Curcumin-activated autophagy plays a negative role in its anti-osteoclastogenic effect.

abstract：:The ovulatory process is characterized by tissue wounding and, after oocyte expulsion, by healing being connected to the formation of a corpus luteum (CL). The ovulatory event thus compares with a sterile inflammation. The concept is forwarded that the ovulatory process depends on innate immunity (INIM) function. The ...

journal_title：Molecular and cellular endocrinology

authors： Spanel-Borowski K

更新日期：2011-02-10 00:00:00

abstract：:In man, two isoforms of growth hormone receptor (GHR) have been reported. The first, hGHR corresponds to the original form described by Leung et al. (J. Biol. Chem. 264 (1987) 9905-9910). The second, hGHRd3, missing 22 N-terminal amino acids is encoded by an mRNA derived from alternative splicing and deletion of the t...

journal_title：Molecular and cellular endocrinology

authors： Esposito N,Paterlini P,Kelly PA,Postel-Vinay MC,Finidori J

更新日期：1994-07-01 00:00:00

abstract：:Over the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which have accompanied the fin-to-limb transition, an evolutionary st...

journal_title：Molecular and cellular endocrinology

authors： Kondo T,Hérault Y,Zákány J,Duboule D

更新日期：1998-05-25 00:00:00

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study...

journal_title：Molecular and cellular endocrinology

authors： Kanczkowski W,Chatzigeorgiou A,Samus M,Tran N,Zacharowski K,Chavakis T,Bornstein SR

更新日期：2013-05-22 00:00:00

abstract：:TRESK (TWIK-related spinal cord K(+) channel, KCNK18) belongs to the two-pore domain (K2P) background (leak) potassium channel family. Unlike other K2P channels, TRESK is activated by the calcium signal in heterologous expression systems. The activation is mediated by the calcium/calmodulin-dependent protein phosphata...

journal_title：Molecular and cellular endocrinology

authors： Enyedi P,Braun G,Czirják G

更新日期：2012-04-28 00:00:00

abstract：:The Ca2+ dependency of the direct stimulatory effect of the gonadotropin-releasing hormone (GnRH) agonist analog [D-Ser(t-Bu)6]des-Gly10-GnRH-N-ethylamide (GnRHa) on progesterone production was investigated and compared to that of luteinizing hormone (LH) in rat granulosa cells from preovulatory follicles. Removal of ...

journal_title：Molecular and cellular endocrinology

authors： Eckstein N,Eshel A,Eli Y,Ayalon D,Naor Z

更新日期：1986-09-01 00:00:00

abstract：:It has already been shown that Wistar rat thyroid (WRT) cells in low concentrations of calf serum (0.5%) are under the influence of both thyrotropin (TSH) and insulin as regards growth. The present data show that epidermal growth factor (EGF), in concentrations up to 10 micrograms/ml, is not able to modify DNA synthes...

journal_title：Molecular and cellular endocrinology

authors： Rotella CM,Mavilia C,Frediani U,Toccafondi R

更新日期：1989-08-01 00:00:00

abstract：:Lipoprotein lipase (LPL) activity is known to be synthesized, active and functional in the 1-day-old rat liver: it peaks just at birth triggered by parturition. During suckling LPL mRNA, LPL synthesis and LPL activity are still high at 5 days and then fade reaching adult values at weaning. How LPL expression is gradua...

journal_title：Molecular and cellular endocrinology

authors： Julve J,Robert MQ,Llobera M,Peinado-Onsurbe J

更新日期：1996-01-15 00:00:00

abstract：:The Steroidogenic acute regulatory protein (StAR) directs mitochondrial cholesterol uptake through a C-terminal cholesterol binding domain (CBD) and a 62 amino acid N-terminal regulatory domain (NTD) that contains an import sequence and conserved sites for inner membrane metalloproteases. Deletion of the NTD prevents ...

journal_title：Molecular and cellular endocrinology

authors： Lee J,Yamazaki T,Dong H,Jefcoate C

更新日期：2017-02-05 00:00:00

abstract：:Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue ...

journal_title：Molecular and cellular endocrinology

authors： Lee P,Greenfield JR

更新日期：2015-12-15 00:00:00

abstract：:Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of An...

journal_title：Molecular and cellular endocrinology

authors： Gowrisankar YV,Clark MA

更新日期：2016-12-05 00:00:00

abstract：:The most widely conserved mammalian sperm antigen is sperm adhesion molecule 1, SPAM1/PH-20, which is also the major testicular hyaluronidase. This multifunctional glycosyl phosphatidylinositol (GPI)-linked protein plays several roles in fertilization and is encoded by a gene that resides among hyaluronidase family me...

journal_title：Molecular and cellular endocrinology

authors： Martin-DeLeon PA

更新日期：2006-05-16 00:00:00

abstract：:The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have...

journal_title：Molecular and cellular endocrinology

authors： Stocco DM,Clark BJ,Reinhart AJ,Williams SC,Dyson M,Dassi B,Walsh LP,Manna PR,Wang XJ,Zeleznik AJ,Orly J

更新日期：2001-05-25 00:00:00

abstract：:Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, PC2, CPE and preproNPY protein expression levels were compared among m...

journal_title：Molecular and cellular endocrinology

authors： Tang SS,Zhang JH,Liu HX,Li HZ

更新日期：2009-05-06 00:00:00

abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

journal_title：Molecular and cellular endocrinology

authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

更新日期：2018-02-05 00:00:00

abstract：:The antiestrogen tamoxifen has been successfully used to control estrogen receptor (ER) and progesterone receptor positive breast cancer. However, the development of antiestrogen resistance is frequently observed in patients following long term treatment. We have studied the development of antiestrogen resistance in v...

journal_title：Molecular and cellular endocrinology

authors： Jiang SY,Wolf DM,Yingling JM,Chang C,Jordan VC

更新日期：1992-12-01 00:00:00

abstract：:In recent years it has become evident that glucocorticoid receptor (GR) action in the nucleus is highly dynamic, characterized by a rapid exchange at the chromatin template. This stochastic mode of GR action couples perfectly with a deterministic pulsatile availability of endogenous ligand in vivo. The endogenous gluc...

journal_title：Molecular and cellular endocrinology

authors： Conway-Campbell BL,Pooley JR,Hager GL,Lightman SL

更新日期：2012-01-30 00:00:00

abstract：:Berberine has been shown to have insulin-sensitizing effect, but the molecular mechanism underlying remains elusive. In this work, we investigated the effect of berberine on insulin-induced signal transduction and glucose uptake in both insulin-sensitive and insulin-resistant rat skeletal muscle cells. Berberine incre...

journal_title：Molecular and cellular endocrinology

authors： Liu LZ,Cheung SC,Lan LL,Ho SK,Xu HX,Chan JC,Tong PC

更新日期：2010-04-12 00:00:00

abstract：:In amphibians, the main role of thyroid hormones (THs) is to regulate metamorphosis; however, there is evidence that THs also affect gonadal sexual differentiation. In this study, Silurana (Xenopus) tropicalis tadpoles were exposed to triiodothyronine (T3; 0, 0.5, 5 and 50 nM), the bioactive form of THs for 48h. Real-...

journal_title：Molecular and cellular endocrinology

authors： Duarte-Guterman P,Trudeau VL

更新日期：2011-01-01 00:00:00

abstract：:Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting...

journal_title：Molecular and cellular endocrinology

authors： Villa-Osaba A,Gahete MD,Cordoba-Chacon J,de Lecea L,Castaño JP,Luque RM

更新日期：2016-10-15 00:00:00

abstract：:It has recently been reported that phenol red, a pH indicator present in most tissue culture media, is a weak estrogen that can stimulate some estrogen-sensitive cells. However, the relative impact of phenol red on various cell lines is controversial. We examined the effect of phenol red on several estrogen-responsive...

journal_title：Molecular and cellular endocrinology

authors： Welshons WV,Wolf MF,Murphy CS,Jordan VC

更新日期：1988-06-01 00:00:00

abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

journal_title：Molecular and cellular endocrinology

authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

更新日期：2019-01-15 00:00:00

abstract：:It has been previously shown that corticotropin-releasing hormone (CRH) exerts antiproliferative activity on an estrogen-dependent tumor cell line, i.e. human endometrial adenocarcinoma Ishikawa (IK) cells. Here we have investigated the effects of CRH on another estrogen-dependent tumor cell line, human breast cancer ...

journal_title：Molecular and cellular endocrinology

authors： Graziani G,Tentori L,Muzi A,Vergati M,Tringali G,Pozzoli G,Navarra P

更新日期：2007-01-29 00:00:00

abstract：:Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated d-glucose that Akt1 and the post-translational modif...

journal_title：Molecular and cellular endocrinology

authors： Hou J,Chong ZZ,Shang YC,Maiese K

更新日期：2010-06-10 00:00:00

abstract：:The degradation products generated from A14 and B26 125I-labelled insulins in liver endosomes in vivo and in vitro have been isolated by high-performance liquid chromatography and cleavages in the B chain have been identified by automated radiosequence analysis. In rats sacrificed various times after injection of each...

journal_title：Molecular and cellular endocrinology

authors： Clot JP,Janicot M,Fouque F,Desbuquois B,Haumont PY,Lederer F

更新日期：1990-09-10 00:00:00

abstract：:Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA cod...

journal_title：Molecular and cellular endocrinology

authors： Baertschi AJ

更新日期：1994-05-01 00:00:00

abstract：:Hypothalamic dysfunction is a common feature of experimental obesity. Studies have identified at least three mechanisms involved in the development of hypothalamic neuronal defects in diet-induced obesity: i, inflammation; ii, endoplasmic reticulum stress; and iii, mitochondrial abnormalities. However, which of these ...

journal_title：Molecular and cellular endocrinology

authors： Carraro RS,Souza GF,Solon C,Razolli DS,Chausse B,Barbizan R,Victorio SC,Velloso LA

更新日期：2018-01-15 00:00:00

abstract：:The template for our understanding of the physiological role of the adrenal cortex was set by Hans Selye, who demonstrated its key involvement in the response to stress, of whatever origin, and who also introduced the terms glucocorticoid and mineralocorticoid. Despite this, from the late 1940s on there was certainly ...

journal_title：Molecular and cellular endocrinology

authors： Vinson GP

更新日期：2009-03-05 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00