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Hypoxia inhibits semicarbazide-sensitive amine oxidase activity in adipocytes.

Abstract：

:Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity. We investigated whether in vitro, adipocyte SSAO was modulated under hypoxic conditions that is present in adipose tissue from obese or intensive care unit. Physical or pharmacological hypoxia decreased SSAO activity in murine adipocytes and human adipose tissue explants, while enzyme expression was preserved. This effect was time-, dose-dependent and reversible. This down-regulation was confirmed in vivo in subcutaneous adipose tissue from a rat model of hypoxia. Hypoxia-induced suppression in SSAO activity was independent of the HIF-1-α pathway or of oxidative stress, but was partially antagonized by medium acidification. Hypoxia-induced down-regulation of SSAO activity could represent an adaptive mechanism to lower toxic molecules production, and may thus protect from tissue injury during these harmful conditions.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Repessé X,Moldes M,Muscat A,Vatier C,Chetrite G,Gille T,Planes C,Filip A,Mercier N,Duranteau J,Fève B

doi

10.1016/j.mce.2015.04.011

subject

Has Abstract

pub_date

2015-08-15 00:00:00

pages

58-66

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(15)00197-5

journal_volume

411

pub_type

杂志文章

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