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Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes.

Abstract：

BACKGROUND:Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS development and progression. METHODOLOGY/PRINCIPAL FINDINGS:Circulating OPG was measured in 46 patients with MetS and 63 controls, and was found significantly elevated in those with MetS. In addition, circulating and tissue OPG was significantly increased in high-fat diet (HFD) fed C57BL6 mice, which is one of the animal models for the study of MetS. To evaluate the consequences of OPG elevation, we delivered this protein to C57BL6 mice, finding that it promoted systemic and adipose tissue proinflammatory changes in association with metabolic abnormalities. CONCLUSIONS/SIGNIFICANCE:These data suggest that OPG may trigger adipose tissue proinflammatory changes in MetS/HFD-induced obesity.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Bernardi S,Fabris B,Thomas M,Toffoli B,Tikellis C,Candido R,Catena C,Mulatero P,Barbone F,Radillo O,Zauli G,Secchiero P

doi

10.1016/j.mce.2014.06.004

subject

Has Abstract

pub_date

2014-08-25 00:00:00

pages

13-20

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00178-6

journal_volume

394

pub_type

杂志文章

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