Molecular features of thyroid oncocytic tumors.

abstract：:Valproic acid (VPA) has been shown to increase the reprogramming efficiency of induced pluripotent stem cells (iPSC) from somatic cells, but the mechanism by which VPA enhances iPSC induction has not been defined. Here we demonstrated that VPA directly activated Oct4 promoter activity through activation of the PI3K/Ak...

journal_title：Molecular and cellular endocrinology

authors： Teng HF,Li PN,Hou DR,Liu SW,Lin CT,Loo MR,Kao CH,Lin KH,Chen SL

更新日期：2014-03-05 00:00:00

abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

journal_title：Molecular and cellular endocrinology

authors： Kalfa N,Philibert P,Baskin LS,Sultan C

更新日期：2011-03-30 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have...

journal_title：Molecular and cellular endocrinology

authors： Stocco DM,Clark BJ,Reinhart AJ,Williams SC,Dyson M,Dassi B,Walsh LP,Manna PR,Wang XJ,Zeleznik AJ,Orly J

更新日期：2001-05-25 00:00:00

abstract：:The LHRH receptor in alpha T3-1 gonadotrope cells was shown to bring about a marked and sustained activation of MAP kinase. This response was prevented by protein kinase C inhibition or down-regulation and could be partially mimicked by phorbol ester. Additional evidence for inhibition of this response by pertussis to...

journal_title：Molecular and cellular endocrinology

authors： Sim PJ,Wolbers WB,Mitchell R

更新日期：1995-08-11 00:00:00

abstract：:The relationship between ATP-induced uptake of 45Ca2+ and the ATP-induced changes in [Ca2+]i was investigated in rat FRTL-5 thyroid cells. Addition of 1 microCi 45Ca2+/ml together with ATP induced a time- and dose-dependent increase in uptake of 45Ca2+, the uptake being still significantly above control after 30 min. ...

journal_title：Molecular and cellular endocrinology

authors： Törnquist K

更新日期：1991-08-01 00:00:00

abstract：:PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. ...

journal_title：Molecular and cellular endocrinology

authors： Athanason MG,Ratliff WA,Chaput D,MarElia CB,Kuehl MN,Stevens SM Jr,Burkhardt BR

更新日期：2016-11-15 00:00:00

abstract：:Testicular peritubular cells produce paracrine mediators which modulate Sertoli cell function. The production of these mediators (P Mod-S) is controlled by androgens suggesting that mesenchymal-epithelial interactions play an important role in androgen action in the testis. We investigated whether mesenchymal cells fr...

journal_title：Molecular and cellular endocrinology

authors： Swinnen K,Cailleau J,Heyns W,Verhoeven G

更新日期：1989-03-01 00:00:00

abstract：:Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcuta...

journal_title：Molecular and cellular endocrinology

authors： Rodriguez-Sosa JR,Bondareva A,Tang L,Avelar GF,Coyle KM,Modelski M,Alpaugh W,Conley A,Wynne-Edwards K,França LR,Meyers S,Dobrinski I

更新日期：2014-12-01 00:00:00

abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

journal_title：Molecular and cellular endocrinology

authors： Thompson BR,Lobo S,Bernlohr DA

更新日期：2010-04-29 00:00:00

abstract：:Polymerase chain reaction (PCR) amplification of nt 4502 to nt 5184 of the thyroglobulin (Tg) mRNA from several patients, with or without elevated serum thyrotropin (TSH), showed a predominant fragment of the expected size (683 bp) and a minor fragment of 512 bp. The sequence of this minor fragment revealed that 171 b...

journal_title：Molecular and cellular endocrinology

authors： Targovnik HM,Cochaux P,Corach D,Vassart G

更新日期：1992-03-01 00:00:00

abstract：:Cell-based studies previously showed that the ATP-binding cassette transporter A1 (ABCA1) transfers cholesterol across mammary epithelial cells (MEC). Data for phospholipid transport are lacking, and it is unclear from which cellular source the transported cholesterol stems, whether this transport activates signaling ...

journal_title：Molecular and cellular endocrinology

authors： Ontsouka CE,Huang X,Aliyev E,Albrecht C

更新日期：2017-01-05 00:00:00

abstract：:In two sublines of the estrogen receptor-positive human breast cancer cell line, MCF-7, propagated with 0.5% fetal calf serum (FCS) (subline 0.5) and without serum (subline 9), respectively, addition of 10% newborn calf serum (NCS) inhibits cell proliferation and stimulates the secretion of a 42 kDa protein. Both with...

journal_title：Molecular and cellular endocrinology

authors： Lykkesfeldt AE,Laursen I,Briand P

更新日期：1989-04-01 00:00:00

abstract：:Procedures have been developed which provide simple means of determining binding constants of steroid receptors for glucocorticoids in mouse lymphoid cell lines and of characterizing the interaction of the steroid--receptor complex with the nucleus. An average of 70% of the steroid--receptor complexes is found associa...

journal_title：Molecular and cellular endocrinology

authors： Pfahl M,Sandros T,Bourgeois S

更新日期：1978-04-01 00:00:00

abstract：:Spermatogonial transplantation as developed in the laboratory of Ralph Brinster has been a technological breakthrough in the study of Sertoli-germ cell interactions. For the first time, germ cells can be transferred from one animal to another and from one species to another. The transfer technology combined with devel...

journal_title：Molecular and cellular endocrinology

authors： Russell LD,Griswold MD

更新日期：2000-03-30 00:00:00

abstract：:Emerging evidence shows a beneficial effect of estrogens for Parkinson's disease, yet the exact potency of these compounds implicated remain obscured. In this study, we investigated the neuroprotective effect of 17beta-estradiol and estrone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal t...

journal_title：Molecular and cellular endocrinology

authors： Ookubo M,Yokoyama H,Takagi S,Kato H,Araki T

更新日期：2008-12-16 00:00:00

abstract：:Studies were conducted in vitro and in vivo to determine whether or not inhibin affects the transcription rate of the gene for the beta subunit of follicle stimulating hormone (FSH beta). Pituitary cells in primary culture were incubated with 0-3000 milli-units/ml inhibin; a dose-related decrement in mRNA was obtained...

journal_title：Molecular and cellular endocrinology

authors： Clarke IJ,Rao A,Fallest PC,Shupnik MA

更新日期：1993-02-01 00:00:00

abstract：:Protection of the spermatogenic cells from the host immune response is fundamental to male fertility. Significantly, this protection extends to the tolerance of foreign tissue grafts placed within the testicular environment, a phenomenon that is called 'immune privilege'. This privilege of the testis appears to involv...

journal_title：Molecular and cellular endocrinology

authors： Meinhardt A,Hedger MP

更新日期：2011-03-15 00:00:00

abstract：:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in...

journal_title：Molecular and cellular endocrinology

authors： Wang CY,Chen WY,Lai PY,Chung BC

更新日期：2013-05-22 00:00:00

abstract：:We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps deliv...

journal_title：Molecular and cellular endocrinology

authors： Haberkorn V,Heydel JM,Mounie J,Artur Y,Goudonnet H

更新日期：2002-04-25 00:00:00

abstract：:It has already been shown that Wistar rat thyroid (WRT) cells in low concentrations of calf serum (0.5%) are under the influence of both thyrotropin (TSH) and insulin as regards growth. The present data show that epidermal growth factor (EGF), in concentrations up to 10 micrograms/ml, is not able to modify DNA synthes...

journal_title：Molecular and cellular endocrinology

authors： Rotella CM,Mavilia C,Frediani U,Toccafondi R

更新日期：1989-08-01 00:00:00

abstract：:Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation emb...

journal_title：Molecular and cellular endocrinology

authors： You JL,Wang W,Tang MY,Ye YH,Liu AX,Zhu YM

更新日期：2018-07-15 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

journal_title：Molecular and cellular endocrinology

authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

更新日期：2013-01-05 00:00:00

abstract：:Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western co...

journal_title：Molecular and cellular endocrinology

authors： Asrih M,Jornayvaz FR

更新日期：2015-12-15 00:00:00

abstract：:Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and, indeed, it has been demonstrated that SRIF and its analogs can inhibit pituitary tumor hormone secretion and control neoplastic bulk. Several in vitro studies have contributed to the current knowledge of the mechanisms by which SR...

journal_title：Molecular and cellular endocrinology

authors： Zatelli MC,Ambrosio MR,Bondanelli M,degli Uberti EC

更新日期：2008-05-14 00:00:00

abstract：:A small litter (SL) model was used to determine how neonatal overfeeding affects the homeostatic control of food intake in male rats at weaning and postnatal day (PND) 90. At PND4, litters were reduced to small (4 pups/dam) or normal (10 pups/dam) litters. At weaning, SL rats showed higher body weight and characterist...

journal_title：Molecular and cellular endocrinology

authors： Schumacher R,Rossetti MF,Lazzarino GP,Canesini G,García AP,Stoker C,Andreoli MF,Ramos JG

更新日期：2021-02-15 00:00:00

abstract：:The ability of angiotensin-II (A-II) to increase cAMP production in adrenocortical cells is not widely accepted due to numerous conflicting reports. The recent observation that rat adrenal cells exhibit multiple subtypes of A-II receptors raises the possibility that a specific subtype could be responsible for controll...

journal_title：Molecular and cellular endocrinology

authors： Rainey WE,Byrd EW,Sinnokrot RA,Carr BR

更新日期：1991-10-01 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:The effects of calcitonin (CT) on the cellular transport and accumulation of Ca were studied in bone cells grown in primary culture. The following sequence of events was detected: (1) After 1--2 h of incubation with CT the initial rate of Ca influx into bone cells transiently increased. A longer incubation with CT (3-...

journal_title：Molecular and cellular endocrinology

authors： Eilam Y,Szydel N,Harell A

更新日期：1980-06-01 00:00:00

abstract：:An enzyme system capable of monodeiodinating T4 to T3 and to rT3 in a microsomal fraction of normal human thyroid tissue is characterized. The pH optimum for 5'-monodeiodination of T4 to T3 was around 7.0 The Km (apparent) for the conversion of T4 to T3 was 5.7 mumoles/l. PTU, ipodate and rT3 inhibited T4 deiodination...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P

更新日期：1984-10-01 00:00:00