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Epidermal growth factor inhibits thyrotropin-mediated synthesis of tissue-specific proteins in cultured ovine thyroid cells.

Abstract：

:Primary cultures of ovine thyroid cells were induced to differentiate by addition of thyrotropin (TSH). This was demonstrated as an accumulation of 2 thyroid-specific proteins, thyroglobulin and thyroid peroxidase, using immunofluorescent staining methods and immunoprecipitation of biosynthetically labeled cultures. As an additional measure of differentiation, cells exhibited a morphological response to TSH and regained the ability to incorporate radioactive iodide. Epidermal growth factor (EGF) markedly inhibited differentiation when added together with TSH. Thyroglobulin synthesis was reduced to low levels and peroxidase synthesis was reduced to levels that were undetectable by the methods used. Morphological changes in response to TSH were also diminished by EGF. The antagonistic interaction between TSH and EGF in regulating differentiation in cultured thyroid cells may reflect the type of control that exists in vivo.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Errick JE,Eggo MC,Burrow GN

doi

10.1016/0303-7207(85)90041-3

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

51-9

issue

1

eissn

0303-7207

issn

1872-8057

journal_volume

43

pub_type

杂志文章

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