Regulation of progesterone and prostaglandin F2alpha production in the CL.

Abstract:

:After the luteinizing hormone (LH) surge, the cells that remain from the ovulated follicle undergo a process of differentiation termed luteinization. Two key features of the cells after luteinization are the capacity for tremendous production of progesterone [10(16) molecules of progesterone per (min/(g of CL))] and the capacity to undergo regression or death of the cells at the appropriate time. There are two steroidogenic cell types, the small and large luteal cells that are regulated by different mechanisms. In small luteal cells, production of progesterone is stimulated by LH through the protein kinase A (PKA) pathway. The large luteal cells of ruminants produce large quantities of progesterone that is independent of LH stimulation. Although luteotrophins clearly regulate luteal function, much of luteal progesterone production in some species appears to be constitutive, consistent with the autonomous aspects of the large luteal cell. The key regulated step in luteal progesterone production appears to be regulation of transport of cholesterol to the inner mitochondrial membrane apparently mediated by the steroidogenic acute regulatory protein (StAR). In addition, our recent research indicates that PKA is tonically active in large luteal cells and this may be responsible for the high, relatively autonomous nature of luteal progesterone production. Regression of the corpus luteum (CL) in many species is initiated by prostaglandin (PG) F2alpha secreted from the uterus. Luteal cells also have the capacity for production of PGF2alpha. Luteal PGF2alpha production can be regulated by a variety of substances including inhibition by progesterone and stimulation by cytokines. We have also characterized a positive feedback pathway in ruminant and porcine CL in which small amounts of uterine PGF(2alpha) stimulate intraluteal production of PGF2alpha due to induction of the cycloxygenase-2 (Cox-2) enzyme in large luteal cells. This positive feedback pathway is only present in CL that has acquired the capacity for luteal regression ( approximately day 7 in cow, approximately day 13 in pig). Regulation by protein kinase C (PKC) of transcriptional factors interacting with an E-box in the 5' flanking region of the Cox-2 gene is the critical regulatory element involved in this positive feedback pathway. Thus, luteinization in some species appears to change specific gene transcription such that progesterone production becomes relatively independent of acute luteotrophic regulation and intraluteal PGF2alpha synthesis is induced by the second messenger pathways that are activated by PGF2alpha.

journal_name

Mol Cell Endocrinol

authors

Diaz FJ,Anderson LE,Wu YL,Rabot A,Tsai SJ,Wiltbank MC

doi

10.1016/s0303-7207(02)00056-4

keywords:

subject

Has Abstract

pub_date

2002-05-31 00:00:00

pages

65-80

issue

1

eissn

0303-7207

issn

1872-8057

pii

S0303720702000564

journal_volume

191

pub_type

杂志文章,评审
  • Role of estrone on the regulation of osteoblastogenesis.

    abstract::Although estradiol bone contribution has been deeply studied, little is known about the action of estrone. We investigated the direct action of estrone on osteoblasts growth and differentiation, with focus on the biochemical mechanism displayed by the estrogen. Murine calvarial osteoblast cultures in vitro exposed to ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2019.110582

    authors: Crescitelli MC,Rauschemberger MB,Cepeda S,Sandoval M,Massheimer VL

    更新日期:2019-12-01 00:00:00

  • ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines.

    abstract::Corticotropin (ACTH) binds to specific receptors in the adrenal cortex and thereby regulates glucocorticoid and mineralocorticoid production. The number of ACTH binding sites on adrenocortical cells is increased by exposure of cells to activators of the cAMP pathway. The mechanism responsible for the increase in ACTH ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/0303-7207(94)90160-0

    authors: Mountjoy KG,Bird IM,Rainey WE,Cone RD

    更新日期:1994-02-01 00:00:00

  • Molecular action of androgens.

    abstract::The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: ex...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/s0303-7207(02)00364-7

    authors: Gobinet J,Poujol N,Sultan Ch

    更新日期:2002-12-30 00:00:00

  • Expression and regulation of transient receptor potential cation channel, subfamily M, member 2 (TRPM2) in human endometrium.

    abstract::To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2012.10.015

    authors: Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

    更新日期:2013-01-30 00:00:00

  • Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation.

    abstract::Since all-trans retinoic acid (ATRA) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of ATRA on thyroid carcinoma and to evaluate the effectiveness of ATRA in redifferentiation induction of thyroid carcinoma. Therefore, we investigated cell growth rate,...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2011.09.002

    authors: Malehmir M,Haghpanah V,Larijani B,Ahmadian S,Alimoghaddam K,Heshmat R,Ghavamzadeh A,Adabi K,Ghaffari SH

    更新日期:2012-01-02 00:00:00

  • Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors.

    abstract::Recently, we have identified three distinct types of gonadotropin-releasing hormone receptor (GnRHR) in the bullfrog (designated bfGnRHR-1, bfGnRHR-2, and bfGnRHR-3). In the present study, we compared G protein coupling preference of mammalian and nonmammalian GnRHRs. In a transient expression system, stimulation of e...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/s0303-7207(03)00204-1

    authors: Oh DY,Wang L,Ahn RS,Park JY,Seong JY,Kwon HB

    更新日期:2003-07-31 00:00:00

  • A diabetes insipidus vasopressin prohormone altered outside the central core of neurophysin accumulates in the endoplasmic reticulum.

    abstract::Over 20 mutations affecting the neurophysin moiety of the vasopressin prohormone, have been identified in families suffering from familial neurohypophysial diabetes insipidus (FNDI). Only one of these, NP87E-->stop, is located outside the central conserved domain implicated in sorting of the vasopressin prohormone. To...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/s0303-7207(00)00288-4

    authors: Nijenhuis M,Zalm R,Burbach JP

    更新日期:2000-09-25 00:00:00

  • Tissue-specific corticosteroidogenesis in the rat.

    abstract::The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/s0303-7207(00)00258-6

    authors: Rudolph AE,Blasi ER,Delyani JA

    更新日期:2000-07-25 00:00:00

  • GnRH-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion.

    abstract::In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1-5). GnRH-(1-5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1-5) acts on the orphan G protein-coupled...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2015.08.010

    authors: Cho-Clark M,Larco DO,Zahn BR,Mani SK,Wu TJ

    更新日期:2015-11-05 00:00:00

  • Cytochrome b5: novel roles in steroidogenesis.

    abstract::Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2012.11.020

    authors: Storbeck KH,Swart AC,Goosen P,Swart P

    更新日期:2013-05-22 00:00:00

  • Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling.

    abstract::Vitamin D is a key factor for calcium and bone homeostasis, but signalling through the vitamin D receptor (VDR) seems also to be important for testicular function. To test the functional role of vitamin D signalling we examined the male reproductive system of the Leuven Vdr-ablated (Vdr(-/-)) mice, previously establis...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2013.06.036

    authors: Blomberg Jensen M,Lieben L,Nielsen JE,Willems A,Jørgensen A,Juul A,Toppari J,Carmeliet G,Rajpert-De Meyts E

    更新日期:2013-09-05 00:00:00

  • Actions of 5alpha-reductase inhibitors on the epididymis.

    abstract::Testosterone is converted to the more biologically active androgen, dihydrotestosterone (DHT), by steroid 5alpha-reductase. Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spe...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2005.12.044

    authors: Robaire B,Henderson NA

    更新日期:2006-05-16 00:00:00

  • Down-regulation of vascular endothelial growth factor in renal cell carcinoma cells by glucocorticoids.

    abstract::Metastatic renal cell carcinomas (RCC) remain highly resistant to systemic therapy. RCCs are highly vascular tumors, which overproduce angiogenic peptides such as vascular endothelial growth factor (VEGF) even under normoxic conditions. A potential suggested role of antiangiogenic therapeutic strategies is the treatme...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2004.07.013

    authors: Iwai A,Fujii Y,Kawakami S,Takazawa R,Kageyama Y,Yoshida MA,Kihara K

    更新日期:2004-10-29 00:00:00

  • PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells.

    abstract::Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and growth in others. We examined whether PTHrP production is greater in well-differentiated or growing beta cells and whether PTHrP induces differentiation or growth in...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/s0303-7207(01)00482-8

    authors: Sawada Y,Zhang B,Okajima F,Izumi T,Takeuchi T

    更新日期:2001-09-01 00:00:00

  • PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.

    abstract::Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, PC2, CPE and preproNPY protein expression levels were compared among m...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2009.01.020

    authors: Tang SS,Zhang JH,Liu HX,Li HZ

    更新日期:2009-05-06 00:00:00

  • Melanocortin receptors and their accessory proteins.

    abstract::The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for thei...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2010.07.015

    authors: Cooray SN,Clark AJ

    更新日期:2011-01-15 00:00:00

  • Characterization of nuclear triiodothyronine (T3) and tetraiodothyronine (T4) binding in developing brain tissue.

    abstract::The main objective of this study was to characterize nuclear T3 and T4 binding in the developing rat brain. More specifically, we sought to determine (a) whether T3 and T4 bind to the same nuclear receptor, (b) whether there are multiple forms of nuclear T3 or T4 receptors, and (c) whether the above parameters are sim...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/0303-7207(83)90158-2

    authors: Margarity M,Matsokis N,Valcana T

    更新日期:1983-08-01 00:00:00

  • AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

    abstract::Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by progesterone or synthetic progestins. Estrogen and progestin action is regulated at the pre-receptor level, by interconversion of active hormones (estradiol (E2), prog...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2005.10.009

    authors: Rizner TL,Smuc T,Rupreht R,Sinkovec J,Penning TM

    更新日期:2006-03-27 00:00:00

  • Estrogen receptor mutations.

    abstract::The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms....

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/s0303-7207(98)00170-1

    authors: Taylor JA,Lewis KJ,Lubahn DB

    更新日期:1998-10-25 00:00:00

  • Molecular and functional studies of 4 candidate loci in Pendred syndrome and nonsyndromic hearing loss.

    abstract::Patients with PS or non-syndromic deafness were submitted to genetic/functional analyzes of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator FOXI1, and of the potassium channel KCNJ10. SLC26A4 was the most frequently mutated gene. An altered intracellular localization with immunocyt...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2012.01.013

    authors: Cirello V,Bazzini C,Vezzoli V,Muzza M,Rodighiero S,Castorina P,Maffini A,Bottà G,Persani L,Beck-Peccoz P,Meyer G,Fugazzola L

    更新日期:2012-04-04 00:00:00

  • Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.

    abstract::The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2003.08.009

    authors: Qi H,Grenier J,Fournier A,Labrie C

    更新日期:2003-11-28 00:00:00

  • Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.

    abstract::The classic renin-angiotensin system (RAS) is a complex system in which angiotensin II (Ang II) has been identified as an important endogenous regulator that influences both smooth muscle contraction and cell growth. Although a local RAS is known to exist in the gastrointestinal tract, it is unclear whether Ang II is ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2016.01.002

    authors: Zhang CM,Huang X,Lu HL,Meng XM,Liu DH,Kim YC,Xu WX

    更新日期:2016-03-05 00:00:00

  • cAMP signalling in the normal and tumorigenic pituitary gland.

    abstract::cAMP signalling plays a key role in the normal physiology of the pituitary gland, regulating cellular growth and proliferation, hormone production and release. Deregulation of the cAMP signalling pathway has been reported to be a common occurrence in pituitary tumorigenesis. Several mechanisms have been implicated inc...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2014.05.004

    authors: Formosa R,Vassallo J

    更新日期:2014-07-05 00:00:00

  • Specific DNA binding and transactivation potential of recombinant, purified Stat5.

    abstract::The signal transducers and activators of transcriptions (Stats) are central mediators of cytokine responses especially in hematopoietic cells. The detailed molecular mechanisms of Stat activation, particularly the role of post-translational modifications and co-operation with cellular transcription factors are subject...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/s0303-7207(01)00588-3

    authors: Beisenherz-Huss C,Mundt M,Herrala A,Vihko P,Schubert A,Groner B

    更新日期:2001-10-25 00:00:00

  • Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

    abstract::Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2016.06.014

    authors: Villa-Osaba A,Gahete MD,Cordoba-Chacon J,de Lecea L,Castaño JP,Luque RM

    更新日期:2016-10-15 00:00:00

  • Homologous ligand induction of pituitary gonadotrophin-releasing hormone receptors in vivo is protein synthesis dependent.

    abstract::This study demonstrates that a single subcutaneous injection of gonadotrophin-releasing hormone (GnRH) (60 ng) to GnRH-deficient (hpg) male mice causes a doubling of pituitary GnRH receptors (GnRH-R). No change in GnRH-R occurs during the time of LH release (15-60 min) or up until 4 h post-GnRH. Between 4 and 12 h the...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/0303-7207(84)90045-5

    authors: Detta A,Naik SI,Charlton HM,Young LS,Clayton RN

    更新日期:1984-09-01 00:00:00

  • 11Beta-hydroxysteroid dehydrogenases in human endometrium.

    abstract::Key reproductive events, such as menstruation and implantation, are considered to be inflammatory processes and glucocorticoids act as anti-inflammatory agents. The balance of expression of types 1 and 2 11beta-hydroxysteroid dehydrogenases (11betaHSD) controls the availability of cortisol to bind to the glucocorticoi...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2005.12.010

    authors: McDonald SE,Henderson TA,Gomez-Sanchez CE,Critchley HO,Mason JI

    更新日期:2006-03-27 00:00:00

  • Physiology and pathology of somatostatin in the mammalian retina: a current view.

    abstract::In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst(1)-sst(5)) and the variety of si...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2007.12.009

    authors: Cervia D,Casini G,Bagnoli P

    更新日期:2008-05-14 00:00:00

  • Progesterone and subsequent polar metabolites are essential for completion of the first meiotic division in amphibian oocytes.

    abstract::We find that completion of the first meiotic division in Rana pipiens oocytes requires the sequential action of at least two steroids: progesterone and one or more subsequent polar metabolites of progesterone. Progesterone binding in vitro to oocyte surface receptors increases during the first 4-5h of exposure, follow...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章

    doi:10.1016/j.mce.2008.05.013

    authors: Kostellow AB,Morrill GA

    更新日期:2008-09-10 00:00:00

  • New methods for investigating experimental human adrenal tumorigenesis.

    abstract::Adenomas and nodules of the human adrenal cortex are common, whereas adrenocortical carcinomas are rare. Genes such as IGF2 have been suggested to be important in human adrenocortical tumorigenesis but their role has not been directly investigated. We describe here elements of a system in which hypotheses concerning t...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mce.2008.10.046

    authors: Cardoso CC,Bornstein SR,Hornsby PJ

    更新日期:2009-03-05 00:00:00