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Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.

Abstract：

:Environmental conditions in early life permanently alter the development of glucocorticoid receptor gene expression in the hippocampus and hypothalamic-pituitary-adrenal responses to acute or chronic stress. In part, these effects can involve an activation of ascending serotonergic pathways and subsequent changes in the expression of transcription factors that might drive glucocorticoid receptor expression in the hippocampus. This paper summarizes the evidence in favor of these pathways as well as recent studies describing regulatory targets on the promoter region of the rat hippocampal glucocorticoid receptor gene.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Weaver IC,La Plante P,Weaver S,Parent A,Sharma S,Diorio J,Chapman KE,Seckl JR,Szyf M,Meaney MJ

doi

10.1016/s0303-7207(01)00635-9

keywords:

subject

Has Abstract

pub_date

2001-12-20 00:00:00

pages

205-18

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303720701006359

journal_volume

185

pub_type

杂志文章,评审

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