Pregnenolone synthesis in immature rat Sertoli cells.

abstract：BACKGROUND/PURPOSE:It remains unclear what role curcumin plays in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis, since some researchers found that curcumin has the ability to inhibit osteoclastogenesis. While others have considered it as an autophagy activator. This study aimed to determine th...

journal_title：Molecular and cellular endocrinology

authors： Ke D,Wang Y,Yu Y,Wang Y,Zheng W,Fu X,Han J,Zhang G,Xu J

更新日期：2020-01-15 00:00:00

abstract：:Menin is a protein product of a tumor suppressor gene MEN1, mutations of which are responsible for multiple endocrine neoplasia type 1, an autosomal dominant familial cancer syndrome. We isolated rat menin cDNA clones from a fetal rat brain cDNA library. We also determined the nucleotide sequence of the protein coding...

journal_title：Molecular and cellular endocrinology

authors： Maruyama K,Tsukada T,Hosono T,Ohkura N,Kishi M,Honda M,Nara-Ashizawa N,Nagasaki K,Yamaguchi K

更新日期：1999-10-25 00:00:00

abstract：:17Beta hydroxysteroid dehydrogenase type 7 (HSD17B7) was described to possess dual functionality in steroidogenesis as well as in postsqualene cholesterol biosynthesis in vitro. In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the...

journal_title：Molecular and cellular endocrinology

authors： Ohnesorg T,Adamski J

更新日期：2006-03-27 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

journal_title：Molecular and cellular endocrinology

authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

更新日期：2003-04-28 00:00:00

abstract：:South African Angora goats are susceptible to cold stress, due to their inability to produce sufficient levels of cortisol. During adrenal steroidogenesis the production of cortisol relies on the activity of two key enzymes, namely cytochrome P450 17alpha-hydroxylase and 3beta-hydroxysteroid dehydrogenase. Cytochrome ...

journal_title：Molecular and cellular endocrinology

authors： Goosen P,Swart AC,Storbeck KH,Swart P

更新日期：2010-02-05 00:00:00

abstract：:Administration of hydrocortisone to adrenalectomised rats elevated levels of both free and membrane-bound polysomes in liver and led to marked shifts in their sedimentation profiles in favour of heavier polysomes. The rate of nascent polypeptide formation was also found to be enhanced in response to the hormone but th...

journal_title：Molecular and cellular endocrinology

authors： Kulkarni SB,Netrawali MS,Pradhan DS,Sreenivasan A

更新日期：1976-02-01 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:The number of adipocyte progenitors is determined early in foetal and neonatal development in a process which may be altered by gender and excess nutrient intake, and which in turn determines fat mass in adulthood and the risk of developing obesity. Here we investigate the hypothesis that excess nutrients, in this cas...

journal_title：Molecular and cellular endocrinology

authors： Petrighi Polidori G,Lomax MA,Docherty K

更新日期：2012-09-25 00:00:00

abstract：:Stanniocalcin-1 (STC-1) is made by kidney collecting duct cells for autocrine and paracrine targeting of nephron cell mitochondria. Here, the ligand stimulates respiratory uncoupling and calcium uniport activity. However, the underlying purpose of these actions and how the renal gene is regulated are poorly understood...

journal_title：Molecular and cellular endocrinology

authors： Turner J,Xiang FL,Feng Q,Wagner GF

更新日期：2011-01-01 00:00:00

abstract：:Resistance to thyroid hormone can be due to heterozygous, dominant negative (DN) THRA (RTHα) or THRB (RTHβ) mutations, but the underlying mechanisms are incompletely understood. Here, we delineate the spatiotemporal expression of TH receptors (TRs) in zebrafish and generated morphants expressing equivalent amounts of ...

journal_title：Molecular and cellular endocrinology

authors： Marelli F,Carra S,Agostini M,Cotelli F,Peeters R,Chatterjee K,Persani L

更新日期：2016-03-15 00:00:00

abstract：:The mechanism by which growth hormone-binding protein (GH-BP) is generated in humans remains unclear. To address this question, we analysed human GH-receptor/GH-BP gene expression in a human hepatoma cell line (HuH7). Northern hybridisation showed that HuH7 cells contain a single mRNA species hybridising with a probe ...

journal_title：Molecular and cellular endocrinology

authors： Mullis PE,Holl RW,Lund T,Eblé A,Brickell PM

更新日期：1995-06-01 00:00:00

abstract：:In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α-provoked changes in the corpus luteum a short time-course (0.5-4 h) was performed on cows at midcycle. A microarray-determined transcriptome was...

journal_title：Molecular and cellular endocrinology

authors： Talbott H,Hou X,Qiu F,Zhang P,Guda C,Yu F,Cushman RA,Wood JR,Wang C,Cupp AS,Davis JS

更新日期：2017-09-05 00:00:00

abstract：:Porcine Leydig cells in primary culture were incubated to equilibrium with increasing doses of either porcine luteinizing hormone (pLH) or human chorionic gonadotropin (hCG). Then, free and total high affinity gonadotropin receptors on the cell surface were dosed with [125I]hCG as tracer. In isotonic high salt medium,...

journal_title：Molecular and cellular endocrinology

authors： Genty N,Salesse R,Jallal B,Garnier J

更新日期：1991-04-01 00:00:00

abstract：:Diabetes-induced neutrophil NETosis impairs wound healing through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-triggered activation of mitogen-activated protein kinase (MAPK) ERK1/2 and p38 is involved in NETosis. Hydrogen sulfide (H2S), an endogenous signaling molecule, accelerates diabetic wo...

journal_title：Molecular and cellular endocrinology

authors： Yang CT,Chen L,Chen WL,Li N,Chen MJ,Li X,Zheng X,Zhao YZ,Wu YX,Xian M,Liu J

更新日期：2019-01-15 00:00:00

abstract：OBJECTIVES:The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos. METHODS:The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched bl...

journal_title：Molecular and cellular endocrinology

authors： Sato N,Kawamura K,Fukuda J,Honda Y,Sato T,Tanikawa H,Kodama H,Tanaka T

更新日期：2003-04-28 00:00:00

abstract：:Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting...

journal_title：Molecular and cellular endocrinology

authors： Villa-Osaba A,Gahete MD,Cordoba-Chacon J,de Lecea L,Castaño JP,Luque RM

更新日期：2016-10-15 00:00:00

abstract：:Cell-based studies previously showed that the ATP-binding cassette transporter A1 (ABCA1) transfers cholesterol across mammary epithelial cells (MEC). Data for phospholipid transport are lacking, and it is unclear from which cellular source the transported cholesterol stems, whether this transport activates signaling ...

journal_title：Molecular and cellular endocrinology

authors： Ontsouka CE,Huang X,Aliyev E,Albrecht C

更新日期：2017-01-05 00:00:00

abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

journal_title：Molecular and cellular endocrinology

authors： Kalfa N,Philibert P,Baskin LS,Sultan C

更新日期：2011-03-30 00:00:00

abstract：:Studies on the age-related decline of growth hormone (GH) release have ignored that the population of GH-producing cells (somatotropes) is heterogeneous. In aging male rats, centrifugation of dispersed pituitary cells in a density gradient yields two somatotrope subpopulations, i.e. low- (LD) and high-density (HD) cel...

journal_title：Molecular and cellular endocrinology

authors： Dobado-Berrios PM,Ruiz-Navarro A,Lopez-Pedrera R,Gonzalez de Aguilar JL,Torronteras R,Hidalgo-Diaz C,Gracia-Navarro F

更新日期：1996-10-30 00:00:00

abstract：:Here we report the identification and characterization of ghrelin (GRLN) receptors in goldfish Carassius auratus. We identified four distinct mRNAs generated from four different genes. Those were roughly divided into two types, based on the number of amino acids and amino acid sequence similarity; one composed of 360-...

journal_title：Molecular and cellular endocrinology

authors： Kaiya H,Miura T,Matsuda K,Miyazato M,Kangawa K

更新日期：2010-10-07 00:00:00

abstract：:G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective ro...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Zhang Q,Yang L,Dong Y,Khan M,Yang F,Brann DW,Wang R

更新日期：2014-04-25 00:00:00

abstract：:Our previous study revealed the particular expression patterns of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 1 (IGFBP1) in the Qinghai-Tibet plateau root vole (Microtus oeconomus) under hypoxic challenge. Here we report the molecular mechanisms of Igf gene regulation associated ...

journal_title：Molecular and cellular endocrinology

authors： Zhang S,Zhao Y,Hu X,Liu Z,Chen X,Chen X,Du J

更新日期：2013-08-25 00:00:00

abstract：:The expression of prostatic acid phosphatase (PAcP) in three human prostate carcinoma cell lines including LNCaP, DU 145 and PC-3, was studied to explore its potential role as a marker in the progression of prostate cancer. Although Southern blot analysis suggested the presence of PAcP gene in all three prostate carci...

journal_title：Molecular and cellular endocrinology

authors： Garcia-Arenas R,Lin FF,Lin D,Jin LP,Shih CC,Chang C,Lin MF

更新日期：1995-04-28 00:00:00

abstract：:The ovarian granulosa cell has previously been shown to be a site of insulin-like growth factor (IGF) I production, reception, and action. It is the objective of this study to characterize in greater detail the soluble IGF binding activity released by this cell type. To this end, use was made of granulosa cells from i...

journal_title：Molecular and cellular endocrinology

authors： Adashi EY,Resnick CE,Hernandez ER,Hurwitz A,Rosenfeld RG

更新日期：1990-12-21 00:00:00

abstract：:The most widely conserved mammalian sperm antigen is sperm adhesion molecule 1, SPAM1/PH-20, which is also the major testicular hyaluronidase. This multifunctional glycosyl phosphatidylinositol (GPI)-linked protein plays several roles in fertilization and is encoded by a gene that resides among hyaluronidase family me...

journal_title：Molecular and cellular endocrinology

authors： Martin-DeLeon PA

更新日期：2006-05-16 00:00:00

abstract：:Adrenal binding protein 4 (Ad4BP) known also as steroidogenic factor 1 (SF-1) is a cell specific transcription factor regulating all steroidogenic P450 genes and is present exclusively in steroidogenic tissues. In this study, we examined whether Ad4BP expression is affected by oncogene-induced cell transformation. Usi...

journal_title：Molecular and cellular endocrinology

authors： Keren-Tal I,Dantes A,Plehn-Dujowich D,Amsterdam A

更新日期：1997-03-14 00:00:00

abstract：:Thyroid hormones suppress transcription of the gene for the beta-subunit of thyrotropin (TSH beta). Since the TSH beta gene in both the mouse and the rat contains two start sites of transcription in exon 1, we have investigated whether expression of the gene from each start site is differentially regulated by thyroid ...

journal_title：Molecular and cellular endocrinology

authors： Gurr JA,Januszeski MM,Tidikis IM,Norcross JJ,Kourides IA

更新日期：1990-07-09 00:00:00

abstract：:Brown adipose tissue (BAT) has been also considered as the main thermogenic organ responsible of maintenance body temperature through heat production. However, a new type of thermogenic fat has been characterized during the last years, the beige or brite fat, that is developed from white adipose tissue (WAT) in respon...

journal_title：Molecular and cellular endocrinology

authors： Contreras C,Nogueiras R,Diéguez C,Medina-Gómez G,López M

更新日期：2016-12-15 00:00:00