Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: not all roads lead to Rome.

abstract：:While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

journal_title：Molecular and cellular endocrinology

authors： Thoennes SR,Tate PL,Price TM,Kilgore MW

更新日期：2000-02-25 00:00:00

abstract：:Hypothalamic dysfunction is a common feature of experimental obesity. Studies have identified at least three mechanisms involved in the development of hypothalamic neuronal defects in diet-induced obesity: i, inflammation; ii, endoplasmic reticulum stress; and iii, mitochondrial abnormalities. However, which of these ...

journal_title：Molecular and cellular endocrinology

authors： Carraro RS,Souza GF,Solon C,Razolli DS,Chausse B,Barbizan R,Victorio SC,Velloso LA

更新日期：2018-01-15 00:00:00

abstract：:Poly(A+)-containing mRNA from human term placenta was used to direct protein synthesis in a nuclease-treated rabbit reticulocyte lysate, which is dependent on mRNA and tRNA for maximal activity. The major protein product was human pre-placental lactogen (hPL). Addition of tRNA from rabbit liver, rabbit reticulocyte, h...

journal_title：Molecular and cellular endocrinology

authors： Kelly SJ,Loria J,Gyves MT,Ilan J

更新日期：1983-02-01 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:The oligosaccharide chains of pituitary glycoprotein hormones such as human thyroid-stimulating hormone (hTSH) have been shown to be important in biosynthesis, subunit association, secretion and bioactivity. However, the exact biological significance of these glycosylation variants (isoforms) remains controversial. Th...

journal_title：Molecular and cellular endocrinology

authors： Schaaf L,Leiprecht A,Saji M,Hübner U,Usadel KH,Kohn LD

更新日期：1997-09-19 00:00:00

abstract：:Growth hormone (GH) secretion, evoked by either pituitary adenylate cyclase-activating polypeptide (PACAP) or dopamine (DA), is dependent on both voltage-sensitive calcium channels (VSCC) and cAMP signaling in goldfish. We further characterized the involvement of Ca2+ in evoked release by PACAP and DA, by examining th...

journal_title：Molecular and cellular endocrinology

authors： Chang JP,Wong CJ,Davis PJ,Soetaert B,Fedorow C,Sawisky G

更新日期：2003-08-29 00:00:00

abstract：:Peripheral benzodiazepine (BZ) binding sites (PBzS) were characterized on placental explant membranes. [3H]PK 11195, an isoquinoline carboxamide derivative, which is a ligand specific for PBzS, labeled these sites with an equilibrium dissociation constant of 2.1 nM; the maximal number of binding sites was 396 fmol/mg ...

journal_title：Molecular and cellular endocrinology

authors： Barnea ER,Fares F,Gavish M

更新日期：1989-07-01 00:00:00

abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

journal_title：Molecular and cellular endocrinology

authors： Thompson BR,Lobo S,Bernlohr DA

更新日期：2010-04-29 00:00:00

abstract：:Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to hypoxia. We found that hypobaric hypoxia at a simulated altitude of 5000 m significantly reduced the body wei...

journal_title：Molecular and cellular endocrinology

authors： Xiong Y,Qu Z,Chen N,Gong H,Song M,Chen X,Du J,Xu C

更新日期：2014-07-05 00:00:00

abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

journal_title：Molecular and cellular endocrinology

authors： Kurosu H,Kuro-O M

更新日期：2009-02-05 00:00:00

abstract：:Little is known about the regulation and cellular distribution of androgen receptors (ARs) in female rodent brains at various stages of the oestrous cycle. This information is critical for further studies of androgen signalling in the regulation of brain function under physiological and pathophysiological conditions. ...

journal_title：Molecular and cellular endocrinology

authors： Feng Y,Weijdegård B,Wang T,Egecioglu E,Fernandez-Rodriguez J,Huhtaniemi I,Stener-Victorin E,Billig H,Shao R

更新日期：2010-06-10 00:00:00

abstract：:The ovulatory process is characterized by tissue wounding and, after oocyte expulsion, by healing being connected to the formation of a corpus luteum (CL). The ovulatory event thus compares with a sterile inflammation. The concept is forwarded that the ovulatory process depends on innate immunity (INIM) function. The ...

journal_title：Molecular and cellular endocrinology

authors： Spanel-Borowski K

更新日期：2011-02-10 00:00:00

abstract：:Rat thyroid tissue and cultured rat thyrocyte lines contain two thyroglobulin (Tg) mRNAs: a 9 kb rTg-1 mRNA encoding the 330, kDa Tg monomer and a recently described 0.95 kb rTg-2 mRNA. These transcripts have identical 5' coding sequences (641 nucleotides); however, the 3' end of rTg-2 is comprised of coding and non-c...

journal_title：Molecular and cellular endocrinology

authors： Graves PN,Davies TF

更新日期：1993-06-01 00:00:00

abstract：:Adipose tissue-derived adipokines play important roles as regulators of skeletal growth and development. CTRP1, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. It is expressed at high levels in adipose tissue and has recently emerged as a novel adipo...

journal_title：Molecular and cellular endocrinology

authors： Akiyama H,Otani M,Sato S,Toyosawa S,Furukawa S,Wakisaka S,Maeda T

更新日期：2013-04-30 00:00:00

abstract：:Cultured human luteinized granulosa cells (GC) are a unique model to study regulation of the human corpus luteum, e.g. by local factors, including acetylcholine (ACh). GC express functional ACh-receptors of the M1-type (M1R). Priming with the cholinergic agonist carbachol for 24 h, followed by a 24 h stimulation with ...

journal_title：Molecular and cellular endocrinology

authors： Fritz S,Grünert R,Stocco DM,Hales DB,Mayerhofer A

更新日期：2001-01-22 00:00:00

abstract：:Human estrogen receptor alpha (ER) mRNA is a mixture of wild type and alternatively spliced variants. Many studies have examined the potential of ER mRNA profiles to serve as diagnostic/prognostic cancer biomarkers, but only a few have attempted to correlate ER mRNA profiles with protein expression. Representative ER ...

journal_title：Molecular and cellular endocrinology

authors： Fasco MJ,Keyomarsi K,Arcaro KF,Gierthy JF

更新日期：2000-04-25 00:00:00

abstract：:Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role d...

journal_title：Molecular and cellular endocrinology

authors： Zhang XH,Liang X,Wang TS,Liang XH,Zuo RJ,Deng WB,Zhang ZR,Qin FN,Zhao ZA,Yang ZM

更新日期：2013-12-05 00:00:00

abstract：:We examined the effects of growth hormone (GH), prolactin (PRL) and insulin-like growth factor-I (IGF-I) on DNA synthesis, and insulin-like growth factor binding protein 3 (IGFBP-3) gene expression, in a rat beta-cell line INS-1. GH and PRL were equally effective in increasing DNA synthesis and IGFBP-3 gene expression...

journal_title：Molecular and cellular endocrinology

authors： De W,Bréant B,Czernichow P,Asfari M

更新日期：1995-10-30 00:00:00

abstract：:The distribution of the steroidogenic acute regulatory protein (StAR) inside thecal and granulosa-lutein cells of human corpus luteum (CL) was assessed by immunoelectron microscopy. We found greater levels of StAR immunolabeling in steroidogenic cells from early- and mid-than in late luteal phase CL and lower levels i...

journal_title：Molecular and cellular endocrinology

authors： Sierralta WD,Kohen P,Castro O,Muñoz A,Strauss JF 3rd,Devoto L

更新日期：2005-10-20 00:00:00

abstract：:Melanocortin 4 receptors (MC4R) are mainly expressed in the brain. We previously showed that the anti-inflammatory action of α-melanocyte-stimulating hormone (α-MSH) in rat hypothalamus and in cultured astrocytes involved MC4R activation. However, MC4R mechanisms of action remain undetermined. Since brain-derived neur...

journal_title：Molecular and cellular endocrinology

authors： Caruso C,Carniglia L,Durand D,Gonzalez PV,Scimonelli TN,Lasaga M

更新日期：2012-01-02 00:00:00

abstract：:The concentration of high-affinity estradiol binding sites in the uteri and pituitaries of normal and two dwarf strains of mice was studied. The two dwarf strains are characterized by their total absence of growth hormone or prolactin synthesis and low or absent TSH production. The uteri of the dwarf mice are small bu...

journal_title：Molecular and cellular endocrinology

authors： Sartor P,Slabaugh M,Sakai D,Gorski J

更新日期：1983-01-01 00:00:00

abstract：:The extracellular matrix (ECM) component hyaluronan (HA) is considered to contribute to the optimal development of the gametes and the embryo. In this study, the regulation and localization of HA, its synthases (HAS 1-3) and the receptors CD44, RHAMM, and putative HARE were investigated in bovine oviducts during the e...

journal_title：Molecular and cellular endocrinology

authors： Ulbrich SE,Schoenfelder M,Thoene S,Einspanier R

更新日期：2004-02-12 00:00:00

abstract：:Steroidogenic activity in the mature corpus luteum of most mammals depends upon provision of cholesterol from the circulating lipoproteins. In cattle, as in many species, high-density lipoprotein (HDL) is the major lipoprotein involved. The recent identification of the scavenger receptor SR-BI as an HDL-receptor allow...

journal_title：Molecular and cellular endocrinology

authors： Rajapaksha WR,McBride M,Robertson L,O'Shaughnessy PJ

更新日期：1997-10-31 00:00:00

abstract：:The CYP11A1 gene encodes cytochrome P450scc, the enzyme catalyzing the first step of steroid biosynthesis in the adrenal and gonad. We generated transgenic mice containing 2.3 kb of the 5'-flanking region of CYP11A1 driving LacZ reporter gene expression, in order to study hormonal control of CYP11A1 gene expression in...

journal_title：Molecular and cellular endocrinology

authors： Huang Y,Hu M,Hsu N,Wang CL,Chung B

更新日期：2001-04-25 00:00:00

abstract：:The aim of this study was to examine the first step in steroidogenesis in male and female gonads of fetal rats. Pregnenolone production was measured by radioimmunoassay in organ culture, conversion of [3H]cholesterol to [3H]pregnenolone was evaluated in isolated mitochondria and cytochrome P-450scc was revealed by imm...

journal_title：Molecular and cellular endocrinology

authors： Rouiller V,Gangnerau MN,Vayssiere JL,Picon R

更新日期：1990-08-20 00:00:00

abstract：:Eating disorders, namely anorexia nervosa, bulimia nervosa and binge eating disorder are frequent diseases and often complicated by comorbidities, e.g. psychiatric or cardiovascular comorbidities. It is to note that also gastrointestinal symptoms/complications are frequently observed in patients with eating disorders....

journal_title：Molecular and cellular endocrinology

authors： Hetterich L,Mack I,Giel KE,Zipfel S,Stengel A

更新日期：2019-11-01 00:00:00

abstract：:Differentiation of human placental mononuclear trophoblasts into a multinucleate syncytium involves up-regulation of key proteins promoting cell fusion and increased capacity for placental hormonogenesis. It is well established that the activation of adenylyl cyclase leads to increased expression of trophoblast fusoge...

journal_title：Molecular and cellular endocrinology

authors： Delidaki M,Gu M,Hein A,Vatish M,Grammatopoulos DK

更新日期：2011-01-30 00:00:00

abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

journal_title：Molecular and cellular endocrinology

authors： Scammell JG,Wear LB,Von Haven R

更新日期：1990-06-18 00:00:00

abstract：:The aims of the study were to characterize leptin and it is receptor (LEPR) proteins immunoexpression in ovine ovaries and to evaluate the effects of leptin on development of secondary follicles cultured in vitro. The ovaries were collected and fixed for immunohistochemical analysis. Additional pairs of ovaries were c...

journal_title：Molecular and cellular endocrinology

authors： Macedo TJS,Santos JMS,Bezerra MÉS,Menezes VG,Gouveia BB,Barbosa LMR,Lins TLBG,Monte APO,Barberino RS,Batista AM,Barros VRP,Wischral A,Queiroz MAA,Araújo GGL,Matos MHT

更新日期：2019-09-15 00:00:00

abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

journal_title：Molecular and cellular endocrinology

authors： Wyrwoll CS,Mark PJ,Waddell BJ

更新日期：2005-09-28 00:00:00