Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells.

Abstract:

:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Foxp3 decreased cell proliferation and migration, but increased apoptosis, suggesting a positive role of Foxp3 in cancer growth. Interestingly, Foxp3 inhibition enhanced PPARγ expression and activity. In addition, Foxp3 inhibition downregulated NF-κB subunit p65 and cyclin D1 but upregulated caspase-3 levels. These molecular changes are in line with Foxp3 shRNA-mediated alteration of cell functions. Collectively, our study demonstrates that thyroid cancer cells express a high level of functional Foxp3 and that the inhibition of the Foxp3 suppresses the proliferation and migration but promotes apoptosis, suggesting that targeting Foxp3 in thyroid cancer cells may offer a novel therapeutic option for thyroid cancer.

journal_name

Mol Cell Endocrinol

authors

Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

doi

10.1016/j.mce.2014.10.006

subject

Has Abstract

pub_date

2015-01-05 00:00:00

pages

228-34

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00317-7

journal_volume

399

pub_type

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