当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Comparison of steroid and LH-RH effects on the responsiveness of hemipituitary glands and dispersed pituitary cells.

Comparison of steroid and LH-RH effects on the responsiveness of hemipituitary glands and dispersed pituitary cells.

Abstract：

:We have carried out further in vitro studies on the priming effect of LH-RH and the effect of steroids on pituitary responsiveness to LH-RH. In hemipituitary glands, the priming effect could be elicited only once within an 11-h period and was found to diminish significantly with time after the first exposure to LH-RH. Incubation with oestradiol-17 beta (E2) had no significant effect on the responsiveness of hemipituitary glands to LH-RH. By contrast, E2 increased the responsiveness of dispersed cell system. The presence of hypothalamus or synthetic LH-RH did not facilitate the effects of E2. Testosterone significantly reduced the spontaneous and LH-RH-induced release of LH while progesterone had no effect. Exposure to E2 alone in either of the systems did not produce a consistent increase in the total amount of LH in the system. Synthesis of LH was, however, stimulated by exposure to LH-RH for 48 h but not 12 h. These results demonstrate that there is a marked difference between the mechanisms by which LH-RH and steroids affect the responsiveness of the anterior pituitary gland to LH-RH.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Speight A,Fink G

doi

10.1016/0303-7207(81)90003-4

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

267-81

issue

3

eissn

0303-7207

issn

1872-8057

journal_volume

24

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Elements involved in the regulation of the StAR gene.

    abstract：:The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(01)00423-3

    authors： Stocco DM,Clark BJ,Reinhart AJ,Williams SC,Dyson M,Dassi B,Walsh LP,Manna PR,Wang XJ,Zeleznik AJ,Orly J

    更新日期：2001-05-25 00:00:00

  • Flow cytometry analysis of cells dispersed from the MtTF4 tumor whose growth is inhibited by estradiol treatment.

    abstract：:The aim of this work was to determine whether treatments of rats with estradiol (E) in conditions known to decrease the proliferation rate, the mitotic index and the thymidine incorporation into the DNA of the MtTF4 tumor act at a specific point in the cell cycle. Two weeks after grafting a piece of tumor under the ki...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90046-8

    authors： Pharaboz MO,Cordier G,André J

    更新日期：1986-12-01 00:00:00

  • Calcium sites in MSH stimulation of xenopus melanophores: studies with photoreactive alpha-MSH.

    abstract：:Photo-affinity labelling of MSH receptors on tail-fin melanophores of Xenopus tadpoles with p-azidophenylalanine 13-alpha-MSH (Pap13)-alpha-MSH) or p-azidophenylacetyl-serine1-alpha-MSH ([Apac-Ser1]-alpha-MSH) resulted in a long-lasting stimulation of the melanophores which cannot be reversed despite continuous washin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90121-6

    authors： de Graan PN,Eberle AN,van de Veerdonk FC

    更新日期：1982-05-01 00:00:00

  • Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression.

    abstract：:Estrogen-related receptor alpha (ERRalpha) modulates estrogen receptor (ER)-mediated activity and is participating in the energy homeostasis by regulation of downstream target genes. The ERRalpha gene itself is proposed to be regulated by peroxisome proliferator-activated receptor gamma coactivator (PGC-1alpha) throug...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.11.002

    authors： Zhang Z,Teng CT

    更新日期：2007-01-29 00:00:00

  • FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.

    abstract：:The FOXO1 transcription factor is important for multiple aspects of reproductive function. We previously reported that FOXO1 functions as a repressor of gonadotropin hormone synthesis, but how FOXO1 is regulated in pituitary gonadotropes is unknown. The growth factors, insulin and insulin-like growth factor I (IGF1), ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.02.006

    authors： Skarra DV,Thackray VG

    更新日期：2015-04-15 00:00:00

  • Isolation of cells from rat seminal vesicles and epididymis and their use in studying androgen action.

    abstract：:Cells isolated enzymically from seminal vesicles and epididymides of normal and castrated rats were shown by electron microscopy to be intact and representative of the tissue. The cells synthesize and secrete tissue-specific proteins. Short-term incorporation of [3H]uridine and [35S]methionine was measured to determin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(81)90071-x

    authors： Higgins SJ,Brooks DE,Fuller FM

    更新日期：1981-08-01 00:00:00

  • KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort.

    abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.03.007

    authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

    更新日期：2016-05-15 00:00:00

  • Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes.

    abstract：BACKGROUND:Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.06.004

    authors： Bernardi S,Fabris B,Thomas M,Toffoli B,Tikellis C,Candido R,Catena C,Mulatero P,Barbone F,Radillo O,Zauli G,Secchiero P

    更新日期：2014-08-25 00:00:00

  • Expression of imprinted genes in human preimplantation development.

    abstract：:Imprinted gene expression in preimplantation development has been extensively studied in the mouse. Different imprinted genes vary in their time of onset of expression and also in the timing and tissue-specificity of mono-allelic expression. We have surveyed a range of imprinted genes for expression, and mono-allelic ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(01)00575-5

    authors： Monk M,Salpekar A

    更新日期：2001-10-22 00:00:00

  • Autoregulation of the rat prolactin gene in lactotrophs.

    abstract：:The autoregulation of prolactin (PRL) secretion in the rat has been demonstrated at both the hypothalamus and the pituitary levels. Studies on the direct negative feedback effect of PRL in the lactotrophs have concentrated on the acute effect on PRL secretion which does not involve change in PRL synthesis. In this stu...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00178-1

    authors： Devost D,Boutin JM

    更新日期：1999-12-20 00:00:00

  • Increased ornithine decarboxylase activity in kidneys undergoing hypertrophy in experimental diabetes.

    abstract：:Renal hypertrophy and hyperfiltration are early manifestations of human and experimental diabetes that may contribute to the late development of diabetic nephropathy. The biochemical events resulting in kidney growth in the diabetic state are completely unknown. Since growth of various tissues is accompanied by increa...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90176-7

    authors： Pedersen SB,Flyvbjerg A,Grønbaek H,Richelsen B

    更新日期：1992-07-01 00:00:00

  • Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2.

    abstract：:Testosterone can be converted into androstenedione (4-dione) by 17β-hydroxysteroid dehydrogenase (HSD) activity likely performed by 17β-HSD type 2. Our objective was to evaluate the rate of testosterone conversion to 4-dione as well as expression and localization of 17β-HSD type 2 in omental (OM) vs. subcutaneous (SC)...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.06.016

    authors： Fouad Mansour M,Pelletier M,Boulet MM,Mayrand D,Brochu G,Lebel S,Poirier D,Fradette J,Cianflone K,Luu-The V,Tchernof A

    更新日期：2015-10-15 00:00:00

  • TAK1 activation for cytokine synthesis and proliferation of endometriotic cells.

    abstract：:Endometriosis causes pelvic pain and infertility in women of reproductive age. We explored TNFalpha-induced specific signaling pathways and gene expressions in endometriotic stromal cells (ESCs). Based on the data of the pathway specific cDNA array, we analyzed the role of TAK1, which is believed to work as a common m...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2009.04.012

    authors： Taniguchi F,Harada T,Miyakoda H,Iwabe T,Deura I,Tagashira Y,Miyamoto A,Watanabe A,Suou K,Uegaki T,Terakawa N

    更新日期：2009-08-13 00:00:00

  • Isolation and characterisation of calcineurin from adrenal cell cytoskeleton: identification of substrates for Ca2+-calmodulin-dependent phosphatase activity.

    abstract：:Ca2+-calmodulin-dependent protein phosphatase activity is found in cytoskeletons of Y-1 mouse adrenal and bovine fasciculata cells. The activity is inhibited by three inhibitors of calmodulin (trifluoperazine, W-7 and pimozide) with EC50 in the low micromolar range. Protein phosphatase activity is inhibited by vanadat...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90078-6

    authors： Papadopoulos V,Brown AS,Hall PF

    更新日期：1989-05-01 00:00:00

  • Views on the co-evolution of the melanocortin-2 receptor, MRAPs, and the hypothalamus/pituitary/adrenal-interrenal axis.

    abstract：:A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R). Tetrapod and teleost MC2R orth...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2014.12.022

    authors： Dores RM,Garcia Y

    更新日期：2015-06-15 00:00:00

  • Dysregulated miR-137 and its target EGFR contribute to the progression of pituitary adenomas.

    abstract：:Pituitary adenomas (PAs) hypersecrete hormones or cause mass effect symptoms, with 10%-35% patients showing resistance to standard therapies. Targeting epidermal growth factor receptor (EGFR) has significantly improved the clinical outcome in many cancers. In this study, immunochemistry results showed that EGFR associ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2020.111083

    authors： Wei D,Yu Z,Cheng Y,Jiawei H,Jian G,Hua G,Guilan D

    更新日期：2021-01-15 00:00:00

  • Ovine 11 beta-hydroxysteroid dehydrogenase type 2 gene predicts a protein distinct from that deduced by the cloned kidney cDNA at the C-terminus.

    abstract：:The gene encoding ovine 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) was cloned and characterized. This gene consists of five exons and is greater than 4 kb in length. It contains an open reading frame of 1215 bp, which encodes a protein of 404 amino acids with a predicted MW of 44 kDa. The deduced ovine...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03775-6

    authors： Campbell LE,Yu M,Yang K

    更新日期：1996-05-17 00:00:00

  • Visualization of unoccupied and occupied gonadotropin-releasing hormone receptors in living cells.

    abstract：:Three chimeras of the rat GnRH receptor (rGnRHR) and an enhanced green fluorescent protein (GFP) were assessed to examine their suitability as probes of the receptor in transfected GH3 cells. Direct fusion of GFP to the N or C terminus of the rGnRHR abolished the receptor ligand binding affinity and the chimeric recep...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(98)00204-4

    authors： Lin X,Cornea A,Janovick JA,Conn PM

    更新日期：1998-11-25 00:00:00

  • The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells.

    abstract：:Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid retention; however, the effect of pioglitazone on aldost...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.07.007

    authors： Pan ZQ,Xie D,Choudhary V,Seremwe M,Tsai YY,Olala L,Chen X,Bollag WB

    更新日期：2014-08-25 00:00:00

  • Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein.

    abstract：:Desethylamiodarone (DEA), the major metabolite of the potent antiarrythmic drug amiodarone, is a non-competitive inhibitor of the binding of thyroid hormone (T3) to the beta 1-thyroid hormone receptor (T3R). In the present study, we investigated whether DEA acts in a similar way with respect to the alpha 1-T3R. The ch...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03578-u

    authors： van Beeren HC,Bakker O,Wiersinga WM

    更新日期：1995-07-01 00:00:00

  • Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition.

    abstract：:The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic diseases throughout the lifespan. In this study, a reduction in serum testosterone and an increase in estrogen levels were shown in older rats born to...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2020.111148

    authors： Portela LM,Santos SA,Constantino FB,Camargo AC,Colombelli KT,Fioretto MN,Barquilha CN,Périco LL,Hiruma-Lima CA,Scarano WR,Zambrano E,Justulin LA

    更新日期：2020-12-31 00:00:00

  • The role of FSCN1 in migration and invasion of pituitary adenomas.

    abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.10.021

    authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

    更新日期：2016-01-05 00:00:00

  • Effects of cyclic AMP elevation on the levels of insulin receptors in glial C6 cells.

    abstract：:The regulation of the insulin receptor by cAMP has been examined in glial C6 cells. Incubation for 48 h with dibutyryl cyclic AMP produced a dose-dependent inhibition of 125I-insulin binding to the cells. Other agents that elevate intracellular cAMP levels such as forskolin and cholera toxin mimicked the effect of thi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90127-5

    authors： Montiel F,Aranda A,Pascual A

    更新日期：1989-02-01 00:00:00

  • Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC).

    abstract：:In mammalian cells, the insulin receptor substrate 1 protein (IRS-1) is a specific substrate for insulin and IGF-1 receptor tyrosine kinases which is involved in mediating metabolic and mitogenic actions of insulin and IGFs. In order to determine if IRS-1 is also essential in a chicken derived hepatoma cell line (LMH ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(97)00245-1

    authors： Taouis M,Dupont J,Gillet A,Derouet M,Simon J

    更新日期：1998-02-01 00:00:00

  • Multigenic control of thyroid hormone functions in the nervous system.

    abstract：:Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated by alpha and beta isoforms of TH receptor which act as ligand-regulate...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.03.006

    authors： Nunez J,Celi FS,Ng L,Forrest D

    更新日期：2008-06-11 00:00:00

  • Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition.

    abstract：:The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the proces...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.01.022

    authors： Liu C,Zhu P,Wang W,Li W,Shu Q,Chen ZJ,Myatt L,Sun K

    更新日期：2016-03-15 00:00:00

  • Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus.

    abstract：:Our previous study revealed the particular expression patterns of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 1 (IGFBP1) in the Qinghai-Tibet plateau root vole (Microtus oeconomus) under hypoxic challenge. Here we report the molecular mechanisms of Igf gene regulation associated ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.05.025

    authors： Zhang S,Zhao Y,Hu X,Liu Z,Chen X,Chen X,Du J

    更新日期：2013-08-25 00:00:00

  • Nuclear Receptors in atherosclerosis: a superfamily with many 'Goodfellas'.

    abstract：:Nuclear Receptors form a superfamily of 48 transcription factors that exhibit a plethora of functions in steroid hormone signaling, regulation of metabolism, circadian rhythm and cellular differentiation. In this review, we describe our current knowledge on the role of Nuclear Receptors in atherosclerosis, which is a ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2012.05.014

    authors： Kurakula K,Hamers AA,de Waard V,de Vries CJ

    更新日期：2013-04-10 00:00:00

  • Expression of two isoforms of the human growth hormone receptor in normal liver and hepatocarcinoma.

    abstract：:In man, two isoforms of growth hormone receptor (GHR) have been reported. The first, hGHR corresponds to the original form described by Leung et al. (J. Biol. Chem. 264 (1987) 9905-9910). The second, hGHRd3, missing 22 N-terminal amino acids is encoded by an mRNA derived from alternative splicing and deletion of the t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(94)90064-7

    authors： Esposito N,Paterlini P,Kelly PA,Postel-Vinay MC,Finidori J

    更新日期：1994-07-01 00:00:00

  • Multiple sites of tumorigenesis in transgenic mice overproducing hCG.

    abstract：:We have produced transgenic (TG) mice expressing under the ubiquitin C promoter either the glycoprotein hormone common alpha-subunit (C(alpha)) or human chorionic gonadotropin (hCG) beta-subunit. C(alpha) overexpression alone had no phenotypic effect, but the hCG(beta) expressing females, presenting with moderately el...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2004.10.013

    authors： Huhtaniemi I,Rulli S,Ahtiainen P,Poutanen M

    更新日期：2005-04-29 00:00:00