoactive i...

journal_title：Molecular and cellular endocrinology

authors： Collado B,Sánchez-Chapado M,Prieto JC,Carmena MJ

更新日期：2006-04-25 00:00:00

abstract：:The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) are involved in the last step of the biosynthesis of sex steroids from cholesterol. This family of steroidogenic enzymes constitutes an interesting target in the control of the concentration of estrogens and androgens. Among the isoforms of 17beta-HSD, type II pre...

journal_title：Molecular and cellular endocrinology

authors： Poirier D,Bydal P,Tremblay MR,Sam KM,Luu-The V

更新日期：2001-01-22 00:00:00

abstract：:In order to define the possible involvement of proteoglycans (PG) in the regulation of Sertoli cell functions, we have examined the effect of para-nitrophenyl-beta-D-xyloside (PNPX), a specific inhibitor of PG synthesis, on follicle stimulating hormone (FSH)-dependent estradiol production by immature rat Sertoli cells...

journal_title：Molecular and cellular endocrinology

authors： Phamantu NT,Bonnamy PJ,Bouakka M,Bocquet J

更新日期：1995-03-01 00:00:00

abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

journal_title：Molecular and cellular endocrinology

authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

更新日期：1999-11-25 00:00:00

abstract：:To fully evaluate the advantages of a cryopreservation program a method needs to be established to express the additional patients pregnant from cryopreservation. The patient specific method considers cryopreservation as augmentation only among patients without a pregnancy from the fresh transfer, or from previously t...

journal_title：Molecular and cellular endocrinology

authors： Schnorr JA,Muasher SJ,Jones HW Jr

更新日期：2000-11-27 00:00:00

abstract：:Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-linked immunosorbent as...

journal_title：Molecular and cellular endocrinology

authors： Hockl P,Sorianello E,Chamson-Reig A,Ballerini G,Campo S,Groome N,Lux-Lantos V,Libertun C

更新日期：2003-05-30 00:00:00

abstract：:Cells isolated enzymically from seminal vesicles and epididymides of normal and castrated rats were shown by electron microscopy to be intact and representative of the tissue. The cells synthesize and secrete tissue-specific proteins. Short-term incorporation of [3H]uridine and [35S]methionine was measured to determin...

journal_title：Molecular and cellular endocrinology

authors： Higgins SJ,Brooks DE,Fuller FM

更新日期：1981-08-01 00:00:00

abstract：:Transthyretin (TTR) is a plasma thyroid hormone (TH) binder that emerged from an ancient hydroxyisourate hydrolase by gene duplication. To know how an ancient TTR had high affinity for THs, molecular and TH binding properties of lamprey TTRs were investigated. In adult serum, the lipoprotein LAL was a major T3 binder ...

journal_title：Molecular and cellular endocrinology

authors： Kasai K,Nishiyama N,Yamauchi K

更新日期：2018-10-15 00:00:00

abstract：:Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events. To determine whether calcium or DREAM may play a role in linking these processes, we used an L-type Ca(2+)-blocker (nimodipine) and found that not only GnRH gene expression (GnRH-GE) pulse act...

journal_title：Molecular and cellular endocrinology

authors： Leclerc GM,Boockfor FR

更新日期：2007-03-15 00:00:00

abstract：:This study describes a model for short-term culture of intact mouse follicles under serum-free conditions. Follicles were either obtained from immature mice receiving no ovarian stimulation (i.e. no eCG-primed protocol, group I) or from mice undergoing ovarian stimulation (i.e. eCG-primed protocol, group II). Follicle...

journal_title：Molecular and cellular endocrinology

authors： Xie H,Xia G,Byskov AG,Andersen CY,Bo S,Tao Y

更新日期：2004-04-15 00:00:00

abstract：:The oligosaccharide chains of pituitary glycoprotein hormones such as human thyroid-stimulating hormone (hTSH) have been shown to be important in biosynthesis, subunit association, secretion and bioactivity. However, the exact biological significance of these glycosylation variants (isoforms) remains controversial. Th...

journal_title：Molecular and cellular endocrinology

authors： Schaaf L,Leiprecht A,Saji M,Hübner U,Usadel KH,Kohn LD

更新日期：1997-09-19 00:00:00

abstract：:The high mobility group AT-hook (HMGA) proteins, a family of DNA architectural factors, are highly expressed during embryogenesis and play a crucial role in several different biological processes, as well as in tumorigenesis of a wide range of tissues, including pituitary. Indeed, HMGA2 has been found rearranged and a...

journal_title：Molecular and cellular endocrinology

authors： Fedele M,Palmieri D,Fusco A

更新日期：2010-09-15 00:00:00