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Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition.

Abstract：

:The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic diseases throughout the lifespan. In this study, a reduction in serum testosterone and an increase in estrogen levels were shown in older rats born to protein malnourished dams (6% protein in the diet) during gestation and lactation. Intraprostatic levels of reduced glutathione were decreased, while tissue expression of glutathione S-transferase pi and sulfiredoxin-1 were increased in these animals. Strong immunostaining for alfametilacil CoA racemase (AMACR), vascular endothelial growth factor-A (VEGF-A), and aquaporin-1 (AQP1) was also observed. In silico analysis confirmed commonly deregulated proteins in the ventral prostate of old rats and patients with prostate cancer. In conclusion, the increase in oxidative stress associated with an imbalance of sex hormones may contribute to prostate carcinogenesis in offspring, highlighting early-life malnutrition as a key risk factor for this malignance.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Portela LM,Santos SA,Constantino FB,Camargo AC,Colombelli KT,Fioretto MN,Barquilha CN,Périco LL,Hiruma-Lima CA,Scarano WR,Zambrano E,Justulin LA

doi

10.1016/j.mce.2020.111148

subject

Has Abstract

pub_date

2020-12-31 00:00:00

pages

111148

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(20)30450-0

journal_volume

523

pub_type

杂志文章

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