Growth hormone (GH) and prolactin (PRL) regulate IGFBP-3 gene expression in rat beta-cells.

abstract：:The oligosaccharide chains of pituitary glycoprotein hormones such as human thyroid-stimulating hormone (hTSH) have been shown to be important in biosynthesis, subunit association, secretion and bioactivity. However, the exact biological significance of these glycosylation variants (isoforms) remains controversial. Th...

journal_title：Molecular and cellular endocrinology

authors： Schaaf L,Leiprecht A,Saji M,Hübner U,Usadel KH,Kohn LD

更新日期：1997-09-19 00:00:00

abstract：:The identification of estrogen-responsive genes in the heart, is necessary to understand estrogen-induced changes in cardiac function. Using Delta RNA fingerprinting, we demonstrate that a single injection of estradiol benzoate (50 microg, s.c.) revealed mRNA species that were elevated, down-regulated, or were unaffec...

journal_title：Molecular and cellular endocrinology

authors： Too CK,Giles A,Wilkinson M

更新日期：1999-04-25 00:00:00

abstract：:Osteogenic activities of activin, a member of TGF-beta superfamily, have been shown in both in vivo and in vitro studies. Local injection of activin promoted fracture healing in rat fibula fracture models. Since both activin and its receptor are expressed during fracture healing, activin would be involved in the heali...

journal_title：Molecular and cellular endocrinology

authors： Sakai R,Eto Y

更新日期：2001-06-30 00:00:00

abstract：:Glucose uptake by brown adipose tissue, measured following deoxyglucose injection in vivo, was increased by 6- and 11-fold following 2 and 14 days of cold exposure, respectively. To look for the possible mechanism of these modifications, the glucose transporter Glut 4 has been characterized at the protein and mRNA lev...

journal_title：Molecular and cellular endocrinology

authors： Olichon-Berthe C,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1992-11-01 00:00:00

abstract：:Characteristics of the alpha-adrenergic stimulation of ACTH, beta-endorphin + beta-LPH and alpha-MSH release were studied in rat anterior pituitary cells in primary culture. Parallel changes of ACTH, beta-endorphin + beta-LPH and alpha-MSh release were found under all stimulatory and inhibitory conditions by natural a...

journal_title：Molecular and cellular endocrinology

authors： Raymond V,Lépine J,Giguère V,Lissitzky JC,Côté J,Labrie F

更新日期：1981-06-01 00:00:00

abstract：:A quantitative assay using a reverse transcriptase-linked polymerase chain reaction has been developed for measuring the levels of rANP and iso-rANP mRNA. A linear correlation between total RNA template and amplified cDNA was obtained for the amplification of cDNA from both iso-rANP and rANP mRNAs even when both cDNAs...

journal_title：Molecular and cellular endocrinology

authors： Roy RN,Pang SC,Flynn TG

更新日期：1992-07-01 00:00:00

abstract：:Fsh-mediated regulation of zebrafish spermatogenesis includes modulating the expression of testicular growth factors. Here, we study if and how two Sertoli cell-derived Fsh-responsive growth factors, anti-Müllerian hormone (Amh; inhibiting steroidogenesis and germ cell differentiation) and insulin-like growth factor 3...

journal_title：Molecular and cellular endocrinology

authors： Morais RDVS,Crespo D,Nóbrega RH,Lemos MS,van de Kant HJG,de França LR,Male R,Bogerd J,Schulz RW

更新日期：2017-10-15 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to pigmentation to the regulation of feeding. One approach to unraveling the complexi...

journal_title：Molecular and cellular endocrinology

authors： Costa JL,Forbes S,Brennan MB,Hochgeschwender U

更新日期：2011-04-10 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is the common precursor of several pituitary hormones including alpha-melanotropic hormone, adrenocorticotropic hormone, beta-lipotropin and beta-endorphin. The porcine POMC cDNA was inserted downstream from the late promoter of an SV40-derived expression vector and co-transfected in NIH 3T...

journal_title：Molecular and cellular endocrinology

authors： Zollinger L,Noël G,Des Parois L,Sales V,Crine P,Boileau G

更新日期：1988-07-01 00:00:00

abstract：:After i.m. injection of [3H]butyrobetaine into rats, the accumulation of carnitine into the epididymis, prostate gland, seminal vesicles, testis and heart was studied. The concentration of radiolabeled carnitine into the cauda epididymis increased linearly with time up to 72 h after the injection of the precursor, whi...

journal_title：Molecular and cellular endocrinology

authors： Bohmer T,Hansson V

更新日期：1975-08-01 00:00:00

abstract：:Prostaglandin A1 (PGA1) increases heat shock element (HSE)-mediated transcription, thereby enhancing expression of HSE-bearing genes, including heat shock proteins. Because we recently found functional HSEs in the human and rodent c-fos promoters, we hypothesized that PGA1 might increase c-fos expression through the H...

journal_title：Molecular and cellular endocrinology

authors： Ishikawa T,Sekine N,Hata K,Igarashi T,Fujita T

更新日期：2000-06-01 00:00:00

abstract：:Ghrelin is the only known circulating hormone that acts on peripheral and central targets to increase food intake and promote adiposity. The present review focuses on the possible clinical relevance of ghrelin in the regulation of human feeding behavior in individuals with obesity and other eating disorders such as Pr...

journal_title：Molecular and cellular endocrinology

authors： Yi CX,Heppner K,Tschöp MH

更新日期：2011-06-20 00:00:00

abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

journal_title：Molecular and cellular endocrinology

authors： Podesta EJ,Dufau ML,Catt KJ

更新日期：1976-06-01 00:00:00

abstract：:In mammalian cells, the insulin receptor substrate 1 protein (IRS-1) is a specific substrate for insulin and IGF-1 receptor tyrosine kinases which is involved in mediating metabolic and mitogenic actions of insulin and IGFs. In order to determine if IRS-1 is also essential in a chicken derived hepatoma cell line (LMH ...

journal_title：Molecular and cellular endocrinology

authors： Taouis M,Dupont J,Gillet A,Derouet M,Simon J

更新日期：1998-02-01 00:00:00

abstract：:Thyroid hormones participate in the regulation of growth, development and energy expenditure of vertebrates. Type I (D1) and type II 5'deiodinases catalyze the peripheral conversion of the thyroid prohormone thyroxine to the active form triiodothyronine (T3). D1 is expressed in organs like liver, thyroid, and lactatin...

journal_title：Molecular and cellular endocrinology

authors： García-Solís P,Aceves C

更新日期：2003-03-28 00:00:00

abstract：:Very few silver grains were seen on the luteal cell surface and none intracellularly after incubation for 2 h at 4 degrees C with 10 nM [3H]prostaglandin (PG) E1 or [3H]PGF2 alpha. However, incubation at 22 degrees C or 38 degrees C for 2 h resulted in association of numerous grains on the luteal cell surface as well ...

journal_title：Molecular and cellular endocrinology

authors： Chegini N,Rao CV,Cobbs G

更新日期：1984-12-01 00:00:00

abstract：:When measured in vitro using human placental microsomal preparations, the aromatization of 16alpha-hydroxytestosterone to estriol and androstenedione to estrone and estradiol proceeds at almost identical initial rates. Important differences between 16alpha-hydroxytestosterone and adrostenedione aromatization are evide...

journal_title：Molecular and cellular endocrinology

authors： Canick JA,Ryan KJ

更新日期：1976-12-01 00:00:00

abstract：:Detailed imaging of the pituitary gland is a prerequisite for a successful outcome of transsphenoidal hypophysectomy in dogs because it allows for accurate preoperative localization and assessment of the size of the pituitary gland. Cisternography allows assessment of even small increases in the height of the pituitar...

journal_title：Molecular and cellular endocrinology

authors： van der Vlugt-Meijer RH,Voorhout G,Meij BP

更新日期：2002-11-29 00:00:00

abstract：:Calcium is a second messenger responsible for regulating a wide range of cellular processes. It is normally presented as brief spikes even in non-excitable cells. The necessity of limiting the period of calcium stimulation to brief bursts may depend upon the fact that prolonged elevation of calcium can be toxic. It ca...

journal_title：Molecular and cellular endocrinology

authors： Berridge MJ

更新日期：1994-01-01 00:00:00

abstract：:Advanced glycation end products (AGEs), formed at an accelerated rate under diabetes, play a role in inflammation and fibrosis in mesangial areas in diabetic nephropathy (DN). However, the transcriptional modulator that mediates the cellular response to AGEs remains largely obscure. Our goal was to determine whether m...

journal_title：Molecular and cellular endocrinology

authors： Chen Q,Huang J,Gong W,Chen Z,Huang J,Liu P,Huang H

更新日期：2018-01-15 00:00:00

abstract：:Cardiovascular effects of parathyroid hormone (PTH) have been recently described. Pharmacological doses of PTH both reduce arterial pressure and increase blood flow of vascular beds. Two possible cellular mechanisms were investigated: (a) transmembrane Ca2+ fluxes and (b) cyclic AMP response in vascular smooth muscle....

journal_title：Molecular and cellular endocrinology

authors： Schleiffer R,Bergmann C,Pernot F,Gairard A

更新日期：1989-11-01 00:00:00

abstract：:Total RNA from several adult (6-18-month-old) rabbit tissues was characterized using an oligonucleotide probe derived from the extracellular domain of the nucleotide sequence of the rabbit growth hormone receptor (GH-R) cDNA. Multiple GH-R mRNA species of approximately 4.6, approximately 3.3, 2.1 and approximately 1.4...

journal_title：Molecular and cellular endocrinology

authors： Ymer SI,Herington AC

更新日期：1992-01-01 00:00:00

abstract：:In cultured human lymphocytes (IM-9) and in isolated rat adipocytes human growth hormone is substrate for a receptor-mediated degradation. When the cells are incubated with monoiodinated human growth hormone half of the radioactivity dissociating from the cells is in the form of [125I]monoiodotyrosine. Since IM-9 lymp...

journal_title：Molecular and cellular endocrinology

authors： Weyer B,Sonne O

更新日期：1985-06-01 00:00:00

abstract：:The heterodimeric 'pregnancy-specific' hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the beta-chain expressed in the absence of alpha-chain, is aberrantly expressed in a number of different tumors ...

journal_title：Molecular and cellular endocrinology

authors： Delves PJ,Iles RK,Roitt IM,Lund T

更新日期：2007-01-02 00:00:00

abstract：:Bone marrow-derived leukocytes are present in human endometrium/decidua and are believed to serve a variety of functions in this tissue. The number and type of leukocytes in endometrium/decidua vary with the hormonal milieu of the ovarian cycle, with blastocyst implantation, and during pregnancy. The factors that regu...

journal_title：Molecular and cellular endocrinology

authors： Arici A,MacDonald PC,Casey ML

更新日期：1995-02-01 00:00:00

abstract：:The peculiarities of cellular and tissue distribution of prolactin receptors (PRLR) in the liver of female and male rats with different sex steroid status were investigated in paraplast-embedded tissue with the indirect immunoperoxidase technique. Two clones of antibodies directed outside the PRL-binding site (U6) or ...

journal_title：Molecular and cellular endocrinology

authors： Smirnova OV,Petraschuk OM,Kelly PA

更新日期：1994-10-01 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells. Plasma SHBG is secreted by the liver under the control of hormones and nutritional factors. In the human hepatoma cell line (HepG2), thyroid and estrogenic hor...

journal_title：Molecular and cellular endocrinology

authors： Pugeat M,Nader N,Hogeveen K,Raverot G,Déchaud H,Grenot C

更新日期：2010-03-05 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00

abstract：:Mammalian α4 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase. This study showed induction of the EDD protein by progesterone, 17β-estradiol and prolactin in breast cancer cells....

journal_title：Molecular and cellular endocrinology

authors： McDonald WJ,Thomas LN,Koirala S,Too CKL

更新日期：2014-01-25 00:00:00

abstract：:Aldosterone plays an important role in electrolyte and blood pressure homeostasis. Our studies have focused on the role of aldosterone in essential hypertension. We have shown that plasma aldosterone and ARR are heritable characteristics and that aldosterone concentrations in older subjects are inversely correlated wi...

journal_title：Molecular and cellular endocrinology

authors： Davies E,Mackenzie SM,Freel EM,Alvarez-Madrazo S,Fraser R,Connell JM

更新日期：2009-03-05 00:00:00