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Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

Abstract：

:The anterior pituitary gland is a key organ involved in the control of multiple physiological functions including growth, reproduction, metabolism and stress. These functions are controlled by five distinct hormone-producing pituitary cell types that produce growth hormone (somatotropes), prolactin (lactotropes), adrenocorticotropin (corticotropes), thyrotropin (thyrotropes) and follicle stimulating hormone/luteinizing hormone (gonadotropes). Classically, the synthesis and release of pituitary hormones was thought to be primarily regulated by central (neuroendocrine) signals. However, it is now becoming apparent that factors produced by pituitary hormone targets (endocrine and non-endocrine organs) can feedback directly to the pituitary to adjust pituitary hormone synthesis and release. Therefore, pituitary cells serve as sensors to integrate central and peripheral signals in order to fine-tune whole-body homeostasis, although it is clear that pituitary cell regulation is species-, age- and sex-dependent. The purpose of this review is to provide a comprehensive, general overview of our current knowledge of both central and peripheral regulators of pituitary cell function and associated intracellular mechanisms, focusing on human and non-human primates.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Vázquez-Borrego MC,Gahete MD,Martínez-Fuentes AJ,Fuentes-Fayos AC,Castaño JP,Kineman RD,Luque RM

doi

10.1016/j.mce.2017.12.007

subject

Has Abstract

pub_date

2018-03-05 00:00:00

pages

4-22

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30635-4

journal_volume

463

pub_type

杂志文章,评审

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