当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90.

Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90.

Abstract：

:Heat shock protein 90 (Hsp90) has been demonstrated in both cytoplasm and nucleus, and regulates cytoplasmic retention of glucocorticoid receptor (GR). However, the role of nuclear Hsp90 in GR trafficking is less characterized. The present study examined the role of Hsp90 in nuclear retention of GR after ligand withdrawal. Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486. GA accelerated relocalization of GR in the cytoplasm even when reimport of GR into the nucleus was inhibited by okadaic acid or when novel GR synthesis was inhibited by cycloheximide. Overexpression of wild type or nuclear-targeted Hsp90 attenuated Hsp90 inhibitor-induced acceleration of GR nuclear export, although nuclear Hsp90 showed higher activity than the wild type. Only nuclear-targeted Hsp90 prolonged basal nuclear retention of GR after withdrawal of dexamethasone and corticosterone. These results suggest that nuclear Hsp90 regulates the nuclear retention of GR.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Tago K,Tsukahara F,Naruse M,Yoshioka T,Takano K

doi

10.1016/j.mce.2003.10.057

keywords:

subject

Has Abstract

pub_date

2004-01-15 00:00:00

pages

131-8

issue

2

eissn

0303-7207

issn

1872-8057

pii

S0303720703004258

journal_volume

213

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.

    abstract：:The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.08.009

    authors： Qi H,Grenier J,Fournier A,Labrie C

    更新日期：2003-11-28 00:00:00

  • The actions of forskolin, cholera toxin and iloprost on casein secretion by lactating doe mammary glands.

    abstract：:The secretagogue effects of prolactin (PRL) and of various agents acting on cAMP levels, forskolin, cholera toxin and iloprost (a stable analogue of prostaglandin I2) have been assessed in lactating doe mammary gland fragments in vitro. Forskolin (10 microM), cholera toxin (1 microgram/ml) and iloprost (10 mM) stimula...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90161-5

    authors： Ollivier-Bousquet M

    更新日期：1989-08-01 00:00:00

  • Hormonal regulation of early follicle development in the rat ovary.

    abstract：:Although earlier studies focused on the hormonal regulation of antral and preovulatory follicles, recent studies indicate the importance of the hormonal control mechanism for preantral follicles. The endocrine hormone FSH is not only a survival factor for early antral follicles but also a potent growth and differentia...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(99)00245-2

    authors： Hsueh AJ,McGee EA,Hayashi M,Hsu SY

    更新日期：2000-05-25 00:00:00

  • Specific DNA binding and transactivation potential of recombinant, purified Stat5.

    abstract：:The signal transducers and activators of transcriptions (Stats) are central mediators of cytokine responses especially in hematopoietic cells. The detailed molecular mechanisms of Stat activation, particularly the role of post-translational modifications and co-operation with cellular transcription factors are subject...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00588-3

    authors： Beisenherz-Huss C,Mundt M,Herrala A,Vihko P,Schubert A,Groner B

    更新日期：2001-10-25 00:00:00

  • The antiproliferative effect of tamoxifen in breast cancer cells: mediation by the estrogen receptor.

    abstract：:The effects of tamoxifen (Tam) and its 4-hydroxylated metabolite (OH-Tam) on the growth of two human breast cancer cell lines ( MCF7 and BT20 ) were evaluated by fluorometric DNA assay. The effects of the antiestrogens were dependent upon their concentrations and the nature of the cells. At concentrations below 4 micr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90004-2

    authors： Bardon S,Vignon F,Derocq D,Rochefort H

    更新日期：1984-05-01 00:00:00

  • Fourier analysis of differential light scattering for the quantitation of FSH response associated with structural changes in immortalized granulosa cells.

    abstract：:We have established granulosa cell lines which express constitutively the rat FSH receptors by cotransfection of primary granulosa cells obtained from preovulatory follicles with SV40 DNA, Ha-ras oncogene and a plasmid expressing FSH receptors. These cells respond specifically to ovine and human FSH by cell rounding, ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03774-4

    authors： Schiffer Z,Keren-Tal I,Deutsch M,Dantes A,Aharoni D,Weinerb A,Tirosh R,Amsterdam A

    更新日期：1996-04-19 00:00:00

  • Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro.

    abstract：:We have previously shown that the tyrosine kinase receptor Flk-1 and its ligand, vascular endothelial growth factor (VEGF), may play a role in the development of fetal rat islet-like structures in vitro, possibly by stimulating the maturation of endocrine precursor cells in the pancreatic ductal epithelium. In order t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(96)03977-9

    authors： Oberg-Welsh C,Sandler S,Andersson A,Welsh M

    更新日期：1997-02-07 00:00:00

  • KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort.

    abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.03.007

    authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

    更新日期：2016-05-15 00:00:00

  • Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins.

    abstract：:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.08.010

    authors： Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

    更新日期：2015-01-05 00:00:00

  • Estrogen receptor mutations.

    abstract：:The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(98)00170-1

    authors： Taylor JA,Lewis KJ,Lubahn DB

    更新日期：1998-10-25 00:00:00

  • Hypoxia inhibits semicarbazide-sensitive amine oxidase activity in adipocytes.

    abstract：:Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity. We investigated whether in vitro, adipocyte SSAO was mo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.04.011

    authors： Repessé X,Moldes M,Muscat A,Vatier C,Chetrite G,Gille T,Planes C,Filip A,Mercier N,Duranteau J,Fève B

    更新日期：2015-08-15 00:00:00

  • The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains.

    abstract：:The nuclear receptor corepressor (NCoR) interacts with the DNA-bound thyroid receptor (TR) homodimer through two of its three receptor-interacting domains (RIDs). One of these RIDs must be the most N-terminal, termed N3, which preferentially works with the next closest RID, N2. Interestingly, the spacing between the R...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2009.02.028

    authors： Astapova I,Dordek MF,Hollenberg AN

    更新日期：2009-08-13 00:00:00

  • Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

    abstract：:Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western co...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2015.02.018

    authors： Asrih M,Jornayvaz FR

    更新日期：2015-12-15 00:00:00

  • Thyroglobulin gene mutations in Chinese patients with congenital hypothyroidism.

    abstract：:Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism (CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been investigated. Here we conducted a genetic screening of TG gene in a cohort of 382 Chinese CH patients. We identified 22 rare non-polymorphic v...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.01.007

    authors： Hu X,Chen R,Fu C,Fan X,Wang J,Qian J,Yi S,Li C,Luo J,Su J,Zhang S,Xie B,Zheng H,Lai Y,Chen Y,Li H,Gu X,Chen S,Shen Y

    更新日期：2016-03-05 00:00:00

  • Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line.

    abstract：:Differentiation of human placental mononuclear trophoblasts into a multinucleate syncytium involves up-regulation of key proteins promoting cell fusion and increased capacity for placental hormonogenesis. It is well established that the activation of adenylyl cyclase leads to increased expression of trophoblast fusoge...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.10.013

    authors： Delidaki M,Gu M,Hein A,Vatish M,Grammatopoulos DK

    更新日期：2011-01-30 00:00:00

  • Gonadotropin releasing hormone (GnRH) and estradiol (E(2)) regulation of cell cycle in gonadotrophs.

    abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(03)00119-9

    authors： Lewy H,Ashkenazi IE,Naor Z

    更新日期：2003-05-30 00:00:00

  • Chronic restraint stress induces serotonin transporter expression in the rat adrenal glands.

    abstract：:Chronic restraint stress (CRS) magnifies restraint-induced corticosterone secretion through a mechanism involving increased adrenocortical 5-HT content and turnover. We analysed the impact of CRS on serotonin transporter (SERT) expression and distribution in rat adrenal glands. Male Wistar rats were submitted to CRS (...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2020.110935

    authors： Shanker S,Saroj N,Cordova EJ,Jarillo-Luna RA,López-Sánchez P,Terrón JA

    更新日期：2020-12-01 00:00:00

  • Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein.

    abstract：:The LHRH receptor in alpha T3-1 gonadotrope cells was shown to bring about a marked and sustained activation of MAP kinase. This response was prevented by protein kinase C inhibition or down-regulation and could be partially mimicked by phorbol ester. Additional evidence for inhibition of this response by pertussis to...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03616-f

    authors： Sim PJ,Wolbers WB,Mitchell R

    更新日期：1995-08-11 00:00:00

  • Brain sex matters: estrogen in cognition and Alzheimer's disease.

    abstract：:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2013.12.018

    authors： Li R,Cui J,Shen Y

    更新日期：2014-05-25 00:00:00

  • Action of hormone responsive sequence in 2.3 kb promoter of CYP11A1.

    abstract：:The CYP11A1 gene encodes cytochrome P450scc, the enzyme catalyzing the first step of steroid biosynthesis in the adrenal and gonad. We generated transgenic mice containing 2.3 kb of the 5'-flanking region of CYP11A1 driving LacZ reporter gene expression, in order to study hormonal control of CYP11A1 gene expression in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00388-4

    authors： Huang Y,Hu M,Hsu N,Wang CL,Chung B

    更新日期：2001-04-25 00:00:00

  • Molecular action of androgens.

    abstract：:The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: ex...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(02)00364-7

    authors： Gobinet J,Poujol N,Sultan Ch

    更新日期：2002-12-30 00:00:00

  • Ovine 11 beta-hydroxysteroid dehydrogenase type 2 gene predicts a protein distinct from that deduced by the cloned kidney cDNA at the C-terminus.

    abstract：:The gene encoding ovine 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) was cloned and characterized. This gene consists of five exons and is greater than 4 kb in length. It contains an open reading frame of 1215 bp, which encodes a protein of 404 amino acids with a predicted MW of 44 kDa. The deduced ovine...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03775-6

    authors： Campbell LE,Yu M,Yang K

    更新日期：1996-05-17 00:00:00

  • Allelic variation in the hemolymph juvenile hormone binding protein gene of Manduca sexta.

    abstract：:Peripheral distribution of the insect juvenile hormones (JHs) requires hemolymph transport proteins. A comparison of three strains of the tobacco hornworm Manduca sexta indicates that hemolymph JH binding protein (hJHBP) levels in the Madison wild-type (Mwt) strain are significantly higher than in the black larval mut...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(03)00259-4

    authors： Young JK,Orth AP,Goodman WG

    更新日期：2003-10-31 00:00:00

  • Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta.

    abstract：:Evidence that transforming growth factor-beta (TGF beta) is produced by porcine thecal cells and acts upon porcine granulosa cells suggests that this peptide may be a local regulator of follicular function in this species. The objective of the present study was to investigate the effects of TGF beta on steroidogenesis...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90131-o

    authors： Engelhardt H,Tekpetey FR,Gore-Langton RE,Armstrong DT

    更新日期：1992-05-01 00:00:00

  • Receptor-selective determinants in catfish gonadotropin seat-belt loops.

    abstract：:Mammalian gonadotropins are highly selective. Charge differences between the Cys(10-11) sequence of FSHbeta and LHbeta/CGbeta seat-belt loops determine the ability of these hormones to interact with the LH-R. Selective FSH-R binding is mainly dependent on the presence of an FSHbeta-specific sequence between Cys(11-12)...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2004.06.011

    authors： Vischer HF,Marques RB,Granneman JC,Linskens MH,Schulz RW,Bogerd J

    更新日期：2004-09-30 00:00:00

  • Adrenal zonation: clues from 11beta-hydroxylase and aldosterone synthase.

    abstract：:Aldosterone and cortisol are the major mineralocorticoid and glucocorticoid produced by the human adrenal. Circulating levels of angiotensin II and potassium control the adrenal production of aldosterone, while the production of cortisol is controlled mainly by adrenocorticotropin. The capacity of the adrenal cortex t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(99)00051-9

    authors： Rainey WE

    更新日期：1999-05-25 00:00:00

  • Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue.

    abstract：:Dehydroepiandrosterone (DHEA), a precursor sex steroid, circulates in sulphated form (DHEAS). Serum DHEAS concentrations are inversely correlated with metabolic syndrome components and in vivo/in vitro studies suggest a role in modulating adipose mass. To investigate further, we assessed the in vitro biological effect...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.02.017

    authors： Rice SP,Zhang L,Grennan-Jones F,Agarwal N,Lewis MD,Rees DA,Ludgate M

    更新日期：2010-05-14 00:00:00

  • Adrenal deficiency alters mechanisms of neutrophil mobilization.

    abstract：:Deficiency of adrenal hormones promotes exacerbated neutrophil influx into inflammatory sites. We investigated the effect of adrenal deficiency on neutrophil mobilization comparing adrenalectomized (ADX) male Wistar rats to sham-operated (SO) or non-manipulated (N) animals, as controls. Seven days after surgeries, the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.01.007

    authors： Cavalcanti DM,Lotufo CM,Borelli P,Tavassi AM,Pereira AL,Markus RP,Farsky SH

    更新日期：2006-04-25 00:00:00

  • Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.

    abstract：:We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps deliv...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00681-5

    authors： Haberkorn V,Heydel JM,Mounie J,Artur Y,Goudonnet H

    更新日期：2002-04-25 00:00:00

  • o,p'-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells.

    abstract：:Using a combination of in vitro assays we have evaluated whether DDT metabolites can interact with the progesterone receptor pathway in yeast expressing human progesterone receptor (hPR) and in T47D human breast cancer cells which express endogenous hPR. In transactivation assays using both yeast and T47D cells, o,p'-...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(96)04041-5

    authors： Klotz DM,Ladlie BL,Vonier PM,McLachlan JA,Arnold SF

    更新日期：1997-04-25 00:00:00