Abstract：
:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes, with early-to-mid gestation T-exposed female rhesus monkeys exhibiting adult reproductive, endocrinological and metabolic dysfunctional traits that are co-pathologies of PCOS. Late gestational T exposure, while inducing adult ovarian hyperandrogenism and menstrual abnormalities, has less dysfunctional metabolic accompaniment. Fetal exposures to dihydrotestosterone (DHT) or diethylstilbestrol (DES) suggest androgenic and estrogenic aspects of fetal programming. Neonatal exposure to T produces no PCOS-like outcome, while continuous T treatment of juvenile females causes precocious weight gain and early menarche (high T), or high LH and weight gain (moderate T). Acute T exposure of adult females generates polyfollicular ovaries, while chronic T exposure induces subtle menstrual irregularities without metabolic dysfunction.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DAdoi
10.1016/j.mce.2013.01.013subject
Has Abstractpub_date
2013-07-05 00:00:00pages
21-8issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(13)00036-1journal_volume
373pub_type
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