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Puberty-related influences on brain development.

Abstract：

:Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Giedd JN,Clasen LS,Lenroot R,Greenstein D,Wallace GL,Ordaz S,Molloy EA,Blumenthal JD,Tossell JW,Stayer C,Samango-Sprouse CA,Shen D,Davatzikos C,Merke D,Chrousos GP

doi

10.1016/j.mce.2006.04.016

subject

Has Abstract

pub_date

2006-07-25 00:00:00

pages

154-62

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(06)00174-2

journal_volume

254-255

pub_type

杂志文章,评审

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