Multigenic control of thyroid hormone functions in the nervous system.

Abstract:

:Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated by alpha and beta isoforms of TH receptor which act as ligand-regulated transcription factors. Receptor activity can be regulated at several levels including that of uptake of TH ligand and the activation or inactivation of ligand by deiodinase enzymes in target tissues. Processes under the control of TH range from learning and anxiety-like behaviour to sensory function. At the cellular level, TH controls events as diverse as axonal outgrowth, hippocampal synaptic activity and the patterning of opsin photopigments necessary for colour vision. Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity.

journal_name

Mol Cell Endocrinol

authors

Nunez J,Celi FS,Ng L,Forrest D

doi

10.1016/j.mce.2008.03.006

subject

Has Abstract

pub_date

2008-06-11 00:00:00

pages

1-12

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(08)00116-0

journal_volume

287

pub_type

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