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Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome.

Abstract：

:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Wang CY,Chen WY,Lai PY,Chung BC

doi

10.1016/j.mce.2012.11.019

subject

Has Abstract

pub_date

2013-05-22 00:00:00

pages

148-53

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(12)00511-4

journal_volume

371

pub_type

杂志文章,评审

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