Abstract:
:Expression of the calcitonin (CT)/calcitonin gene related peptide (CGRP) gene and the proopiomelanocortin (POMC) gene has been demonstrated by Northern blot hybridization analysis of RNA extracted from human medullary thyroid carcinoma (MTC), pheochromocytoma and lung carcinoma. CT mRNA in these tumors could not be distinguished in size from CT mRNA isolated from normal human thyroid tissue. CGRP mRNA (previously demonstrated in 12 out of 12 lung tumor cell lines investigated) could not be detected in 13 primary lung tumors or 10 metastases thereof. The length of POMC mRNA in MTCs (present in all 4 metastases investigated but not in 7 primary tumors) and pheochromocytomas is about 100 nucleotides more than pituitary POMC RNA. In lung tumors 2 POMC RNA species can be detected, one of the same size as in pituitary tissue and one about 100 nucleotides larger.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Höppener JW,Steenbergh PH,Moonen PJ,Wagenaar SS,Jansz HS,Lips CJdoi
10.1016/0303-7207(86)90023-7subject
Has Abstractpub_date
1986-09-01 00:00:00pages
125-30issue
1-2eissn
0303-7207issn
1872-8057pii
0303-7207(86)90023-7journal_volume
47pub_type
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